Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jon R, Polansky"'
Autor:
Jon R. Polansky
Publikováno v:
Ophthalmology Clinics of North America. 16:515-527
Over the past several years, many groups worldwide have confirmed the presence of probable disease-causing mutations in the coding region of the (TIGR/MYOC) gene associated with glaucoma. Disease-associated point mutations are often found in the thir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94c712ce6c78080f541e735640f3a328
https://doi.org/10.1016/s0896-1549(03)00068-3
https://doi.org/10.1016/s0896-1549(03)00068-3
Publikováno v:
Eye. 14:503-514
Glucocorticoid (GC) treatment of human trabecular meshwork (HTM) cells produces delayed, progressive cellular and extracellular protein/glycoprotein inductions with characteristics matching those for intraocular pressure elevation with corticosteroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbfe214c77800791ed90387af2204ab
https://doi.org/10.1038/eye.2000.137
https://doi.org/10.1038/eye.2000.137
Autor:
Jon R. Polansky
Publikováno v:
Ophthalmology Clinics of North America. 13:111-121
The frontier of genetic testing in ophthalmology, including the availability of a variety of tests to screen for genetic alterations that appear causally related to the development of glaucoma in adults as well as in children, is advancing. The knowl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916dea610b1cba9dda04b9b393abec13
https://doi.org/10.1016/s0896-1549(05)70170-x
https://doi.org/10.1016/s0896-1549(05)70170-x
Publikováno v:
Journal of Drug Targeting. 7:413-421
Non-viral gene therapy is a potential treatment to many incurable retinal diseases. To fulfill this promise, plasmid DNA must be delivered to the retinal target cells. We evaluated the efficacy of synthetic DNA complexing compounds in transfecting pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8661f167c81a685e2c0c08ed390bf9ca
https://doi.org/10.3109/10611860009102216
https://doi.org/10.3109/10611860009102216
Publikováno v:
Current Eye Research. 19:517-524
Decreased flow of aqueous humor through the trabecular meshwork (TM) and into Schlemm's canal (SC) is believed to be a predominant factor in the development of the elevated intraocular pressure found in primary open-angle and steroid glaucoma. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb116f84b29044964d3bfd34e68a237
https://doi.org/10.1076/ceyr.19.6.517.5285
https://doi.org/10.1076/ceyr.19.6.517.5285
Autor:
Christian Y. Mardin, Wido M. Budde, Gottfried O. H. Naumann, Thomas Liehr, C. Van Broeckhoven, Karin Michels-Rautenstrauss, Thai Nguyen, Bernd Rautenstrauss, Rudolf A. Pfeiffer, Vincent Timmerman, Jon R. Polansky
Publikováno v:
Human genetics
Autosomal dominant juvenile open angle glaucoma (JOAG) is an early-onset form of primary open angle glaucoma (POAG), which has been linked to chromosome 1q21-q31. Recently, mutations in the trabecular meshwork inducible glucocorticoid response gene (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72df267a51a60c767fbaa0e93a7ad6f3
https://doi.org/10.1007/s004390050661
https://doi.org/10.1007/s004390050661
Autor:
Pu Chen, Donald J. Fauss, Ernest Bloom, Jon R. Polansky, Ron M. Kurtz, Elke Lütjen-Drecoll, Thai Nguyen, Hua Chen, Zhi-Dong Ma, Douglas H. Johnson
Publikováno v:
Ophthalmologica. 211:126-139
Studies of the effects of glucocorticoid (GC) and oxidative stress stimuli in differentiated cultures of human trabecular meshwork (HTM) cells have provided the rationale for our studies of a major new gene termed TIGR (trabecular meshwork inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb4cf60ce332739c103913813cdaca6
https://doi.org/10.1159/000310780
https://doi.org/10.1159/000310780
Publikováno v:
Current Eye Research. 15:137-143
The effects of natriuretic peptides on cGMP formation and [125I]ANP binding in human trabecular meshwork cells were investigated. CNP at 1 microM stimulated cGMP formation approximately 18-25 fold, with a half maximal effective concentration approxim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030c05515d7db4e953ad98e379c55167
https://doi.org/10.3109/02713689608997406
https://doi.org/10.3109/02713689608997406
Publikováno v:
Experimental Eye Research. 55:785-795
Thrombin at concentrations as low as 20 p m (0·002 U ml−1) was found to stimulate inositol phosphate levels in cultured human non-pigmented ciliary epithelial cells. Several other proteases, including trypsin and plasmin, had little or no effect,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab105e1ffbba80960db681b4358d77c
https://doi.org/10.1016/0014-4835(92)90005-d
https://doi.org/10.1016/0014-4835(92)90005-d
Autor:
Jon R. Polansky
Publikováno v:
Current Opinion in Ophthalmology. 3:259-272
Anti-inflammatory corticosteroids and β-blockers remain two of the most widely prescribed classes of drugs in ophthalmology despite their well-known ocular and systemic side effects. For corticosteroids, studies of ocular drug levels and corneal ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a145b59ac4de1c803338e44192ad2e11
https://doi.org/10.1097/00055735-199204000-00018
https://doi.org/10.1097/00055735-199204000-00018