Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations

Autor: Serhii Aif, Nico Appold, Lucas Kampman, Oskar Hallatschek, Jona Kayser

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Antibiotic and anti-cancer therapy are challenged by mutation-mediated treatment resistance despite many mutations being maladaptive. Here, the authors introduce a system that shows how the probability of the long-term persistence of drug-resistant m

Externí odkaz: https://doaj.org/article/6f442327f45d41988c8c2115443161b6

Wie mikrobielle Modellsysteme helfen, Tumorevolution zu entschlüsseln

Autor: Maximilian Eiche, Jona Kayser

Publikováno v: BIOspektrum. 28:250-252

While cellular evolution is one of the most fundamental concepts of life, its consequences are among the most pressing issues of modern health care, including cancer and the emergence of therapy resistance. We currently still lack the ability to accu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b83981b168b0df07428b354d40cd70e0
https://doi.org/10.1007/s12268-022-1745-2

Impact of crowding on the diversity of expanding populations

Autor: Marie-Cécilia Duvernoy, Stephen Martis, Yuya Karita, Jona Kayser, Oskar Hallatschek, Carl F. Schreck, Diana Fusco

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Crowding effects are key to the self-organization of densely packed cellular assemblies, such as biofilms, solid tumors, and developing tissues. When cells grow and divide they push each other apart, remodeling the structure and extent of the populat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d851cde3696be1c7d0eade172bbd84eb
https://doi.org/10.1101/743534

Emergence of evolutionary driving forces in pattern-forming microbial populations

Autor: Oskar Hallatschek, Matti Gralka, Carl F. Schreck, QinQin Yu, Jona Kayser

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 373, iss 1747
Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1747). Royal Society of London
Kayser, J; Schreck, CF; Yu, Q; Gralka, M; & Hallatschek, O. (2018). Emergence of evolutionary driving forces in pattern-forming microbial populations. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1747), 20170106-20170106. doi: 10.1098/rstb.2017.0106. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/4gc097z0

© 2018 The Author(s) Published by the Royal Society. All rights reserved. Evolutionary dynamics are controlled by a number of driving forces, such as natural selection, random genetic drift and dispersal. In this perspective article, we aim to empha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88ca5c5b214e48f3a705b52990b48431
https://escholarship.org/uc/item/4gc097z0

The SCWISh network is essential for survival under mechanical pressure

Autor: Oskar Hallatschek, Wonjung Yoo, Jona Kayser, Morgan Delarue, Ori Hoxha, Liam J. Holt, Gregory Poterewicz, Jessica Choi

Cells that proliferate within a confined environment build up mechanical compressive stress. For example, mechanical pressure emerges in the naturally space-limited tumor environment. However, little is known about how cells sense and respond to mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d122f0463c7517c0f2a3d9d07654f68
https://doi.org/10.1101/150789