Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, iC3b, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis

Autor: Eleftheria Kodosaki, Colm Healy, Jonah F. Byrne, Melanie Föcking, Mary Cannon, Diana O. Perkins, David Cotter, Meike Heurich

Publikováno v: Biomarkers in Neuropsychiatry, Vol 10, Iss , Pp 100097- (2024)

The complement system is an important part of the innate immune system and plays a key role in inflammatory processes. Concentrations of complement activation fragments in plasma are markers of systemic activation and have been found to be altered in

Externí odkaz: https://doaj.org/article/a007b24e7a66473eba225d625d9bf8e7

Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis

Autor: Subash Raj Susai, Colm Healy, David Mongan, Meike Heurich, Jonah F. Byrne, Mary Cannon, Gerard Cagney, Kieran Wynne, Connie Markulev, Miriam R. Schäfer, Maximus Berger, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Rebekah Street, Andrew Thompson, Alison Ruth Yung, Barnaby Nelson, Patrick D. McGorry, Melanie Föcking, G. Paul Amminger, David Cotter

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates the molecular mechanism of omega-3 PUFA-associated therapeutic effects in clinical high-risk

Externí odkaz: https://doaj.org/article/ef015f3560c34a10bba31b92235544a1

Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood: A nested case-control study

Autor: David Mongan, Subash Raj Susai, Melanie Föcking, Jonah F. Byrne, Stan Zammit, Mary Cannon, David R. Cotter

Publikováno v: Mongan, D, Raj Susai, S, Föcking, M, Byrne, J F, Zammit, S, Cannon, M & Cotter, D R 2023, ' Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood: a nested case-control study ', Brain, Behavior and Immunity, vol. 111, pp. 90-100 . https://doi.org/10.1016/j.bbi.2023.03.025

BackgroundLow-grade inflammation may occur in association with several mental disorders of early adulthood, though associations with markers of chronic inflammation such as soluble urokinase plasminogen activator receptor (suPAR) are less well-establ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a71355abae3913b0615cbdcbff66c7
https://doi.org/10.1016/j.bbi.2023.03.025

Machine learning based prediction and the influence of complement - Coagulation pathway proteins on clinical outcome: Results from the NEURAPRO trial

Autor: Subash Raj Susai, David Mongan, Colm Healy, Mary Cannon, Gerard Cagney, Kieran Wynne, Jonah F. Byrne, Connie Markulev, Miriam R. Schäfer, Maximus Berger, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y.H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Rebekah Street, Andrew Thompson, Alison Ruth Yung, Barnaby Nelson, Patrick D. McGorry, Melanie Föcking, G. Paul Amminger, David Cotter

Publikováno v: Brain, behavior, and immunity, 103, 50-60. Academic Press Inc.
Raj Susai, Subash; Mongan, David; Healy, Colm; Cannon, Mary; Cagney, Gerard; Wynne, Kieran; Byrne, Jonah F; Markulev, Connie; Schäfer, Miriam R; Berger, Maximus; Mossaheb, Nilufar; Schlögelhofer, Monika; Smesny, Stefan; Hickie, Ian B; Berger, Gregor E; Chen, Eric Y H; de Haan, Lieuwe; Nieman, Dorien H; Nordentoft, Merete; Riecher-Rössler, Anita; ... (2022). Machine learning based prediction and the influence of complement-coagulation pathway proteins on clinical outcome: results from the NEURAPRO trial. Brain, behavior, and immunity, 103, pp. 50-60. Elsevier 10.1016/j.bbi.2022.03.013

BACKGROUND Functional outcomes are important measures in the overall clinical course of psychosis and individuals at clinical high-risk (CHR), however, prediction of functional outcome remains difficult based on clinical information alone. In the fir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d777dc85ad7d2524d1de2b4bd6e8a233
https://pubmed.ncbi.nlm.nih.gov/35341915