Zobrazeno 1 - 10
of 178
pro vyhledávání: '"Jon T. Giles"'
Autor:
Christina Charles-Schoeman, Jon T. Giles, Nancy E. Lane, Ernest Choy, Daniel E. Furst, Jiří Vencovský, Anthony G. Wilson, Gerd R. Burmester, Derek Coombs, Sara K. Penn, Nasser Khan, Jillian B. Yee, Kassim Rahawi, Iain B. McInnes
Publikováno v:
Rheumatology and Therapy, Vol 11, Iss 1, Pp 157-175 (2024)
Abstract Introduction Upadacitinib (UPA) is a Janus kinase inhibitor that has demonstrated efficacy in moderate-to-severe rheumatoid arthritis (RA) with an acceptable safety profile. We investigated laboratory parameter changes in UPA RA clinical tri
Externí odkaz:
https://doaj.org/article/7848bcb7d51248bd8d20a0519b6de718
Autor:
Daniel H. Solomon, Olga Demler, Pamela M. Rist, Leah Santacroce, Ahmed Tawakol, Jon T. Giles, Katherine P. Liao, Joan M. Bathon
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 5 (2024)
Background Cardiovascular disease remains an important comorbidity in patients with rheumatoid arthritis (RA), but traditional models do not accurately predict cardiovascular risk in patients with RA. The addition of biomarkers could improve predicti
Externí odkaz:
https://doaj.org/article/b092fe21e41540cd96d3f86f93eade11
Autor:
Joan M. Bathon, Michael Centola, Xiaoqian Liu, Zhicheng Jin, Weihua Ji, Nicholas S. Knowlton, Iván Ferraz-Amaro, Qin Fu, Jon T. Giles, Mary Chester Wasko, C. Michael Stein, Jennifer E. Van Eyk
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Cardiovascular (CV) risk estimation calculators for the general population underperform in patients with rheumatoid arthritis (RA). The purpose of this study was to identify relevant protein biomarkers that could be added to tradi
Externí odkaz:
https://doaj.org/article/f49305ff219a466d96de08cfc25c96e6
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-11 (2023)
Abstract Rheumatoid arthritis (RA) patients have a 1.5- to twofold higher risk of developing heart failure (HF) and a twofold increased risk of HF-associated mortality compared to those without RA. HF is preceded subclinically by left ventricular (LV
Externí odkaz:
https://doaj.org/article/d582c4ee2b164824b4c4f55ac13c2a9d
Autor:
Elizabeth Park, Kazato Ito, Rabia Iqbal, Isabelle Amigues, Sabahat Bokhari, Jennifer Van Eyk, Christopher Depender, Jon T. Giles, Joan Bathon
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-11 (2022)
Abstract Background Diastolic dysfunction (DD) is more prevalent in patients with rheumatoid arthritis (RA) compared to the general population. However, its evolution over time and its significant clinical predictors remain uncharacterized. We report
Externí odkaz:
https://doaj.org/article/e3f0124f1e4446f5bf82d30723e9a464
Autor:
Elizabeth Park, Jon T. Giles, Thania Perez-Recio, Paloma Pina, Christopher Depender, Yevgeniya Gartshteyn, Anca D. Askanase, Joan Bathon, Laura Geraldino-Pardilla
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, reports of its use and subsequent fatal arrhythmias in patients with coronavirus disease 19 (COVID-19
Externí odkaz:
https://doaj.org/article/24630863fe2f4553b723827f13013f04
Autor:
Jon T. Giles, Pamela M. Rist, Katherine P. Liao, Ahmed Tawakol, Zahi A. Fayad, Venkatesh Mani, Nina P. Paynter, Paul M. Ridker, Robert J. Glynn, Fengxin Lu, Rachel Broderick, Meredith Murray, Kathleen M. M. Vanni, Daniel H. Solomon, Joan M. Bathon
Publikováno v:
ACR Open Rheumatology, Vol 3, Iss 6, Pp 371-380 (2021)
Individuals with rheumatoid arthritis (RA) are at increased risk for atherosclerotic cardiovascular disease (ASCVD) events relative to the general population, potentially mediated by atherosclerotic plaques that are more inflamed and rupture prone. W
Externí odkaz:
https://doaj.org/article/e842df4b45cc4bd49735e4e8887b967e
Autor:
Christopher T. Ritchlin, Jon T. Giles, Alexis Ogdie, Juan J. Gomez‐Reino, Philip Helliwell, Pamela Young, Cunshan Wang, Joseph Wu, Ana Belén Romero, John Woolcott, Lori Stockert
Publikováno v:
ACR Open Rheumatology, Vol 2, Iss 10, Pp 543-554 (2020)
Objective Metabolic syndrome (MetS) is a cluster of concurrent risk factors for cardiovascular disease and type 2 diabetes. This post hoc analysis explored key efficacy and safety endpoints in patients with psoriatic arthritis (PsA) and MetS treated
Externí odkaz:
https://doaj.org/article/fc2e3eed87934869ad35765b8844ae75
Moving fast but going slow: coordination challenges for trials of COVID-19 post-exposure prophylaxis
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Abstract An unprecedented volume of research has been generated in response to the COVID-19 pandemic. However, there are risks of inefficient duplication and of important work being impeded if efforts are not synchronized. Excessive reliance on obser
Externí odkaz:
https://doaj.org/article/71e8441cd4544e318e4d0060bfc53829
Autor:
Erika Darrah, Jon T. Giles, Ryan L. Davis, Pooja Naik, Hong Wang, Maximilian F. Konig, Laura C. Cappelli, Clifton O. Bingham, Sonye K. Danoff, Felipe Andrade
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Objective: Peptidylarginine deiminases (PAD) 2 and 4 are key enzymes in rheumatoid arthritis (RA) pathogenesis due to their ability to generate the protein targets of anti-citrullinated protein antibodies (ACPA). Anti-PAD4 antibodies that cross-react
Externí odkaz:
https://doaj.org/article/b5c550ed653d4d0e969479c055d0a0a3