Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jon Silva"'
Autor:
Julian A. Schreiber, Melina Möller, Mark Zaydman, Lu Zhao, Zachary Beller, Sebastian Becker, Nadine Ritter, Panpan Hou, Jingyi Shi, Jon Silva, Eva Wrobel, Nathalie Strutz-Seebohm, Niels Decher, Nicole Schmitt, Sven G. Meuth, Martina Düfer, Bernhard Wünsch, Jianmin Cui, Guiscard Seebohm
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
The binding site and mechanism of action for a benzodiazepine-derivative agonist on Kv7.1 channels is determined for drug development to treat long QT syndrome.
Externí odkaz:
https://doaj.org/article/bafac49ea4894bf6810ef9961c5fb7d7
Autor:
Sherri M. Biendarra‐Tiegs, Sergey Yechikov, Bhupinder Shergill, Brittany Brumback, Kentaro Takahashi, Venktesh S. Shirure, Ruth Estelle Gonzalez, Laura Houshmand, Denise Zhong, Kuo‐Chan Weng, Jon Silva, Timothy W. Smith, Stacey L. Rentschler, Steven C. George
Publikováno v:
Physiological Reports, Vol 10, Iss 18, Pp n/a-n/a (2022)
Abstract Atrial fibrillation (AF) is the most common arrhythmia in the United States, affecting approximately 1 in 10 adults, and its prevalence is expected to rise as the population ages. Treatment options for AF are limited; moreover, the developme
Externí odkaz:
https://doaj.org/article/1096a5009d2f471fb78ff93f3a59282d
Autor:
Sherri M. Biendarra‐Tiegs, Sergey Yechikov, Bhupinder Shergill, Brittany Brumback, Kentaro Takahashi, Venktesh S. Shirure, Ruth Estelle Gonzalez, Laura Houshmand, Denise Zhong, Kuo‐Chan Weng, Jon Silva, Timothy W. Smith, Stacey L. Rentschler, Steven C. George
Publikováno v:
Physiological Reports. 10
Atrial fibrillation (AF) is the most common arrhythmia in the United States, affecting approximately 1 in 10 adults, and its prevalence is expected to rise as the population ages. Treatment options for AF are limited; moreover, the development of new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef4509831688cea1285b4d29f159278
https://doi.org/10.14814/phy2.15407
https://doi.org/10.14814/phy2.15407
Autor:
Julian A, Schreiber, Melina, Möller, Mark, Zaydman, Lu, Zhao, Zachary, Beller, Sebastian, Becker, Nadine, Ritter, Panpan, Hou, Jingyi, Shi, Jon, Silva, Eva, Wrobel, Nathalie, Strutz-Seebohm, Niels, Decher, Nicole, Schmitt, Sven G, Meuth, Martina, Düfer, Bernhard, Wünsch, Jianmin, Cui, Guiscard, Seebohm
Publikováno v:
Communications biology. 5(1)
Loss-of-function mutations in K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::887806817ade2c0976cacfab4bb80d12
https://pubmed.ncbi.nlm.nih.gov/35365746
https://pubmed.ncbi.nlm.nih.gov/35365746
Publikováno v:
Biophysical Journal. 112:103a
Background: During ischemic heart disease, pH drops from 7.4 to 6.0 within 10 minutes of onset, severely affecting ion channel gating. The cardiac sodium channel (Nav1.5) is particularly susceptible to this abrupt pH change, and its altered gating is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d420ed512667c4042ef5715c8eda14
https://doi.org/10.1016/j.bpj.2016.11.591
https://doi.org/10.1016/j.bpj.2016.11.591
Publikováno v:
Biophysical Journal. (3):424a
Oocytes lack endogenous Nav-modulating β subunits. Nav1.4α (unlike Nav1.5α) pore subunits expressed in oocytes exhibit anomalously slow, right-shifted voltage-dependent gating but co-expression with β1 subunits results in normal (i.e. more rapid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70713c1fe47ee2e87f7917f2b5c29ec2