Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Jonah R Chan"'
Autor:
Kae-Jiun Chang, Ira Agrawal, Anna Vainshtein, Wan Yun Ho, Wendy Xin, Greg Tucker-Kellogg, Keiichiro Susuki, Elior Peles, Shuo-Chien Ling, Jonah R Chan
Publikováno v:
eLife, Vol 10 (2021)
TDP-43 is extensively studied in neurons in physiological and pathological contexts. However, emerging evidence indicates that glial cells are also reliant on TDP-43 function. We demonstrate that deletion of TDP-43 in Schwann cells results in a drama
Externí odkaz:
https://doaj.org/article/806e78a46128409587bd9290f6d060f7
Publikováno v:
eLife, Vol 10 (2021)
The inflammatory environment of demyelinated lesions in multiple sclerosis (MS) patients contributes to remyelination failure. Inflammation activates a cytoprotective pathway, the integrated stress response (ISR), but it remains unclear whether enhan
Externí odkaz:
https://doaj.org/article/7596443639964ebc8b31fcd2d7283054
Autor:
Feng Mei, Klaus Lehmann-Horn, Yun-An A Shen, Kelsey A Rankin, Karin J Stebbins, Daniel S Lorrain, Kara Pekarek, Sharon A Sagan, Lan Xiao, Cory Teuscher, H-Christian von Büdingen, Jürgen Wess, J Josh Lawrence, Ari J Green, Stephen PJ Fancy, Scott S Zamvil, Jonah R Chan
Publikováno v:
eLife, Vol 5 (2016)
Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While remyelination promises to restore lost function, it remains unclear whether remyelination will prevent axonal loss. Inflammatory demyelination is accompanied by si
Externí odkaz:
https://doaj.org/article/4da806c40b4949a2851d1bc03be524f7
Autor:
Breanne L. Harty, Fernanda Coelho, Sarah E. Pease-Raissi, Amit Mogha, Sarah D. Ackerman, Amy L. Herbert, Robert W. Gereau, Judith P. Golden, David A. Lyons, Jonah R. Chan, Kelly R. Monk
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The authors find that deletion from Schwann cells of an E3 ubiquitin ligase component called Fbxw7 leads to a phenotype reminiscent of myelination in the central nervous system where a single oligodendrocyte ensheaths multiple axons.
Externí odkaz:
https://doaj.org/article/17c998c1a86747189f3f8c1962a53a63
Autor:
Yanan Chen, Songhua Quan, Vaibhav Patil, Rejani B. Kunjamma, Haley M. Tokars, Eric D. Leisten, Godwin Joy, Samantha Wills, Jonah R. Chan, Yvette C. Wong, Brian Popko
Publikováno v:
Glia.
Autor:
Eduardo Caverzasi, Nico Papinutto, Christian Cordano, Gina Kirkish, Tristan J. Gundel, Alyssa Zhu, Amit Vijay Akula, W. John Boscardin, Heiko Neeb, Roland G. Henry, Jonah R. Chan, Ari J. Green
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 20
Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS). Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and imaging biomarkers are required to measure and corroborate myelin res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fbfaccd4c88198588eabbd4544e231
https://escholarship.org/uc/item/9p6325dc
https://escholarship.org/uc/item/9p6325dc
Autor:
Christian Cordano, Jung H Sin, Garrett Timmons, Hao H Yiu, Karin Stebbins, Caroline Guglielmetti, Andres Cruz-Herranz, Wendy Xin, Daniel Lorrain, Jonah R Chan, Ari J Green
Publikováno v:
Brain : a journal of neurology, vol 145, iss 11
Brain
Brain
Many biomarkers in clinical neuroscience lack pathological certification. This issue is potentially a significant contributor to the limited success of neuroprotective and neurorestorative therapies for human neurological disease—and is evident eve
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 544-550.e3 (2018)
Summary: Emerging evidence suggests that neuronal signaling is important for oligodendrocyte myelination; however, the necessity of this signaling during development is unclear. By eliminating dynamic neuronal signaling along the developing optic ner
Externí odkaz:
https://doaj.org/article/ec720413336e43cb82181c0a126042fd
Autor:
Sung Ok Yoon, Chhavy Tep, Vivianne E. Morrison, Jonah R. Chan, Thiago C. Genaro-Mattos, Bruce D. Carter, Mi Lyang Kim, Ned A. Porter, Jae Cheon Ryu, Rose M. Follis
Publikováno v:
J Neurosci
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 42
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol 41, iss 42
We report that the neurotrophin receptor p75 contributes to sensory neuron survival through the regulation of cholesterol metabolism in Schwann cells. Selective deletion of p75 in mouse Schwann cells of either sex resulted in a 30% loss of dorsal roo
Autor:
Wendy, Xin, Jonah R, Chan
Publikováno v:
Nature neuroscience. 25(10)