Zobrazeno 1 - 10
of 332
pro vyhledávání: '"Jon Timmis"'
Autor:
Mike Angus, Edgar Buchanan, Léni K. Le Goff, Emma Hart, Agoston E. Eiben, Matteo De Carlo, Alan F. Winfield, Matthew F. Hale, Robert Woolley, Jon Timmis, Andy M. Tyrrell
Publikováno v:
Frontiers in Robotics and AI, Vol 10 (2023)
The evolutionary robotics field offers the possibility of autonomously generating robots that are adapted to desired tasks by iteratively optimising across successive generations of robots with varying configurations until a high-performing candidate
Externí odkaz:
https://doaj.org/article/36617c2d2b0a467ebd468ffc9b53cd15
Publikováno v:
Frontiers in Robotics and AI, Vol 9 (2023)
Often in swarm robotics, an assumption is made that all robots in the swarm behave the same and will have a similar (if not the same) error model. However, in reality, this is not the case, and this lack of uniformity in the error model, and other op
Externí odkaz:
https://doaj.org/article/d7e92699f7ec463086367394a64bba91
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
To effectively navigate complex tissue microenvironments, immune cells sense molecular concentration gradients using G-protein coupled receptors. However, due to the complexity of receptor activity, and the multimodal nature of chemokine gradients in
Externí odkaz:
https://doaj.org/article/6eb0626067c14dae95482605da0c95c2
Autor:
Lourdes Cucurull‐Sanchez, Michael J. Chappell, Vijayalakshmi Chelliah, S. Y. Amy Cheung, Gianne Derks, Mark Penney, Alex Phipps, Rahuman S. Malik‐Sheriff, Jon Timmis, Marcus J. Tindall, Piet H. van derGraaf, Paolo Vicini, James W. T. Yates
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 259-272 (2019)
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts. This in turn undermin
Externí odkaz:
https://doaj.org/article/293fdfa59097477883b9efaa13afb99e
Autor:
Sarah Forrester, Karin Siefert, Helen Ashwin, Najmeeyah Brown, Andrea Zelmar, Sally James, Dimitris Lagos, Jon Timmis, Mitali Chatterjee, Jeremy C. Mottram, Simon L. Croft, Paul M. Kaye
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Liposomal amphotericin B (AmBisome®) as a treatment modality for visceral leishmaniasis (VL) has had significant impact on patient care in some but not all regions where VL is endemic. As the mode of action of AmBisome® in vivo is poorl
Externí odkaz:
https://doaj.org/article/b00a9e2df10b4d298ecae3b7426eb87b
Publikováno v:
Robotics, Vol 10, Iss 3, p 104 (2021)
The ability of an autonomous robot to adapt to different terrain affords the flexibility to move successfully in a range of environments. This paper proposes the Cylindabot, a transformable Wheg robot that can move with two large wheels, each of whic
Externí odkaz:
https://doaj.org/article/1ace0965ee14474dba940c01b6754115
Autor:
Paul R. Buckley, Kieran Alden, Margherita Coccia, Aurélie Chalon, Catherine Collignon, Stéphane T. Temmerman, Arnaud M. Didierlaurent, Robbert van der Most, Jon Timmis, Claus A. Andersen, Mark C. Coles
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Novel adjuvant technologies have a key role in the development of next-generation vaccines, due to their capacity to modulate the duration, strength and quality of the immune response. The AS01 adjuvant is used in the malaria vaccine RTS,S/AS01 and i
Externí odkaz:
https://doaj.org/article/5a240aa006c54bf8a92b460c8d920e74
Autor:
Junxiu Liu, Liam McDaid, Alfonso Araque, John Wade, Jim Harkin, Shvan Karim, David C. Henshall, Niamh M. C. Connolly, Anju P. Johnson, Andy M. Tyrrell, Jon Timmis, Alan G. Millard, James Hilder, David M. Halliday
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
It is now widely accepted that glia cells and gamma-aminobutyric acidergic (GABA) interneurons dynamically regulate synaptic transmission and neuronal activity in time and space. This paper presents a biophysical model that captures the interaction b
Externí odkaz:
https://doaj.org/article/e0851bf144f54bb9ab2f26f216072450
Autor:
Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy C Mottram, Simon L. Croft, Paul M. Kaye
Publikováno v:
Wellcome Open Research, Vol 3 (2019)
Background: Human visceral leishmaniasis, caused by infection with Leishmania donovani or L. infantum, is a potentially fatal disease affecting 50,000-90,000 people yearly in 75 disease endemic countries, with more than 20,000 deaths reported. Experi
Externí odkaz:
https://doaj.org/article/ae6de5004bb2437594dff34ff89d995e