Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jona Merx"'
Autor:
Jona Merx, Jordi C. J. Hintzen, Giordano Proietti, Hidde Elferink, Yali Wang, Miriam R. B. Porzberg, Daan Sondag, Nurgül Bilgin, Jin Park, Jasmin Mecinović, Thomas J. Boltje
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Posttranslational modifications (PTMs) on histone tails regulate eukaryotic gene expression by impacting the chromatin structure and by modulating interactions with other cellular proteins. One such PTM has been identified as serine and thre
Externí odkaz:
https://doaj.org/article/d417fc4ccbb649dca6141ab06c89fcda
Autor:
Jona Merx, Rianne E. van Outersterp, Udo F. H. Engelke, Veronique Hendriks, Ron A. Wevers, Marleen C. D. G. Huigen, Huub W. A. H. Waterval, Irene M. L. W. Körver-Keularts, Jasmin Mecinović, Floris P. J. T. Rutjes, Jos Oomens, Karlien L. M. Coene, Jonathan Martens, Thomas J. Boltje
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
Combined metabolomics, NMR, and, IRIS identify biomarkers of hyperprolinemia type II (HPII) distinct from HPI and similar metabolic signatures as in patients with pyridoxine-dependent epilepsy.
Externí odkaz:
https://doaj.org/article/1073313437ec4eb190f04bb0c6441ddf
Autor:
Johan F. A. Pijnenborg, Emiel Rossing, Jona Merx, Marek J. Noga, Willem H. C. Titulaer, Nienke Eerden, Raisa Veizaj, Paul B. White, Dirk J. Lefeber, Thomas J. Boltje
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Aberrant expression of fucosylated glycans has been linked to several disease states. Control of fucose expression on live cells is needed to aid research and therapy development. Here the authors report on the development of a class of fucosylation
Externí odkaz:
https://doaj.org/article/f75d0352f311415b8d2a6f71407cf0de
Autor:
Abbas H. K. Al Temimi, Jona Merx, Christian J. van Noortwijk, Giordano Proietti, Romano Buijs, Paul B. White, Floris P. J. T. Rutjes, Thomas J. Boltje, Jasmin Mecinović
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Histone lysine methyltransferases (KMTs) play an important role in epigenetic gene regulation and have emerged as promising targets for drug discovery. However, the scope and limitation of KMT catalysis on substrates possessing substituted l
Externí odkaz:
https://doaj.org/article/d597a3d415a940e1a621ac071eda0bb4
Initial Steps towards Spatiotemporal Signaling through Biomaterials Using Click-to-Release Chemistry
Autor:
Merel Gansevoort, Jona Merx, Elly M. M. Versteeg, Isidora Vuckovic, Thomas J. Boltje, Toin H. van Kuppevelt, Willeke F. Daamen
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 1991 (2022)
The process of wound healing is a tightly controlled cascade of events, where severe skin wounds are resolved via scar tissue. This fibrotic response may be diminished by applying anti-fibrotic factors to the wound, thereby stimulating regeneration o
Externí odkaz:
https://doaj.org/article/c09c22770cc545b9b9590ab30df0fefa
Autor:
Jona Merx, Rianne E. van Outersterp, Udo F. H. Engelke, Veronique Hendriks, Ron A. Wevers, Marleen C. D. G. Huigen, Huub W. A. H. Waterval, Irene M. L. W. Körver-Keularts, Jasmin Mecinović, Floris P. J. T. Rutjes, Jos Oomens, Karlien L. M. Coene, Jonathan Martens, Thomas J. Boltje
Publikováno v:
Communications Biology, 5(1):997. Nature Publishing Group
Communications Biology, 5, 1-8
Communications Biology, 5, 1, pp. 1-8
Communications Biology, 5, 1-8
Communications Biology, 5, 1, pp. 1-8
Hyperprolinemia type II (HPII) is an inborn error of metabolism due to genetic variants in ALDH4A1, leading to a deficiency in Δ-1-pyrroline-5-carboxylate (P5C) dehydrogenase. This leads to an accumulation of toxic levels of P5C, an intermediate in
