An iPS‐derived in vitro model of human atrial conduction

Autor: Sherri M. Biendarra‐Tiegs, Sergey Yechikov, Bhupinder Shergill, Brittany Brumback, Kentaro Takahashi, Venktesh S. Shirure, Ruth Estelle Gonzalez, Laura Houshmand, Denise Zhong, Kuo‐Chan Weng, Jon Silva, Timothy W. Smith, Stacey L. Rentschler, Steven C. George

Publikováno v: Physiological Reports, Vol 10, Iss 18, Pp n/a-n/a (2022)

Abstract Atrial fibrillation (AF) is the most common arrhythmia in the United States, affecting approximately 1 in 10 adults, and its prevalence is expected to rise as the population ages. Treatment options for AF are limited; moreover, the developme

Externí odkaz: https://doaj.org/article/1096a5009d2f471fb78ff93f3a59282d

Molecular Mechanisms of Cardiacvoltage-Gated Na + Channel Regulation by Acidic pH

Autor: Wandi Zhu, Jon Silva, Bicong Li

Publikováno v: Biophysical Journal. 112:103a

Background: During ischemic heart disease, pH drops from 7.4 to 6.0 within 10 minutes of onset, severely affecting ion channel gating. The cardiac sodium channel (Nav1.5) is particularly susceptible to this abrupt pH change, and its altered gating is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3d420ed512667c4042ef5715c8eda14
https://doi.org/10.1016/j.bpj.2016.11.591

A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.

Autor: Schreiber, Julian A.^1,2 (AUTHOR), Möller, Melina¹ (AUTHOR), Zaydman, Mark³ (AUTHOR), Zhao, Lu³ (AUTHOR), Beller, Zachary³ (AUTHOR), Becker, Sebastian¹ (AUTHOR), Ritter, Nadine^1,4 (AUTHOR), Hou, Panpan³ (AUTHOR), Shi, Jingyi³ (AUTHOR), Silva, Jon³ (AUTHOR), Wrobel, Eva¹ (AUTHOR), Strutz-Seebohm, Nathalie¹ (AUTHOR), Decher, Niels⁵ (AUTHOR), Schmitt, Nicole⁶ (AUTHOR), Meuth, Sven G.⁷ (AUTHOR), Düfer, Martina^2,4 (AUTHOR), Wünsch, Bernhard^2,4 (AUTHOR), Cui, Jianmin³ (AUTHOR), Seebohm, Guiscard^1,4 (AUTHOR) guiscard.seebohm@ukmuenster.de

Publikováno v: Communications Biology. 4/1/2022, Vol. 5 Issue 1, p1-13. 13p.

Patch Trauma-Induced Kinetic Changes in Nav1.4 Channels (Oocyte Patches): Gating in Both a Nav1.4-Nav1.5 Chimera Insusceptible to β1 Modulation and a Nav1.4 Mutant Incapable of Binding G-Ankyrin is Irreversibly Modulated by Membrane Stretch

Autor: Peter F. Juranka, Wei Lin, Catherine E. Morris, Jon Silva

Publikováno v: Biophysical Journal. (3):424a

Oocytes lack endogenous Nav-modulating β subunits. Nav1.4α (unlike Nav1.5α) pore subunits expressed in oocytes exhibit anomalously slow, right-shifted voltage-dependent gating but co-expression with β1 subunits results in normal (i.e. more rapid,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70713c1fe47ee2e87f7917f2b5c29ec2

Reviewer List.

Publikováno v: Neuroscientist; Apr2022, Vol. 28 Issue 2, p194-195, 2p