Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Jon W, Teague"'
Autor:
Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutat
Externí odkaz:
https://doaj.org/article/208559b87d8a4491810952fc9347c3ba
Autor:
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profi
Externí odkaz:
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f
Autor:
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with
Externí odkaz:
https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
Autor:
S M Ashiqul Islam, Irina I. Abnizova, James McKay, Yudou He, Estelle Chanudet, Behnoush Abedi-Ardekani, Dariush Nasrollahzadeh, Michael Eden, Alisa M. Goldstein, Jon W. Teague, Blandina T. Mmbaga, Nan Hu, Karl Smith-Byrne, Sandra Perdomo, Jingwei Wang, Christine Carreira, Jean-Yves Scoazec, Rebecca C. Fitzgerald, Luis Felipe Ribeiro, Michael R. Stratton, Samad Gharavi, Sergey Senkin, Erik N Bergstrom, Hiva Saffar, Sarah Moody, Sheila Coelho Soares-Lima, Pauline E Bucciarelli, Stefano Serra, Ghislaine Scelo, Charles Dzamalala, Valerie McCormack, Reza Malekzadeh, Hossein Poustchi, Valerie Gaborieau, Lia S Campos, Joshua R. Atkins, Paul Brennan, Emily Thomas, David T. Jones, Paul Richman, Farid Azmoudeh-Ardalan, Masoud Sotoudeh, Ahmadreza Niavarani, Tatsuhiro Shibata, Calli Latimer, Stephen Fitzgerald, Ludmil B Alexandrov, Ricardo Cortez Cardoso Penha, Abdolreza Fazel, Laura Humphreys, Azhar Khandekar, Arash Nikmanesh, Diana Menya
Publikováno v:
Nature Genetics. 53:1553-1563
Esophageal squamous cell carcinoma (ESCC) shows remarkable variation in incidence that is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Here w
Autor:
Matthew Hoare, Stanley W.K. Ng, Philip Robinson, Natalia Brzozowska, Mathijs A. Sanders, Nicholas Williams, Peter J. Campbell, Efterpi Nikitopoulou, Ming Yang, Natalie Birtchnell, Sarah J. Aitken, Lia Chappell, Foad J. Rouhani, Keiran Raine, Beverley Wilson, Christian Frezza, Inigo Martincorena, Simon F. Brunner, Daniel Leongamornlert, Tim H. H. Coorens, Adam Butler, Tim Butler, Jon W. Teague, Susan E. Davies, Aleksandra Ivovic, Michael R. Stratton, Raheleh Rahbari, Federico Abascal, Huw W. Naylor, Luiza Moore, Yvette Hooks
Publikováno v:
Nature, 598(7881), 473-478. Nature Publishing Group
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20–30 cancer genes1–8. Burdens of somatic mutations are higher and clonal expansions larger in chronic liver diseas
Autor:
S.M. Ashiqul Islam, Marcos Díaz-Gay, Yang Wu, Mark Barnes, Raviteja Vangara, Erik N. Bergstrom, Yudou He, Mike Vella, Jingwei Wang, Jon W. Teague, Peter Clapham, Sarah Moody, Sergey Senkin, Yun Rose Li, Laura Riva, Tongwu Zhang, Andreas J. Gruber, Christopher D. Steele, Burçak Otlu, Azhar Khandekar, Ammal Abbasi, Laura Humphreys, Natalia Syulyukina, Samuel W. Brady, Boian S. Alexandrov, Nischalan Pillay, Jinghui Zhang, David J. Adams, Iñigo Martincorena, David C. Wedge, Maria Teresa Landi, Paul Brennan, Michael R. Stratton, Steven G. Rozen, Ludmil B. Alexandrov
Publikováno v:
Cell genomics, vol 2, iss 11
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for de novo extraction of mutational signatures, and benchmark it against another 13 bioinformatics tools by using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66650f68920d43fde2ce688d861fe80
https://escholarship.org/uc/item/9b82739r
