Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jonah Beenstock"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12442 (2023)
The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various cellular responses to stress conditions, inflammatory signals, and differentiation factors. They are constitutively active in chronic inflammatory diseases and so
Externí odkaz:
https://doaj.org/article/7d6cae596e684412971eb5967fbac635
Autor:
Jonah Beenstock, Samara Mishelle Ona, Jennifer Porat, Stephen Orlicky, Leo C. K. Wan, Derek F. Ceccarelli, Pierre Maisonneuve, Rachel K. Szilard, Zhe Yin, Dheva Setiaputra, Daniel Y. L. Mao, Morgan Khan, Shaunak Raval, David C. Schriemer, Mark A. Bayfield, Daniel Durocher, Frank Sicheri
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
KEOPS is an evolutionary conserved complex with a core of four core subunits—Pcc1, Kae1, Bud32 and Cgi121—that catalyzes the universal and essential tRNA modification N6-threonylcarbamoyl adenosine (t6A). Here the authors describe a Cgi121-tRNA c
Externí odkaz:
https://doaj.org/article/7cf78e57b0794aac8b3b0de7021b5c2b
Autor:
Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Ørntoft, Roger J. Davis, Ben Davidson, David Mu, Rotem Karni
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 501-513 (2014)
Summary: The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively spliced yielding two splicing isoforms with differing last exons: M
Externí odkaz:
https://doaj.org/article/bf0775f207b84a6085b0d57af787b01d
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44749 (2012)
Many protein kinases require phosphorylation at their activation loop for induction of catalysis. Mitogen-activated protein kinases (MAPKs) are activated by a unique mode of phosphorylation, on neighboring Tyrosine and Threonine residues. Whereas man
Externí odkaz:
https://doaj.org/article/2d1b40418d6346c7b1766b1b9ab3ea63
Autor:
Frank Sicheri, Jonah Beenstock
Publikováno v:
Nucleic Acids Research
KEOPS (Kinase, Endopeptidase and Other Proteins of Small size) is a five-subunit protein complex that is highly conserved in eukaryotes and archaea and is essential for the fitness of cells and for animal development. In humans, mutations in KEOPS ge
Publikováno v:
Methods in enzymology. 667
Bud32 is a member of the protein kinase superfamily that is invariably conserved in all eukaryotic and archaeal organisms. In both of these kingdoms, Bud32 forms part of the KEOPS (Kinase, Endopeptidase and Other Proteins of Small size) complex toget
Publikováno v:
Methods in Enzymology ISBN: 9780323915410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e1584f1af2ade7f1537da80010a1899
https://doi.org/10.1016/bs.mie.2022.03.052
https://doi.org/10.1016/bs.mie.2022.03.052
Autor:
Gerald D. Gish, Stephen Orlicky, Derek F. Ceccarelli, Igor Kurinov, Frank Sicheri, Susan Kelso, Jonah Beenstock
Publikováno v:
Structure
Summary Skp2 and cyclin A are cell-cycle regulators that control the activity of CDK2. Cyclin A acts as an activator and substrate recruitment factor of CDK2, while Skp2 mediates the ubiquitination and subsequent destruction of the CDK inhibitor prot
Autor:
Leo C. K. Wan, Samara Mishelle Ona, Pierre Maisonneuve, Derek F. Ceccarelli, Morgan F. Khan, Frank Sicheri, Mark A. Bayfield, Zhe Yin, Dheva Setiaputra, Rachel K. Szilard, Stephen Orlicky, Daniel Y.L. Mao, Jennifer Porat, Jonah Beenstock, Daniel Durocher, David C. Schriemer, Shaunak Raval
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The KEOPS complex, which is conserved across archaea and eukaryotes, is composed of four core subunits; Pcc1, Kae1, Bud32 and Cgi121. KEOPS is crucial for the fitness of all organisms examined. In humans, pathogenic mutations in KEOPS genes lead to G
Autor:
Arie Admon, David Engelberg, Dganit Melamed, Jonah Beenstock, Navit Mooshayef, Dafna Mordechay, Natalie G. Ahn, Benjamin P. Garfinkel
Publikováno v:
Molecular and Cellular Biology. 36:1540-1554
Many enzymes are self-regulated and can either inhibit or enhance their own catalytic activity. Enzymes that do both are extremely rare. Many protein kinases autoactivate by autophosphorylating specific sites at their activation loop and are inactiva