Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Jon W. Erickson"'
Autor:
Michael J. Lukey, Ahmad A. Cluntun, William P. Katt, Miao-chong J. Lin, Joseph E. Druso, Sekar Ramachandran, Jon W. Erickson, Henry H. Le, Zhihan-Emily Wang, Bryant Blank, Kai Su Greene, Richard A. Cerione
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 76-88.e7 (2019)
Summary: Efforts to target glutamine metabolism for cancer therapy have focused on the glutaminase isozyme GLS. The importance of the other isozyme, GLS2, in cancer has remained unclear, and it has been described as a tumor suppressor in some context
Externí odkaz:
https://doaj.org/article/febd3a642aa746e1bfa7a9c5d1e5c5be
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Cancer cells have previously been shown to be addicted to glutamine and glutaminase enzyme activity. Here, the authors show that overexpression of the JUN proto-oncogene in breast cancer cells regulates glutaminaseexpression and is sufficient to conf
Externí odkaz:
https://doaj.org/article/3b613416e0fb4b2589fd4ff157971900
PDF file, 48KB, Graph showing 968 potency at multiple doses when 968 is added to GAC before or after inorganic phosphate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fca221a287f2aeada0dfce66fcaafb
https://doi.org/10.1158/1535-7163.22497460
https://doi.org/10.1158/1535-7163.22497460
PDF file, 50KB, Time dependence of two compounds, 35 and 40, showing that their activity decreases when incubated with GAC for 10 or 20 minutes prior to beginning the enzymatic reaction in the assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f190e35210eb99293ff6eb5fc9d3fc7
https://doi.org/10.1158/1535-7163.22497457.v1
https://doi.org/10.1158/1535-7163.22497457.v1
PDF file, 294KB, Complete list of compounds examined in the recombinant GAC assay, and % inhibition determined against the enzyme for each compound.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8690fc081fde3a0547f615c65b71e9
https://doi.org/10.1158/1535-7163.22497451
https://doi.org/10.1158/1535-7163.22497451
One hallmark of cancer cells is their adaptation to rely upon an altered metabolic scheme that includes changes in the glycolytic pathway, known as the Warburg effect, and elevated glutamine metabolism. Glutaminase, a mitochondrial enzyme, plays a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17790b73f0aa302ede01f777e5790b6c
https://doi.org/10.1158/1535-7163.c.6535624.v1
https://doi.org/10.1158/1535-7163.c.6535624.v1
PDF file, 118KB, Graph showing dependence of 968 activity upon order in which GAC is exposed to assay reagents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93654701864f708b590b7d46426bd951
https://doi.org/10.1158/1535-7163.22497463.v1
https://doi.org/10.1158/1535-7163.22497463.v1
Autor:
Joseph E. Druso, B. Blank, Miao-chong J. Lin, Clint A. Stalnecker, Michael J. Lukey, Robert S. Weiss, Kai Su Greene, Xueying Wang, Richard A. Cerione, Chengliang Zhang, Kristin F. Wilson, Yashira L Negrón Abril, Hening Lin, Jon W. Erickson
Publikováno v:
Proc Natl Acad Sci U S A
Significance The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated in cancer cells, and a GLS-selective inhibitor is being evaluated in clinical trials. Previous screens identified succinylated lysine residues on GLS, but the function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7df8672282955596c45bf4d058b5742
https://doi.org/10.1073/pnas.1911954116
https://doi.org/10.1073/pnas.1911954116
Autor:
Kirsten L. Bryant, Wen Hsuan Chang, Thuy Tien Thi Nguyen, Channing J. Der, Jon W. Erickson, Richard A. Cerione, Marc A. Antonyak, Chia Hsin Hsu, Haoqiang Ying, Hong Jin Kim
Publikováno v:
Cancer Lett
Mutations in KRAS frequently occur in human cancer and are especially prevalent in pancreatic ductal adenocarcinoma (PDAC), where they have been shown to promote aggressive phenotypes. However, targeting this onco-protein has proven to be challenging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f697899125d2f168bc8268ade0b221bf
https://europepmc.org/articles/PMC8324551/
https://europepmc.org/articles/PMC8324551/