Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jon R. Armstrong"'
Autor:
Ian Schillebeeckx, Jon Earls, Kevin C. Flanagan, Jeffrey Hiken, Alex Bode, Jon R. Armstrong, David N. Messina, Douglas Adkins, Jessica Ley, Ilaria Alborelli, Philip Jermann, Jarret I. Glasscock
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Anti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response. To build a better biomarker, we created a method called T Cell Subtype Profiling (TCSP) th
Externí odkaz:
https://doaj.org/article/70f2735d0a29419c91b35c3e0704e00b
Autor:
Agnes P. Chan, Azeem Siddique, Yvain Desplat, Yongwook Choi, Sridhar Ranganathan, Kumari Sonal Choudhary, M. Faizan Khalid, Josh Diaz, Jon Bezney, Dante DeAscanis, Zenas George, Shukmei Wong, William Selleck, Jolene Bowers, Victoria Zismann, Lauren Reining, Sarah Highlander, Keith Brown, Jon R. Armstrong, Yaron Hakak, Nicholas J. Schork
Publikováno v:
Cell Reports Methods. 3:100463
Autor:
Agnes P. Chan, Azeem Siddique, Yvain Desplat, Yongwook Choi, Sridhar Ranganathan, Kumari Sonal Choudhary, Josh Diaz, Jon Bezney, Dante DeAscanis, Zenas George, Shukmei Wong, William Selleck, Jolene Bowers, Victoria Zismann, Lauren Reining, Sarah Highlander, Yaron Hakak, Keith Brown, Jon R. Armstrong, Nicholas J. Schork
The lack of preparedness for detecting the highly infectious SARS-CoV-2 pathogen, the pathogen responsible for the COVID-19 disease, has caused enormous harm to public health and the economy. It took ∼60 days for the first reverse transcription qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb0c4b4a6294c3dcbafcaf539a00ac65
https://doi.org/10.1101/2022.05.12.22274799
https://doi.org/10.1101/2022.05.12.22274799
Autor:
Kevin C. Flanagan, Tiange Cui, Jon Earls, Jason T. Forys, David N. Messina, Jarret Glasscock, Ian Schillebeeckx, Jon R. Armstrong, Eric J. Duncavage, Jeffrey F. Hiken
Publikováno v:
The Journal of Molecular Diagnostics. 22:555-570
As immuno-oncology drugs grow more popular in the treatment of cancer, better methods are needed to quantify the tumor immune cell component to determine which patients are most likely to benefit from treatment. Methods such as flow cytometry can acc
Autor:
Ian Schillebeeckx, Jon Earls, Kevin C. Flanagan, Jeffrey Hiken, Alex Bode, Jon R. Armstrong, David N. Messina, Douglas Adkins, Jessica Ley, Ilaria Alborelli, Philip Jermann, Jarret I. Glasscock
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Anti-PD-1 therapy can provide long, durable benefit to a fraction of patients. The on-label PD-L1 test, however, does not accurately predict response. To build a better biomarker, we created a method called T Cell Subtype Profiling (TCSP) that charac
Autor:
Christina M. Lockwood, Kymberlie H. Pepin, Shashikant Kulkarni, Ryan J. Bloom, John D. Pfeifer, Priya Velu, Julie Branson, Samantha N. McNulty, Ramaswamy Govindan, Eric J. Duncavage, Jason T. Forys, Catherine E. Cottrell, Jason N. Rosenbaum, Haley J. Abel, Jon R. Armstrong, Eric Q. Konnick, Jeff Hiken
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 31(5)
In lung adenocarcinoma, canonical EML4-ALK inversion results in a fusion protein with a constitutively active ALK kinase domain. Evidence of ALK rearrangement occurs in a minority (2-7%) of lung adenocarcinoma, and only ~60% of these patients will re
Autor:
Nils Becker, Jon R. Armstrong, Vincent Magrini, Eric J. Duncavage, Haley J. Abel, John D. Pfeifer
Publikováno v:
Bioinformatics. 26:2684-2688
Motivation: Targeted ‘deep’ sequencing of specific genes or regions is of great interest in clinical cancer diagnostics where some sequence variants, particularly translocations and indels, have known prognostic or diagnostic significance. In thi
Autor:
Monique Gaudreault, Jon R. Armstrong, Jennifer A. Loughman, Stephanie A. Fritz, Patricia Sellenriek, Gregory A. Storch, Elaine R. Mardis, Rachel C Orscheln, David A. Hunstad, Emily K. Storch, Kimberly Mitchell
Publikováno v:
Clinical Infectious Diseases. 49:536-542
Background. Within the current worldwide epidemic of community-acquired Staphylococcus aureus infections, attention has focused on the role of methicillin-resistant strains. We characterize methicillin-susceptible strains that also contribute to this
Autor:
Carolyn L. Cannon, Richard S. Buller, Gregory A. Storch, Elaine R. Mardis, Arnon Elizur, Rachel C Orscheln, Jeffrey J. Atkinson, Thomas W. Ferkol, Jon R. Armstrong, W. Michael Dunne
Publikováno v:
Chest. 131:1718-1725
Background Panton-Valentine Leukocidin-expressing (PVL+) methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen worldwide causing fatal necrotizing pneumonias in otherwise healthy individuals but has not been described in patients
Autor:
Richard S. Buller, Gregory A. Storch, Jon R. Armstrong, W. Michael Dunne, Elaine R. Mardis, Robert S. Liao, Rachel C Orscheln
Publikováno v:
Journal of Clinical Microbiology. 44:2254-2257
We performed a blinded study to compare repetitive-sequence PCR and multilocus sequence typing for genotyping hospital- and community-acquired methicillin-resistant Staphylococcus aureus (MRSA). The MRSA strains that were sequence type 8 (ST8), staph