Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis

Autor: Stefan Schefczyk, Xufeng Luo, Yaojie Liang, Mike Hasenberg, Bernd Walkenfort, Martin Trippler, Jonas Schuhenn, Kathrin Sutter, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)

Abstract Hepatitis B virus (HBV)-transgenic mice exhibit competent innate immunity and are therefore an ideal model for considering intrinsic or cell-based mechanisms in HBV pathophysiology. A highly replicative model that has been little used, let a

Externí odkaz: https://doaj.org/article/d8033cbdd44a4c2e8375ba24f2d4d013

SRSF1 acts as an IFN-I-regulated cellular dependency factor decisively affecting HIV-1 post-integration steps

Autor: Helene Sertznig, Fabian Roesmann, Alexander Wilhelm, Delia Heininger, Barbara Bleekmann, Carina Elsner, Mario Santiago, Jonas Schuhenn, Zehra Karakoese, Yvonne Benatzy, Ryan Snodgrass, Stefan Esser, Kathrin Sutter, Ulf Dittmer, Marek Widera

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Efficient HIV-1 replication depends on balanced levels of host cell components including cellular splicing factors as the family of serine/arginine-rich splicing factors (SRSF, 1–10). Type I interferons (IFN-I) play a crucial role in the innate imm

Externí odkaz: https://doaj.org/article/7a4ac982719d42a183ae0f8d9778d433

A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function

Autor: Toni Luise Meister, Yannick Brüggemann, Maximilian K. Nocke, Rainer G. Ulrich, Jonas Schuhenn, Kathrin Sutter, André Gömer, Verian Bader, Konstanze F. Winklhofer, Ruth Broering, Lieven Verhoye, Philip Meuleman, Florian W. R. Vondran, Charline Camuzet, Laurence Cocquerel, Daniel Todt, Eike Steinmann

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, ⟨10.1073/pnas.2202653119⟩

International audience; Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically transmitted viral hepatitis worldwide. Ribavirin (RBV) is currently the only treatment option for many patients; h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd075dd8023b99f1b3d7c63845e7185
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85135978610

IFNα subtype-specific susceptibility of HBV in the course of chronic infection

Autor: Xiaohong, Xie, Zehra, Karakoese, Dilhumare, Ablikim, Julia, Ickler, Jonas, Schuhenn, Xiaoqing, Zeng, Xuemei, Feng, Xuecheng, Yang, Ulf, Dittmer, Dongliang, Yang, Kathrin, Sutter, Jia, Liu

Chronic hepatitis B virus (HBV) infection continues to be a major health problem worldwide and remains hard to be cured. Therapy with interferon (IFN) α is an important method for the clinical treatment of chronic hepatitis B. IFNα exhibits direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0ecd2b5ff788d943f8a756556137bd
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85140830491

Research on Hepatitis B Virus Published by Researchers at University of Duisburg-Essen (Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis).

Publikováno v: Hepatitis Weekly; 1/9/2024, p371-371, 1p