Výsledky vyhledávání - "Jon R. Wiener"

Activated Src Protein Tyrosine Kinase Is Overexpressed in Late-Stage Human Ovarian Cancers

Autor: Gary E. Gallick, T. Christopher Windham, Michael T. Deavers, Peter F. Thall, Robert C. Bast, Veronica C. Estrella, Jon R. Wiener, Gordon B. Mills, Nila U. Parikh

Publikováno v: Gynecologic Oncology. 88:73-79

Objective. The objective of this study was to determine if the Src tyrosine kinase is overexpressed and activated in late-stage human ovarian cancers. Methods. Western analysis and immune complex kinase assays were performed on a panel of human ovari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2b63d49a88b1285fa4c640c022d744e
https://doi.org/10.1006/gyno.2002.6851

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Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer

Autor: Mark A. Pershouse, Yinhua Yu, Ann M. Killary, Fengji Xu, Bruce D. Cuevas, Gordon B. Mills, Yofre Cabeza-Arvelaiz, Robert C. Bast, Jon R. Wiener, M. Mercedes Lovell, Russell P. Kruzelock

Publikováno v: Oncogene. 19:6277-6285

The identity of many tumor suppressor genes important in epithelial ovarian cancer tumorigenesis remains unknown. In an effort to localize a novel tumor suppressor on chromosome 22, a psv2neo tagged human chromosome 22 was transferred into the malign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ab3cc76b9518d09c8fe0f07de66b8c
https://doi.org/10.1038/sj.onc.1204013

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Relative cytotoxic activity of immunotoxins reactive with different epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185

Autor: Robert C. Bast, Fengji Xu, Cinda M. Boyer, K. DeSombre, Kathy O'Briant, Jon R. Wiener, Blanche Simpson Bast, Lajos Pusztai, Marilee Greenwald, G. Scott Dean

Publikováno v: International Journal of Cancer. 82:525-531

Different epitopes on the extracellular domain of the HER-2 receptor can serve as distinct targets for immunotoxins. To determine the optimal epitope target for immunotoxin therapy, 7 anti-HER-2 ricin A chain murine monoclonal immunotoxins, each reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13d7da3b50ea131fca182cc3dd957b0e
https://doi.org/10.1002/(sici)1097-0215(19990812)82:4<525::aid-ijc10>3.0.co

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Expression of cell regulatory proteins in ovarian borderline tumors

Autor: B. J. Kerns, Robert C. Bast, Jon R. Wiener, Neville F. Hacker, Caroline Van Haaften-Day, Cinda M. Boyer, Debra N. Jensen, Peter Russell

Publikováno v: Cancer. 77:2092-2098

BACKGROUND Tumors of borderline malignancy are still a controversial subgroup of ovarian neoplasms. The expression of several cell regulatory proteins was studied to characterize the molecular phenotype of these tumors, and to compare them with their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa13d93d3bd8a1ca63ae742f28ea9f2e
https://doi.org/10.1002/(sici)1097-0142(19960515)77:10<2092::aid-cncr19>3.0.co

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Transfection of Ovarian Cancer Cells with Tumor Necrosis Factor-α (TNF-α) Antisense mRNA Abolishes the Proliferative Response to Interleukin-1 (IL-1) but Not TNF-α

Autor: Robert C. Bast, S. Wu, Andrew Berchuck, W.A. Merkur, Jon R. Wiener, Cinda M. Boyer

Publikováno v: Gynecologic Oncology. 53:59-63

Recombinant interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) can induce endogenous TNF-alpha mRNA expression and stimulate proliferation of epithelial ovarian cancer cells. In a previous report, proliferation induced by either cytokin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f7cc7c2ab63d8f806ad668507b9927
https://doi.org/10.1006/gyno.1994.1088

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Overexpression of the Protien Tyrosine Phosphatase PTP1B in Human Breast Cancer: Assocation With p185c-erbB-2 Protein Expression

Autor: Mark R. Conaway, Entrane L. Harvey, B. J. Kerns, Robert C. Bast, J. Dirk lglehart, Andrew Berchuck, Jon R. Wiener

Publikováno v: JNCI Journal of the National Cancer Institute. 86:372-378

BACKGROUND The p185c-erbB-2 growth factor receptor protein tyrosine kinase (PTK) is overexpressed in one third of human breast cancer patients and indicates a poor prognosis in these patients. Protein tyrosine phosphatases (PTPs) may balance PTK acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7a8e7eedb380946b775f10cbb9fb1b
https://doi.org/10.1093/jnci/86.5.372

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Nonreceptor Tyrosine Kinases and Their Roles in Cancer

Autor: Gary E. Gallick, Jon R. Wiener

Publikováno v: Signaling Pathways in Cancer Pathogenesis and Therapy ISBN: 9781461412151

From studies on tumor development in animals to identification of the first oncogene, the Src family of nonreceptor tyrosine kinases has been a focus of intense biological and medical interest for over 100 years. Aberrant signaling through Src and it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::523e7c6e882dac3d9ee467aeb0208e11
https://doi.org/10.1007/978-1-4614-1216-8_4

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Cell growth regulation in epithelial ovarian cancer

Autor: Feng Ji Xu, Jon R. Wiener, Robert C. Bast, Ian Jacobs, Cinda M. Boyer, Shu Wu, Andrew Berchuck, Matt Kohler

Publikováno v: Cancer. 71:1597-1601

BACKGROUND: As in the case of other epithelial neoplasms, most ovarian cancers arise from single clones of cells that have undergone multiple genetic alterations. A comparison of normal and malignant ovarian epithelium has identified several differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5de672f82c9a3634acf7bde01adebb41
https://doi.org/10.1002/cncr.2820710426

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Biology and therapy with biologic agents in gynecologic cancer

Autor: Andrew Berchuck, Jon R. Wiener, Robert C. Bast

Publikováno v: Current Opinion in Oncology. 4:946-954

Growth of epithelial ovarian cancer is influenced by several factors including transforming growth factor-alpha and transforming growth factor-beta, macrophage colony stimulating factor, tumor necrosis factor-alpha, interleukin-1 and interleukin-6, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6510c752c609125d6d8e0e9ba692dc97
https://doi.org/10.1097/00001622-199210000-00020

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Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway

Autor: Terri B. Pustilnik, Fazal H. Tabassam, Astrid Eder, Jon R. Wiener, Gordon B. Mills, Shuying Liu, Gary E. Gallick, Veronica C. Estrella, Francois Xavier Claret

Publikováno v: International Journal of Oncology.

Lysophosphatidic acid (LPA) is an important intercellular signaling molecule involved in a myriad of biological responses. Elevated concentrations of LPA are present in the ascites and plasma of ovarian cancer patients suggesting a role for LPA in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df2e28b7aeead8d68feb4c45180f2850
https://doi.org/10.3892/ijo.31.2.441

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