Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jon S. Kauffman"'
Publikováno v:
Tetrahedron. 66:68-79
Heat-sensitive thiophosphate protecting groups derived from the alcohol 4 or 10 have provided insights in the design of DNA oligonucleotide prodrugs. Indeed, functional groups stemming from the alcohol 9, 15, 16 or 22 may be applicable to thiophospha
Autor:
Jacek Cieślak, Jon S. Kauffman, Scott E. Norris, Serge L. Beaucage, Robert J. Duff, Darón I. Freedberg, Andrzej Grajkowski
Publikováno v:
Bioconjugate Chemistry. 19:1696-1706
The functionalization of long chain alkylamine controlled-pore glass (CPG) with a 3-hydroxypropyl-(2-cyanoethyl)thiophosphoryl linker and its conversion to the support 7 has led to the synthesis of DNA oligonucleotides and their 3'- or (3',5')-conjug
Publikováno v:
The Journal of Organic Chemistry. 73:2774-2783
Emerging RNA-based technologies for controlling gene expression have triggered a high demand for synthetic oligoribonucleotides and have motivated the development of ribonucleoside phosphoramidites that would exhibit coupling kinetics and coupling ef
Autor:
Sonja Hess, Andrzej Grajkowski, John J. Snyder, Cristina Ausín, Jon S. Kauffman, John R. Lloyd, Serge L Beaucage
Publikováno v:
The Journal of Organic Chemistry. 72:805-815
Several thermolytic CpG-containing DNA oligonucleotides analogous to 1 have been synthesized to serve as potential immunotherapeutic oligonucleotide prodrug formulations for the treatment of infectious diseases in animal models. Specifically, the CpG
Autor:
Jon S. Kauffman, John Snyder, Cristina Ausín, Jacek Cieślak, Serge L. Beaucage, Marcin K. Chmielewski, ¶ and Alfred Del-Grosso
Publikováno v:
The Journal of Organic Chemistry. 70:3303-3306
When employing phosphoramidites 1a-d in the solid-phase synthesis of oligonucleoside phosphorothioates, the thermolytic 2-[N-methyl-N-(2-pyridyl)]aminoethyl thiophosphate protecting group is lost to a large extent during the course of the synthesis.
Autor:
Jon S. Kauffman
Publikováno v:
Dissolution Technologies. 12:41-43
Autor:
Cecil Dybowski, Chih Ji Tsiao, Edward E. Carroll, David R. Corbin, Lloyd Abrams, Jon S. Kauffman
Publikováno v:
The Journal of Physical Chemistry. 95:5586-5591
The interaction of xenon with zeolite rho is investigated with temperature-dependent adsorption and NMR measurements. From the results, we conclude that xenon can occupy a site at the crystallite surface, as well as sorb into the interior volume. Rap
Autor:
Andrzej Grajkowski, Darón I. Freedberg, Robert J. Duff, Jacek Cieślak, Jon S. Kauffman, Scott E. Norris, Serge L. Beaucage
Publikováno v:
Current Protocols in Nucleic Acid Chemistry
The sequential functionalization of long-chain alkylamine controlled-pore glass (CPG) with a 3-hydroxypropyl-(2-cyanoethyl)thiophosphoryl linker and a dinucleoside phosphorotetrazolide leads to a uniquely engineered support for solid-phase synthesis.
Autor:
Jon S. Kauffman, Vaidhyanathan Ramamurthy, Jonathan V. Caspar, David R. Corbin, Cecil Dybowski, David F. Eaton
Publikováno v:
Journal of Photochemistry and Photobiology A: Chemistry. 51:259-263
In this work we have utilized faujasite [2] and pentasil [3] zeolites as hosts to carry out phototransformations of several organic molecules. Although they possess completely interconnecting three dimensional pore structures these two types of zeoli
Publikováno v:
Industrial & Engineering Chemistry Research. 29:213-220
The objective of this work is to synthesize pure silicate materials through the reaction of magadiite with polyhedral, three-dimensional silica structures in order to produce novel microporous solids. We report here the results of our initial investi