Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jonah A. Kaplan"'
Publikováno v:
Advanced Drug Delivery Reviews. 108:68-82
Mechanically-activated delivery systems harness existing physiological and/or externally-applied forces to provide spatiotemporal control over the release of active agents. Current strategies to deliver therapeutic proteins and drugs use three types
Publikováno v:
Angewandte Chemie International Edition. 55:2796-2800
The concept of using crack propagation in polymeric materials to control drug release and its first demonstration are reported. The composite drug delivery system consists of highly-textured superhydrophobic electrosprayed microparticle coatings, com
Autor:
Mark W. Grinstaff, Jonah A. Kaplan, Jon R. Parquette, Carlo M. Croce, Yuan Sun, Hui-Lung Sun, Aileen Shieh
Publikováno v:
Chemical Communications. 52:5254-5257
The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates wa
Publikováno v:
European Radiology. 26:866-873
To develop a breast biopsy marker that resists fast and slow migration and has permanent visibility under commonly used imaging modalities. A polymer-nanoparticle composite film was prepared by embedding superparamagnetic iron oxide nanoparticles and
Publikováno v:
New Journal of Chemistry. 39:3225-3228
The self-assembly and photo-crosslinking of a lysine dipeptide functionalized with 7-(diethylamino)-3-coumarin carboxylic acid (7-DAC) is described. Self-assembly of the dipeptide in water and PBS produces a hydrogel comprised of uniform, micrometer
Autor:
Carlo M. Croce, Hui-Lung Sun, Aileen Shieh, Yuan Sun, Mark W. Grinstaff, Jon R. Parquette, Se Hye Kim, Jonah A. Kaplan
Publikováno v:
Chemistry - A European Journal. 21:101-105
S)-Camptothecin (CPT)-conjugated dipep- tides are reported that preassemble into nanotubes with diameters ranging from 80-120 nm. These nanoassemblies maintain a high (~ 47 %) drug loading and exhibit greater drug stability (i.e., resistance to lacto
Autor:
Jonah A. Kaplan, Mark W. Grinstaff, Robert F. Padera, Yolonda L. Colson, Hongyi Lei, Rong Liu
Publikováno v:
Biomacromolecules
The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes.
Autor:
Stephan W. Anderson, Katherine M. Gallagher, Neely L. Hines, Muhammad M. Qureshi, Ashali Jain, B. Nicolas Bloch, David D. B. Bates, Maria Khalid, Mark W. Grinstaff, Karen Buch, Ariel E. Hirsch, Jonah A. Kaplan, Dianne Georgian-Smith
Publikováno v:
European radiology. 27(11)
To evaluate breast biopsy marker migration in stereotactic core needle biopsy procedures and identify contributing factors. This retrospective study analyzed 268 stereotactic biopsy markers placed in 263 consecutive patients undergoing stereotactic b
Publikováno v:
Chemical communications (Cambridge, England). 52(34)
Low molecular weight hydrogels, prepared from glycosyl–nucleoside–lipid amphiphiles, exhibit shear-thinning behaviour and reversible thermally- and mechanically-triggered sol–gel transitions. Using mechanical shear stimulation, the release of e
Autor:
Mark W. Grinstaff, Jonah A. Kaplan
Publikováno v:
Journal of Visualized Experiments.
Superhydrophobic materials, with surfaces possessing permanent or metastable non-wetted states, are of interest for a number of biomedical and industrial applications. Here we describe how electrospinning or electrospraying a polymer mixture containi