Genetic Variation in the Social Environment Contributes to Health and Disease

Autor: Jesse Ingels, Jon P. Krohn, Jacques Callebert, Robert W. Williams, Amelie Baud, Jean-Marie Launay, Megan K. Mulligan, Andres Legarra, Casey J. Bohl, Francesco Paolo Casale, Oliver Stegle

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2017, 13 (1), Non paginé. ⟨10.1371/journal.pgen.1006498⟩
Plos Genetics 1 (13), Non paginé. (2017)
PLoS Genetics, Vol 13, Iss 1, p e1006498 (2017)

Assessing the impact of the social environment on health and disease is challenging. As social effects are in part determined by the genetic makeup of social partners, they can be studied from associations between genotypes of one individual and phen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68454b4065605232a742d130fcbbfe13
https://hal.archives-ouvertes.fr/hal-01603345

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Autor: Lynn Quek, Anne Goriely, Ondrej Cais, Christopher Yau, Lars Fugger, John Broxholme, Niko Popitsch, David Beeson, Zoya Kingsbury, M. Andrew Nesbit, David J. Nutt, Christopher Holmes, Andrew J. Rimmer, Fredrik Karpe, John Taylor, Andrea H. Németh, Veronica J. Buckle, Rodney D. Gilbert, Natasha Sahgal, Sian E. Piret, Alistair T. Pagnamenta, Elizabeth Sweeney, Stefano Lise, Sarah Lamble, Moustafa Attar, Christian Babbs, Mary Frances McMullin, Adrian V. S. Hill, Ingo H. Greger, Per Soelberg Sørensen, Michael P. Whyte, Paolo Piazza, Lorna Witty, Lorne Lonie, Emma E. Davenport, Peter J. Ratcliffe, Peter Humburg, Simon J. McGowan, Holger Cario, Chris Allan, Usha Kini, Malcolm F. Howard, Alexandra Russo, Simon Fiddy, Fiona Powrie, Pauline A. van Schouwenburg, Jude Craft, Andrew O.M. Wilkie, Aimee L. Fenwick, Jennifer Becq, Elizabeth Ormondroyd, Nayia Petousi, Richard R. Copley, Joshua Luck, David Buck, Hilary C. Martin, Katherine R. Bull, Holm H. Uhlig, Russell J. Grocock, Timothy J. Vyse, Smita Y. Patel, Gerton Lunter, Sean Humphray, Helen Chapel, Peter Donnelly, Karin Dahan, Calliope A. Dendrou, Edward Blair, Peter A. Robbins, Davis J. McCarthy, Kerry A. Miller, Rajesh V. Thakker, A. Radu Aricescu, Gilean McVean, Alison Simmons, Annette Bang Oturai, Julian C. Knight, David W. Johnson, Craig B. Langman, Earl D. Silverman, Anja V. Gruszczyk, Olivier Devuyst, Jean-Baptiste Cazier, Paresh Vyas, John I. Bell, Kathryn J. H. Robson, Ian Tomlinson, Jenny C. Taylor, Amy Trebes, Anna Schuh, Linda Hughes, Stephen R.F. Twigg, Hugh Watkins, Celeste Bento, Melanie J. Percy, Robert W. Hastings, Jonathan Flint, Richard J. Cornall, Edouard Hatton, Doug Higgs, P Bignell, Guadalupe Polanco-Echeverry, Angie Green, Jon P. Krohn, Ben Wright, David Bentley, Christopher W. Pugh, Steven A. Wall, Lisa Murray, Alexander Kanapin

