Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jon M. Huibregtse"'
Autor:
Xu Zhao, Jessica M. Perez, Peter A. Faull, Catherine Chan, Femke W. Munting, Larissa A. Canadeo, Can Cenik, Jon M. Huibregtse
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108820- (2024)
Summary: ISG15 is a type I interferon-induced ubiquitin-like modifier that functions in innate immune responses. The major human ISG15 ligase is hHERC5, a ribosome-associated HECT E3 that broadly ISGylates proteins cotranslationally. Here, we charact
Externí odkaz:
https://doaj.org/article/bea97f0a716b4da698a414645be006b8
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Human papilloma virus (HPV) E7 protein destabilizes the retinoblastoma protein (Rb) by inducing its ubiquitination in cervical cancer cells, however proteasomal degradation requires cleavage of Rb after Lys 810 and so far it has been unclear how Rb c
Externí odkaz:
https://doaj.org/article/efa1fd80046b433d9c08b09e1c821f0f
Autor:
Caleb D. Swaim, Varun Dwivedi, Yi-Chieh Perng, Xu Zhao, Larissa A. Canadeo, Houda H. Harastani, Tamarand L. Darling, Adrianus C.M. Boon, Deborah J. Lenschow, Viraj Kulkarni, Jon M. Huibregtse
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103213- (2021)
Summary: The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attra
Externí odkaz:
https://doaj.org/article/2d628d8bb0d24099b4370a53d4b95c2c
Autor:
Caleb D. Swaim, Larissa A. Canadeo, Kristen J. Monte, Swati Khanna, Deborah J. Lenschow, Jon M. Huibregtse
Publikováno v:
Cell Reports, Vol 31, Iss 11, Pp 107772- (2020)
Summary: ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-γ release from natural killer (NK) and T cells. The signals that lead to the production of extracellula
Externí odkaz:
https://doaj.org/article/1854af2558b842cb99f3093f6d49f81a
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications
Nature Communications
Retinoblastoma protein (Rb) is a tumor suppressor that binds and represses E2F transcription factors. In cervical cancer cells, human papilloma virus (HPV) protein E7 binds to Rb, releasing it from E2F to promote cell cycle progression, and inducing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cafdc292f9ac3f7a590f36ab3c7bcd
http://link.springer.com/article/10.1038/s41467-020-16003-3
http://link.springer.com/article/10.1038/s41467-020-16003-3
Autor:
Larissa A. Canadeo, Caleb D. Swaim, Deborah J. Lenschow, Yi-Chieh Perng, Houda H. Harastani, Xu Zhao, Jon M. Huibregtse, Adrianus C. M. Boon, Tamarand L. Darling
Publikováno v:
bioRxiv
A recently emerged betacoronavirus, SARS-CoV-2, has led to a global health crisis that calls for the identification of effective therapeutics for COVID-19 disease. Coronavirus papain-like protease (PLpro) is an attractive drug target as it is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97bff3018263f2a3facd280e4cdce757
https://europepmc.org/articles/PMC7337375/
https://europepmc.org/articles/PMC7337375/
Autor:
Antony Harvey, Oshadi Wimalarathne, Peter R. Mueller, Rose Stewart, Ji-Hoon Lee, Tanya T. Paull, Jon M. Huibregtse, Carlos P. Zanini, Nicolette A. Ender, Seung Woo Ryu, Chase Pectol
The HSP70 family of chaperones are the front-line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of clients to maintain cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0912db619440b04a5eb19a7c083e2e5b
https://doi.org/10.1101/865030
https://doi.org/10.1101/865030
Autor:
Eric R Weiss, Elena Popova, Hikaru Yamanaka, Hyung Cheol Kim, Jon M Huibregtse, Heinrich Göttlinger
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001107 (2010)
Retroviruses engage the ESCRT pathway through late assembly (L) domains in Gag to promote virus release. HIV-1 uses a PTAP motif as its primary L domain, which interacts with the ESCRT-I component Tsg101. In contrast, certain other retroviruses prima
Externí odkaz:
https://doaj.org/article/0d0e45f261764a47ab89d8ff1e1d8041
Autor:
Larissa A. Canadeo, Caleb D. Swaim, Adrianus C. M. Boon, Deborah J. Lenschow, Yi-Chieh Perng, Xu Zhao, Viraj Kulkarni, Tamarand L. Darling, Houda H. Harastani, Jon M. Huibregtse, Varun Dwivedi
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103213-(2021)
iScience
iScience
The emergence of SARS-CoV-2 has led to a global health crisis that, in addition to vaccines and immunomodulatory therapies, calls for the identification of antiviral therapeutics. The papain-like protease (PLpro) activity of nsp3 is an attractive dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cc2c6418a2558c5002754feba36fb0
https://doi.org/10.1016/j.isci.2021.103213
https://doi.org/10.1016/j.isci.2021.103213
Autor:
Rose Stewart, Antony Harvey, Oshadi Wimalarathne, Tanya T. Paull, Ji-Hoon Lee, Peter R. Mueller, Seung Woo Ryu, Jon M. Huibregtse, Nicolette A. Ender, D Chase Pectol, Carlos P. Zanini
Publikováno v:
PLoS Biology
PLoS Biology, Vol 18, Iss 7, p e3000606 (2020)
PLoS Biology, Vol 18, Iss 7, p e3000606 (2020)
The 70 kDa heat shock protein (HSP70) family of chaperones are the front line of protection from stress-induced misfolding and aggregation of polypeptides in most organisms and are responsible for promoting the stability, folding, and degradation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb869ce8e21bfbef439eba196b42989
https://doi.org/10.1371/journal.pbio.3000606
https://doi.org/10.1371/journal.pbio.3000606