Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Jon Rosen"'
Autor:
Timothy A. Barckholtz, Heather Elsen, Patricia H. Kalamaras, Gabor Kiss, Jon Rosen, Dario Bove, Emilio Audasso, Barbara Bosio
Publikováno v:
Frontiers in Energy Research, Vol 9 (2021)
Molten Carbonate Fuel Cells (MCFCs) are used today commercially for power production. More recently they have also been considered for carbon capture from industrial and power generation CO2 sources. In this newer application context, our recent stud
Externí odkaz:
https://doaj.org/article/f626d09126394f6a81fbe2aba10dcde4
Objective: To estimate amyotrophic lateral sclerosis (ALS) prevalence, 5-year survival, and explore factors associated with survival in a Medicare population. Methods: A validated administrative claims algorithm was used to classify individual’s ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af638d3a35bcd5ccaa9fd6627c4c2a3b
Autor:
Sima Vazquez, Aarti K. Jain, Bridget Nolan, Eris Spirollari, Kevin Clare, Anish Thomas, Sauson Soldozy, Syed Ali, Vishad Sukul, Jon Rosenberg, Stephan Mayer, Rakesh Khatri, Brian T. Jankowitz, Justin Singer, Chirag Gandhi, Fawaz Al-Mufti
Publikováno v:
Life, Vol 14, Iss 8, p 1049 (2024)
As the incidence of subdural hematoma is increasing, it is important to understand symptomatology and clinical variables associated with treatment outcomes and mortality in this population; patients with subdural hematoma were selected from the Natio
Externí odkaz:
https://doaj.org/article/0df520cc5e804b3aa4a892d7769a73e6
Autor:
Alis J. Dicpinigaitis, Giana Dawod, Bridget A. Nolan, Catherine A. Morse, Jon Rosenberg, Gurmeen Kaur, Ji Y. Chong, Stephan A. Mayer, Chirag D. Gandhi, Fawaz Al‐Mufti
Publikováno v:
Stroke: Vascular and Interventional Neurology, Vol 3, Iss S2 (2023)
Introduction Existing evidence remains conflicting regarding the association between oral hormonal contraceptive (OCP) use and the risk of acute ischemic stroke (AIS). Large‐scale analyses and observational data evaluating this clinical question in
Externí odkaz:
https://doaj.org/article/c211732b639a4d7fb3c4c68e33d2a324
Autor:
Feng Xu, Yoshinori Kohmura, Michael J. Zacuto, Jon Rosen, Jeremy P. Scott, Andrew D. Gibb, Mahbub Alam, David M. Tschaen
Publikováno v:
Organic Letters. 16:5422-5425
A practical synthesis of a highly functionalized tetrahydropyran DPP-4 inhibitor is described. The asymmetric synthesis relies on three back-to-back Ru-catalyzed reactions. A Ru-catalyzed dynamic kinetic resolution (DKR) reduction establishes two con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506a2870d5e7ed36caaec856133bac03
https://doi.org/10.1021/ol502661g
https://doi.org/10.1021/ol502661g
Autor:
Danny Tam, Amanda Harrison, Jason August Nachtigall, Fawn Qian, Ron Aoyama, Jon Rosen, Peter Lamb, Tao Wang, Artur Plonowski, Belinda Cancilla, Naing Aay, Elena S. Koltun, Patrick Kearney, Adam A. Galan, Arlyn Arcalas, Kwang-Ai Won, Wentao Zhang, Raju Mohan, Hongwang Du, Vicky Chan, Art Hanel, Patricia Finn, Michael Yakes, Jeff Zhang, Richards Steven J, Frauke Bentzien, John M. Nuss, Kathy Ogilvie, Christopher J. Larson
Publikováno v:
Journal of Medicinal Chemistry. 55:4322-4335
Targeting glycosphingolipid synthesis has emerged as a novel approach for treating metabolic diseases. 32 (EXEL-0346) represents a new class of glucosylceramide synthase (GCS) inhibitors. This report details the elaboration of hit 8 with the goal of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd8c748fee52922d91c2b98ea12917f
https://doi.org/10.1021/jm300122u
https://doi.org/10.1021/jm300122u
Autor:
Patricia Finn, Jeff Zhang, Patrick Kearney, Raju Mohan, Tao Wang, Peter Lamb, Vicky Chan, Danny Tam, Christopher J. Larson, Kwang-Ai Won, Adam A. Galan, Amanda Harrison, Jason August Nachtigall, Art Hanel, Jon Rosen, Richards Steven J, John M. Nuss, Naing Aay, Fawn Qian, Kevin Noson, Kathleen M. Ogilvie, Hongwang Du, Elena S. Koltun
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6773-6777
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aa3f4462e296a5ca699bcb45dea236
https://doi.org/10.1016/j.bmcl.2011.09.037
https://doi.org/10.1016/j.bmcl.2011.09.037
Autor:
Kaiguo Mo, Amit H. Shah, Peter Vollmayr, Gareth Lewis, Shannon M. Fernando, Lee Niel, D. Ashley Monks, William Y. Chang, Diptendu Chatterjee, Jeffrey N. Miner, Jon Rosen, Mei Hua Hong
Publikováno v:
Endocrinology. 150:3207-3213
The spinal nucleus of the bulbocavernosus (SNB) neuromuscular system is a highly conserved and well-studied model of sexual differentiation of the vertebrate nervous system. Sexual differentiation of the SNB is currently thought to be mediated by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d065b1704e66e20b1b980431227240d
https://doi.org/10.1210/en.2008-1478
https://doi.org/10.1210/en.2008-1478
Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist
Autor:
Kevin J. Duffy, Shin-Shay Tian, Juan I. Luengo, Elizabeth I. Valoret, Amy J. Landis, Teresa S. Sellers, Connie L. Erickson-Miller, Jon Rosen, Julian Jenkins, Christopher B. Hopson, Evelyne Delorme, Stephen G. Miller
Publikováno v:
Stem Cells (Dayton, Ohio)
Eltrombopag is a first-in-class, orally bioavailable, small-molecule, nonpeptide agonist of the thrombopoietin receptor (TpoR), which is being developed as a treatment for thrombocytopenia of various etiologies. In vitro studies have demonstrated tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500edfa6634754c5f59966f3f1116e48
http://europepmc.org/articles/PMC2729672
http://europepmc.org/articles/PMC2729672
Autor:
Sha Liu, Francisco J. López, Jon Rosen, Keith B. Marschke, Louise Y. de Grandpre, Bruce F. Bebo, Andres Negro-Vilar, Mark D. Leibowitz, Robert Ardecky, Humberto O. Viveros, Deepa Rungta, Khalid Benbatoul, Wan-Ching Yen, Jeffrey N. Miner, Lin Zhi
Publikováno v:
Endocrinology. 149:2080-2089
Treatment of inflammation is often accomplished through the use of glucocorticoids. However, their use is limited by side effects. We have examined the activity of a novel glucocorticoid receptor ligand that binds the receptor efficiently and strongl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2c4915b95aaf6d6130a65ff87afd44
https://doi.org/10.1210/en.2007-1353
https://doi.org/10.1210/en.2007-1353