Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Jon Vidar Gaustad"'
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Melanoma patients with metastatic growth in the meninges have poor prognosis and few treatment options. Although treatment with BRAF inhibitors or immune checkpoint inhibitors has provided promising results, most patients with adv
Externí odkaz:
https://doaj.org/article/f2712a4d4a734033b684fe552de5049e
Autor:
Jon-Vidar Gaustad, Einar K. Rofstad
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Intratumor heterogeneity is associated with aggressive disease and poor survival rates in several types of cancer. A novel method for assessing intratumor heterogeneity in medical images, named the spatial gradient method, has been developed in our l
Externí odkaz:
https://doaj.org/article/d7ac4873a1e44338b487e8228d484eb5
Autor:
Lise Mari K. Hansem, Ruixia Huang, Catherine S. Wegner, Trude G. Simonsen, Jon-Vidar Gaustad, Anette Hauge, Einar K. Rofstad
Publikováno v:
Translational Oncology, Vol 12, Iss 8, Pp 1079-1085 (2019)
Preclinical studies have suggested that interstitial fluid pressure (IFP) is uniformly elevated in the central region of tumors, whereas clinical studies have revealed that IFP may vary among different measurement sites in the tumor center. IFP measu
Externí odkaz:
https://doaj.org/article/be564787cf2f411a8f36f373e44a8d41
Autor:
Jon-Vidar Gaustad, Einar K. Rofstad
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Tumor hypoxia is a major cause of treatment resistance and poor survival in locally-advanced cervical carcinoma (LACC). It has been suggested that Ktrans and ve maps derived by dynamic contrast-enhanced magnetic resonance imaging can provide informat
Externí odkaz:
https://doaj.org/article/0c570132302e438884517447395b95a3
Autor:
Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad
Publikováno v:
Translational Oncology, Vol 11, Iss 5, Pp 1128-1136 (2018)
Antiangiogenic treatment (AAT) used in combination with radiation therapy or chemotherapy is a promising strategy for the treatment of several cancer diseases. The vascularity and oxygenation of tumors may be changed significantly by AAT, and consequ
Externí odkaz:
https://doaj.org/article/1a785b7b66934e1eb7b2d5dc3a241198
Autor:
Catherine S. Wegner, Anette Hauge, Trude G. Simonsen, Jon-Vidar Gaustad, Lise Mari K. Andersen, Einar K. Rofstad
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 7, Pp 734-744 (2018)
The purpose of this study was dual: to investigate (a) whether sunitinib may induce changes in tumor microvasculature and hypoxia in pancreatic ductal adenocarcinoma (PDAC) and (b) whether any changes can be detected by DCE-MRI. Sunitinib-treated and
Externí odkaz:
https://doaj.org/article/3ba6ce0d1b6444f6b6380d3f36b3f7c4
Autor:
Anette Hauge, Catherine S. Wegner, Jon-Vidar Gaustad, Trude G. Simonsen, Lise Mari K. Andersen, Einar K. Rofstad
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-12 (2017)
Abstract Background Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contrast-enhanced (DCE) MRI
Externí odkaz:
https://doaj.org/article/102478f43a154b1e89e4aeaa43eb7df7
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-10 (2017)
Abstract Background Studies investigating the oxygenation status and the development of hypoxia in microscopic tumors are sparse. The purpose of this study was to measure the extent of hypoxia in microscopic melanoma xenografts and to search for poss
Externí odkaz:
https://doaj.org/article/43761314d7414c10a89c5cf76dbee7a6
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-7 (2017)
Abstract Background Studies comparing the effect of antiangiogenic agents targeting different angiogenic pathways are sparse. The purpose of this study was to compare the effect of properdistatin and sunitinib treatment in a preclinical model of mali
Externí odkaz:
https://doaj.org/article/238c927ec9314b15a8a801c3ebd5bad6
Publikováno v:
Translational Oncology, Vol 10, Iss 2, Pp 158-167 (2017)
The effect of antiangiogenic agents targeting the vascular endothelial growth factor A (VEGF-A) pathway has been reported to vary substantially in preclinical studies. The purpose of this study was to investigate the effect of sunitinib treatment on
Externí odkaz:
https://doaj.org/article/e666aa00b7ff4c43aa10f86e0bc9fb07