Autor:
Jona Merx, Kas J. Houthuijs, Hidde Elferink, Eva Witlox, Jasmin Mecinović, Jos Oomens, Jonathan Martens, Thomas J. Boltje, Floris P. J. T. Rutjes
Publikováno v:
Chemistry : a European Journal, 28, 1-7
Chemistry : a European Journal, 28, 9, pp. 1-7
Merx, J, Houthuijs, K, Elferink, H, Witlox, E, Mecinović, J, Oomens, J, Martens, J, Boltje, T & Rutjes, F P J T 2022, ' Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy ', Chemistry: A European Journal, vol. 28, no. 9, e202104078 . https://doi.org/10.1002/chem.202104078
Chemistry : a European Journal, 28, 9, pp. 1-7
Merx, J, Houthuijs, K, Elferink, H, Witlox, E, Mecinović, J, Oomens, J, Martens, J, Boltje, T & Rutjes, F P J T 2022, ' Characterization of Cyclic N-Acyliminium Ions by Infrared Ion Spectroscopy ', Chemistry: A European Journal, vol. 28, no. 9, e202104078 . https://doi.org/10.1002/chem.202104078
N- Acyliminium ions are highly reactive intermediates that are important for creating CC-bonds adjacent to nitrogen atoms. Here we report the characterization of cyclic N -acyliminium ions in the gas phase, generated by collision induced dissociation
Autor:
Jasmin Mecinović, Thomas J. Boltje, Paul B. White, Sabine G H A Langens, Jordi C. J. Hintzen, Jona Merx, Marijn N. Maas
Publikováno v:
Organic & Biomolecular Chemistry, 20, pp. 173-181
Organic & Biomolecular Chemistry, 20, 173-181
Hintzen, J C J, Merx, J, Maas, M N, Langens, S G H A, White, P B, Boltje, T J & Mecinović, J 2022, ' Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases ', Organic & Biomolecular Chemistry, vol. 20, no. 1, pp. 173-181 . https://doi.org/10.1039/D1OB02191E
Organic & Biomolecular Chemistry, 20, 173-181
Hintzen, J C J, Merx, J, Maas, M N, Langens, S G H A, White, P B, Boltje, T J & Mecinović, J 2022, ' Amide-derived lysine analogues as substrates and inhibitors of histone lysine methyltransferases and acetyltransferases ', Organic & Biomolecular Chemistry, vol. 20, no. 1, pp. 173-181 . https://doi.org/10.1039/D1OB02191E
Histone lysine methyltransferases and acetyltransferases are two classes of epigenetic enzymes that play pivotal roles in human gene regulation. Although they both recognise and posttranslationally modify lysine residues in histone proteins, their di
Autor:
Tessa M. A. Peters, Jona Merx, Pieter C. Kooijman, Marek Noga, Siebolt de Boer, Loes A. van Gemert, Guido Salden, Udo F. H. Engelke, Dirk J. Lefeber, Rianne E. van Outersterp, Giel Berden, Thomas J. Boltje, Rafael Artuch, Leticia Pías‐Peleteiro, Ángeles García‐Cazorla, Ivo Barić, Beat Thöny, Jos Oomens, Jonathan Martens, Ron A. Wevers, Marcel M. Verbeek, Karlien L. M. Coene, Michèl A. A. P. Willemsen
Publikováno v:
Journal of Inherited Metabolic Disease, 46, 66-75
Journal of Inherited Metabolic Disease, 46, 1, pp. 66-75
Journal of Inherited Metabolic Disease, 46, 1, pp. 66-75
We used next-generation metabolic screening to identify new biomarkers for improved diagnosis and pathophysiological understanding of glucose transporter type 1 deficiency syndrome (GLUT1DS), comparing metabolic cerebrospinal fluid (CSF) profiles fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a76900e639c776c681f4a63094b895b
https://doi.org/10.1002/jimd.12554
https://doi.org/10.1002/jimd.12554
Autor:
Daan, Sondag, Jona, Merx, Emiel, Rossing, Thomas J, Boltje, Dennis W P M, Löwik, Frank H T, Nelissen, Mark, van Geffen, Cornelis, van 't Veer, Waander L, van Heerde, Floris P J T, Rutjes
Publikováno v:
Chembiochem : a European journal of chemical biology. 23(15)
Since the outbreak of SARS-CoV-2 in December 2019 millions of infections have been reported globally. The viral chymotrypsin-like main protease (M