Publikováno v: Nat Genet
Nature genetics
Taylor, J C, Martin, H C, Lise, S, Broxholme, J, Cazier, J-B, Rimmer, A, Kanapin, A, Lunter, G, Fiddy, S, Allan, C, Aricescu, A R, Attar, M, Babbs, C, Becq, J, Beeson, D, Bento, C, Bignell, P, Blair, E, Buckle, V J, Bull, K, Cais, O, Cario, H, Chapel, H, Copley, R R, Cornall, R, Craft, J, Dahan, K, Davenport, E E, Dendrou, C, Devuyst, O, Fenwick, A L, Flint, J, Fugger, L, Gilbert, R D, Goriely, A, Green, A, Greger, I H, Grocock, R, Gruszczyk, A V, Hastings, R, Hatton, E, Higgs, D, Hill, A, Holmes, C, Howard, M, Hughes, L, Humburg, P, Johnson, D, Karpe, F, Kingsbury, Z, Kini, U, Knight, J C, Krohn, J, Lamble, S, Langman, C, Lonie, L, Luck, J, McCarthy, D, McGowan, S J, McMullin, M F, Miller, K A, Murray, L, Németh, A H, Nesbit, M A, Nutt, D, Ormondroyd, E, Oturai, A B, Pagnamenta, A, Patel, S Y, Percy, M, Petousi, N, Piazza, P, Piret, S E, Polanco-Echeverry, G, Popitsch, N, Powrie, F, Pugh, C, Quek, L, Robbins, P A, Robson, K, Russo, A, Sahgal, N, van Schouwenburg, P A, Schuh, A, Silverman, E, Simmons, A, Sørensen, P S, Sweeney, E, Taylor, J, Thakker, R V, Tomlinson, I, Trebes, A, Twigg, S R F, Uhlig, H H, Vyas, P, Vyse, T, Wall, S A, Watkins, H, Whyte, M P, Witty, L, Wright, B, Yau, C, Buck, D, Humphray, S, Ratcliffe, P J, Bell, J I, Wilkie, A O M, Bentley, D, Donnelly, P & McVean, G 2015, ' Factors influencing success of clinical genome sequencing across a broad spectrum of disorders ', Nature Genetics, vol. 47, no. 7, pp. 717-26 . https://doi.org/10.1038/ng.3304

To assess factors influencing the success of whole-genome sequencing for mainstream clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families across a broad spectrum of disorders in whom previous screening had identified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264c462e19ca02924993dc0e5f946c23
https://doi.org/10.1038/ng.3304

