Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jon T. Skare"'
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Pathogens that traffic in the blood of their hosts must employ mechanisms to evade the host innate immune system, including the complement cascade. The Lyme disease spirochete, Borreliella burgdorferi, has evolved numerous outer membrane lipoproteins
Externí odkaz:
https://doaj.org/article/d67ed208be944b309973bd65ccce22db
Autor:
Rhodaba Ebady, Alexandra F. Niddam, Anna E. Boczula, Yae Ram Kim, Nupur Gupta, Tian Tian Tang, Tanya Odisho, Hui Zhi, Craig A. Simmons, Jon T. Skare, Tara J. Moriarty
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2593-2604 (2016)
Systemic dissemination of microbes is critical for progression of many infectious diseases and is associated with most mortality due to bacterial infection. The physical mechanisms mediating a key dissemination step, bacterial association with vascul
Externí odkaz:
https://doaj.org/article/956cee04904949aa809bc808ee87e2ea
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Activation of the classical complement pathway occurs to varying degrees within strains of the Borrelia burgdorferi sensu lato complex, which contain a group of pathogenic spirochetes that cause tick-borne Lyme borreliosis, including the agent of Lym
Externí odkaz:
https://doaj.org/article/a95f3d7483444dda8e32c337995ad87e
Autor:
Ayiesha P. Barnes, Sanjay Khandelwal, Simone Sartoretto, Sooho Myoung, Samuel J. Francis, Grace M. Lee, Lubica Rauova, Douglas B. Cines, Jon T. Skare, Charles E. Booth, Brandon L. Garcia, Gowthami M. Arepally
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2656-2665
Anti-platelet factor 4 (PF4)/heparin immune complexes that cause heparin-induced thrombocytopenia (HIT) activate complement via the classical pathway. Previous studies have shown that the alternative pathway of complement substantially amplifies the
Autor:
Sourav Roy, Charles E. Booth, Alexandra D. Powell-Pierce, Anna M. Schulz, Jon T. Skare, Brandon L. Garcia
Borrelial pathogens are vector-borne etiological agents of Lyme disease, relapsing fever, andBorrelia miyamotoidisease. These spirochetes each encode several surface-localized lipoproteins that bind to components of the human complement system. BBK32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ce14c877e5491443455394bd97f7cfd
https://doi.org/10.1101/2023.03.01.530473
https://doi.org/10.1101/2023.03.01.530473
Publikováno v:
J Immunol
Complement evasion is a hallmark of extracellular microbial pathogens such as Borrelia burgdorferi, the causative agent of Lyme disease. Lyme disease spirochetes express nearly a dozen outer surface lipoproteins that bind complement components and in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b8ed6afecf1bffbea88efde9694bd3
https://europepmc.org/articles/PMC8612984/
https://europepmc.org/articles/PMC8612984/
The complement system is a proteolytic cascade involving dozens of soluble and membrane-associated proteins that function in recognition, opsonization, and elimination of foreign or damaged cells of host origin. Complement evasion is a hallmark of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f00c78f0d170e987a1e3d491d47cbf
https://doi.org/10.1101/2021.01.21.427683
https://doi.org/10.1101/2021.01.21.427683
Autor:
Jon T. Skare, Steven J. Norris, Jenifer Coburn, Brandon L. Garcia, Peter Kraiczy, Linden T. Hu, Mollie W. Jewett
Publikováno v:
Current Issues in Molecular Biology
Volume 42
Issue 1
Pages 473-518
Curr Issues Mol Biol
Volume 42
Issue 1
Pages 473-518
Curr Issues Mol Biol
Lyme disease Borrelia are obligately parasitic, tick- transmitted, invasive, persistent bacterial pathogens that cause disease in humans and non-reservoir vertebrates primarily through the induction of inflammation. During transmission from the infec
Autor:
Meghan Lybecker, Steven J. Norris, Erin B. Troy, Jenny A. Hyde, Lihui Gao, Tao Lin, Jon T. Skare, Linden T. Hu, Diana N. Medina-Pérez, Beau Wager
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008423 (2020)
PLoS Pathogens
PLoS Pathogens
Post-transcriptional regulation via small regulatory RNAs (sRNAs) has been implicated in diverse regulatory processes in bacteria, including virulence. One class of sRNAs, termed trans-acting sRNAs, can affect the stability and/or the translational e
Autor:
Sanjay Khandelwal, Sooho Samuel Myoung, Jon T. Skare, Gowthami M. Arepally, Ayiesha Barnes, Samuel Francis, Charles Booth, Brandon L. Garcia, Lubica Rauova, Douglas B. Cines, Grace M. Lee, Simone Sartoretto
Publikováno v:
Blood. 138:2076-2076
Background: Recent studies show that ultra-large immune complexes consisting of IgG and platelet factor 4 and heparin (P+H) potently activate complement and facilitate complement dependent activation of cellular FcgRIIA (PMID 34189574). In whole bloo