https://escholarship.org/uc/item/9b82739r
Autor:
S M Ashiqul, Islam, Marcos, Díaz-Gay, Yang, Wu, Mark, Barnes, Raviteja, Vangara, Erik N, Bergstrom, Yudou, He, Mike, Vella, Jingwei, Wang, Jon W, Teague, Peter, Clapham, Sarah, Moody, Sergey, Senkin, Yun Rose, Li, Laura, Riva, Tongwu, Zhang, Andreas J, Gruber, Christopher D, Steele, Burçak, Otlu, Azhar, Khandekar, Ammal, Abbasi, Laura, Humphreys, Natalia, Syulyukina, Samuel W, Brady, Boian S, Alexandrov, Nischalan, Pillay, Jinghui, Zhang, David J, Adams, Iñigo, Martincorena, David C, Wedge, Maria Teresa, Landi, Paul, Brennan, Michael R, Stratton, Steven G, Rozen, Ludmil B, Alexandrov
Publikováno v:
Cell genomics. 2(11)
Mutational signature analysis is commonly performed in cancer genomic studies. Here, we present SigProfilerExtractor, an automated tool for
Autor:
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell
Publikováno v:
eLife, Vol 3 (2014)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are u
Externí odkaz:
https://doaj.org/article/a97bb2e0fa0f4eb19b17cd3f405b0385
Autor:
Jean-Yves Scoazec, S M Ashiqul Islam, Irina I. Abnizova, Diana Menya, Paul Richman, Dariush Nasrollahzadeh, Michael R. Stratton, Charles Dzamalala, Sergey Senkin, Karl Smith-Byrne, Hiva Saffar, Pauline E Bucciarelli, Christine Carreira, Sarah Moody, Michael Eden, Paul Brennan, Yudou He, Lia S Campos, Azhar Khandekar, Erik N. Bergstrom, Arash Nikmanesh, Abdolreza Fazel, Ghislaine Scelo, Valerie Gaborieau, Farid Azmoudeh-Ardelan, Calli Latimer, Ricardo Cortez Cardoso Penha, Laura Humphreys, Stefano Serra, Jon W. Teague, Tatsuhiro Shibata, Ludmil B. Alexandrov, Estelle Chanudet, Masoud Sotoudeh, Jingwei Wang, Blandina T. Mmbaga, Valerie McCormack, Reza Malekzadeh, Rebecca C. Fitzgerald, Joshua R. Atkins, David T. Jones, Sandra Perdomo, Emily Thomas, Luis Felipe Ribeiro, Alisa M. Goldstein, Stephen Fitzgerald, Behnoush Abedi-Ardekani, James McKay, Nan Hu
Esophageal squamous cell carcinoma (ESCC) shows a remarkable variation in incidence which is not fully explained by known lifestyle and environmental risk factors. It has been speculated that an unknown exogenous exposure(s) could be responsible. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e3994892074c80c817477151c576fa
https://doi.org/10.1101/2021.04.29.21255920
https://doi.org/10.1101/2021.04.29.21255920
Autor:
Paul Brennan, Burcak Otlu, Sergey Senkin, Azhar Khandekar, Michael R. Stratton, Raviteja Vangara, Mike Vella, David J. Adams, Sarah Moody, Inigo Marticorena, Natalia Syulyukina, Marcos Díaz-Gay, Steven G. Rozen, Mark Barnes, Erik N. Bergstrom, Andreas J. Gruber, Tongwu Zhang, Boian S. Alexandrov, Ludmil B. Alexandrov, Yun Li, Jingwei Wang, Yudou He, Peter Clapham, Laura Humphreys, Jon W. Teague, Samuel W. Brady, Yang Wu, Nischalan Pillay, Ammal Abbasi, S M Ashiqul Islam, Jinghui Zhang, Laura Riva, David C. Wedge, Maria Teresa Landi, Christopher D. Steele
SUMMARYMutational signature analysis is commonly performed in genomic studies surveying cancer and normal somatic tissues. Here we present SigProfilerExtractor, an automated tool for accurate de novo extraction of mutational signatures for all types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4daa9c682d1ba924468a8845df9ed6bb
https://doi.org/10.1101/2020.12.13.422570
https://doi.org/10.1101/2020.12.13.422570