Supplementary Material 1

Autor: Henry Völzke, Tõnu Esko, Ken K. Ong, Aldi T. Kraja, Anne U. Jackson, Meena Kumari, Eva Albrecht, Rona J. Strawbridge, Antti Jula, Mark J. Caulfield, Alistair S. Hall, Karol Estrada, Jennifer L. Bolton, Teresa Ferreira, Inger Njølstad, Thomas W. Winkler, Ross M. Fraser, Daniel I. Chasman, Maris Teder-Laving, Yii-Der Ida Chen, Claudia Langenberg, Kevin B. Jacobs, Jennifer G. Sambrook, Evelin Mihailov, Peter Kovacs, Susanne Moebus, Jouke-Jan Hottenga, George Dedoussis, Gudmar Thorleifsson, Sirkka M. Keinanen Kiukaanniemi, Matti Uusitupa, Denise Anderson, Lindsay L. Waite, Johan G. Eriksson, Mustafa Atalay, Kari Stefansson, Amélie Bonnefond, Gerry Fowkes, Tove Fall, Dmitry Shungin, Stephan J. L. Bakker, Tamara B. Harris, Thomas Illig, Wolfgang Koenig, Heribert Schunkert, Caroline S. Fox, Gabrielle Boucher, Sonja I. Berndt, Timo Saaristo, Maria Dimitriou, Pim van der Harst, Christina Loley, John Yarnell, Rainer Rauramaa, Sarah Edkins, Jaakko Tuomilehto, Karen L. Mohlke, Damien C. Croteau Chonka, Reedik Mägi, Olli T. Raitakari, Kathleen Stirrups, Aroon D. Hingorani, Inga Prokopenko, Henrik Grönberg, Marcus E. Kleber, Massimo Mangino, Michael A. Province, Markus M. Nöthen, Patricia B. Munroe, Francis S. Collins, Jeanette Erdmann, Mattias Lorentzon, Lynda M. Rose, Jon P. Krohn, Paul M. Ridker, M. Carola Zillikens, Jouko Saramies, Andrew Wong, Anuj Goel, Christa Buechler, Chris Power, Iain Mathieson, Bernhard O. Boehm, Jonathan Tyrer, Fredrik Karpe, Lu Qi, Nicholas G. Martin, Kristian Hveem, Jackie F. Price, Martin Farrall, Albert V. Smith, Mary F. Feitosa, Caroline Hayward, Juha Sinisalo, Stavroula Kanoni, Elina Hyppönen, Christian Hengstenberg, Lori L. Bonnycastle, Ilja M. Nolte, Sonali Pechlivanis, Barbara Thorand, Patrik K. E. Magnusson, Cristina Barlassina, Andrew A. Hicks, Genovefa Kolovou, Melanie M. van der Klauw, Markus Perola, Tsegaselassie Workalemahu, Ida Surakka, Veikko Salomaa, Andrea Ganna, Timothy M. Frayling, Iris M. Heid, Brenda W.J.H. Penninx, Stephen J. Chanock, Jeffrey R. O'Connell, Tom Wilsgaard, Alan R. Shuldiner, David J. Hunter, Deborah J. Clegg, Toby Johnson, Cornelia M. van Duijn, Samuli Ripatti, David P. Strachan, Lyle J. Palmer, Alexander Teumer, Kari E. North, L. Adrienne Cupples, Carlos Iribarren, Anna-Liisa Hartikainen, Andrew R. Wood, Lambertus A. Kiemeney, Ulf Gyllensten, Jennie Hui, Tim D. Spector, Paul W. Franks, Andrew D. Morris, Ruth J. F. Loos, George Nicholson, Felix R. Day, Kati Kristiansson, Talin Haritunians, Martina Müller-Nurasyid, Sailaja Vedantam, Pablo V. Gejman, Martin den Heijer, Andrea Maschio, Anke Tönjes, Kari Kuulasmaa, Raimund Erbel, Markku Laakso, Devin Absher, Narisu Narisu, Zhaoming Wang, Jing Hua Zhao, Thomas N. Person, Irene Mateo Leach, Mark I. McCarthy, Albert Hofman, Joel N. Hirschhorn, H.-Erich Wichmann, Nicholas J. Wareham, André Scherag, Jarmo Virtamo, James F. Wilson, Gonçalo R. Abecasis, Winfried März, Nilesh J. Samani, Timo A. Lakka, Jacques S. Beckmann, Harold Snieder, Adam E. Locke, Hanneke Basart, Grant W. Montgomery, Robert C. Kaplan, Claudia Lamina, Sekar Kathiresan, Mika Kivimäki, Leif Groop, Emil Rehnberg, Jana V. Van Vliet Ostaptchouk, Ingrid B. Borecki, Sabrina Bauer, Terho Lehtimäki, Steve E. Humphries, Zoltán Kutalik, Kees Hovingh, Carolina Medina-Gomez, Panos Deloukas, Antony P. Attwood, Kay-Tee Khaw, Per Hall, Jaakko Kaprio, Jian Yang, Tuomas O. Kilpeläinen, Andres Metspalu, Igor Rudan, Michael Boehnke, Ben A. Oostra, Jaana Lindström, André G. Uitterlinden, Peter Schwarz, Keri L. Monda, John Beilby, Fernando Rivadeneira, Emmanouil T. Dermitzakis, Dominique Arveiler, Valgerdur Steinthorsdottir, Jian'an Luan, Cecilia M. Lindgren, Guo Li, Bruna Gigante, Göran Hallmans, Liming Liang, Peter S. Chines, Sarah E. Medland, Joseph Hung, Peter P. Pramstaller, Ulf de Faire, Joshua C. Randall, Nancy L. Pedersen, Wendy L. McArdle, Unnur Thorsteinsdottir, Bernhard R. Winkelmann, Kaarel KrjutÅ¡kov, Philippe Froguel, Harry Campbell, Dorret I. Boomsma, Harald Grallert, Nancy L. Heard Costa, Shengxu Li, Amy J. Swift, Diana Kuh, Gerjan Navis, Christian Gieger, Heikki V. Huikuri, Niina Eklund, Anders Hamsten, Elizabeth K. Speliotes, Josine L. Min, Hendrik B. Sager, Stefan Gustafsson, Antigone S. Dimas, Elena Tremoli, Carlo Rivolta, Jianxin Shi, Najaf Amin, Claes Ohlsson, Johanna Kuusisto, Giancarlo Cesana, Lars Lind, Stefan R. Bornstein, Erik Ingelsson, Colin N. A. Palmer, Marjo-Riitta Järvelin, Krista Fischer, Annette Peters, David Schlessinger, Themistocles L. Assimes, Inês Barroso, Kristina Eisinger, Marja-Liisa Lokki, Jennifer Jolley, Åsa Johansson

Publikováno v: Tel Aviv: Journal of the Institute of Archaeology of Tel Aviv University.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6882ff4c3b9598ba55c6f0d68484fc9
https://doi.org/10.1179/033443513x13612671397305.s1