Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jonah Simon"'
Autor:
Saba N. Baskoylu, Natalie Chapkis, Burak Unsal, Jeremy Lins, Kelsey Schuch, Jonah Simon, Anne C. Hart
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110195- (2022)
Summary: How mutations in FUS lead to neuronal dysfunction in amyotrophic lateral sclerosis (ALS) patients remains unclear. To examine mechanisms underlying ALS FUS dysfunction, we generate C. elegans knockin models using CRISPR-Cas9-mediated genome
Externí odkaz:
https://doaj.org/article/94f38500ab4a4a61b1e66a254d5470e8
Autor:
Saba N Baskoylu, Jill Yersak, Patrick O'Hern, Sarah Grosser, Jonah Simon, Sarah Kim, Kelsey Schuch, Maria Dimitriadi, Katherine S Yanagi, Jeremy Lins, Anne C Hart
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007682 (2018)
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 overexpression models suppo
Externí odkaz:
https://doaj.org/article/c98b330853fd493998c3ad5ea316c352
Autor:
Patrick J O'Hern, Inês do Carmo G. Gonçalves, Johanna Brecht, Eduardo Javier López Soto, Jonah Simon, Natalie Chapkis, Diane Lipscombe, Min Jeong Kye, Anne C Hart
Publikováno v:
eLife, Vol 6 (2017)
Spinal Muscular Atrophy (SMA) is caused by diminished Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and spinal motor neuron (MN) loss. Here, we report that reduced SMN function impacts the action of a per
Externí odkaz:
https://doaj.org/article/fdd6095295904033b37f7e73f69d3f46
Autor:
Zachary Finkel, Fatima Esteban, Brianna Rodriguez, Tanner Clifford, Adelina Joseph, Hani Alostaz, Mridul Dalmia, Juan Gutierrez, Matthew J. Tamasi, Samuel Ming Zhang, Jonah Simone, Hafize Petekci, Susmita Nath, Miriam Escott, Shivam Kumar Garg, Adam J. Gormley, Suneel Kumar, Sonia Gulati, Li Cai
Publikováno v:
Neurotherapeutics, Vol 21, Iss 4, Pp e00362- (2024)
Genomic screened homeobox 1 (Gsx1 or Gsh1) is a neurogenic transcription factor required for the generation of excitatory and inhibitory interneurons during spinal cord development. In the adult, lentivirus (LV) mediated Gsx1 expression promotes neur
Externí odkaz:
https://doaj.org/article/f01b4eae704842cea72b577e97bd7cfd
Autor:
Meizhong Jin, Linlong Xue, Sharon A. Townson, Alan C. Rigby, Siminia Grigoriu, Kathryn M. Luly, Earl W. May, Alex Yuzhakov, Cindy C. Benod, Michelle L. Stewart, Alan S. Mann, Mark J. Mulvihill, Anna Kohlmann, Nicholas Perl, Jason T. Lowe, Jonah Simon, Alec D Silver, Gregory L. Verdine, Roy M. Pollock, Minyun Zhou, Seung-Joo Lee
Publikováno v:
Molecular Cancer Research. 18:B37-B37
Activating mutations in RAS proteins occur in ~1/3 of human cancers. These mutations impair the ability of the protein to hydrolyze GTP to GDP. As a result, mutant RAS proteins exist predominantly in the GTP-bound state, which directly activates aber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::706bd742386bb94e9909138f07069c19
https://doi.org/10.1158/1557-3125.ras18-b37
https://doi.org/10.1158/1557-3125.ras18-b37
Autor:
Inês do Carmo G. Gonçalves, Min Jeong Kye, Eduardo Javier López Soto, Anne C. Hart, Johanna Brecht, Patrick J O'Hern, Natalie Chapkis, Diane Lipscombe, Jonah Simon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d37292d82b8a22b9f29f49ed85fb294
https://doi.org/10.7554/elife.20752.038
https://doi.org/10.7554/elife.20752.038
Autor:
Jonah Simon, Min Jeong Kye, Inês do Carmo G. Gonçalves, Patrick J O'Hern, Natalie Chapkis, Eduardo Javier López Soto, Diane Lipscombe, Johanna Brecht, Anne C. Hart
Publikováno v:
eLife
eLife, Vol 6 (2017)
eLife, Vol 6 (2017)
Spinal Muscular Atrophy (SMA) is caused by diminished Survival of Motor Neuron (SMN) protein, leading to neuromuscular junction (NMJ) dysfunction and spinal motor neuron (MN) loss. Here, we report that reduced SMN function impacts the action of a per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762df1a53ac4b6de205c4bc238ff695f
https://pubmed.ncbi.nlm.nih.gov/28463115
https://pubmed.ncbi.nlm.nih.gov/28463115
Autor:
Jill M. Yersak, Patrick J O'Hern, Anne C. Hart, Maria Dimitriadi, Sarah Grosser, Kelsey N. Schuch, Saba N. Baskoylu, Sarah Kim, Katherine S. Yanagi, Jonah Simon, Jeremy Lins
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 14, Iss 10, p e1007682 (2018)
PLoS Genetics, Vol 14, Iss 10, p e1007682 (2018)
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 overexpression models suppo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e364bdcf748ceea4a4365eacb7ce5a68
https://doi.org/10.1371/journal.pgen.1007682
https://doi.org/10.1371/journal.pgen.1007682