Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner.

Autor: Jon M Carthy, Farshid S Garmaroudi, Zongshu Luo, Bruce M McManus

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19809 (2011)

Growing evidence suggests the Wnt family of secreted glycoproteins and their associated signaling pathways, linked to development, are recapitulated during wound repair and regeneration events. However, the role of the Wnt pathway in such settings re

Externí odkaz: https://doaj.org/article/5df09038b05649d1acf8442d1795f20c

Versican localizes to the nucleus in proliferating mesenchymal cells

Autor: Bruce M. McManus, Anna Meredith, Jon M. Carthy, Seti Boroomand, Thomas Abraham

Publikováno v: Cardiovascular Pathology. 24:368-374

Objective Versican is a versatile and highly interactive chondroitin sulfate proteoglycan that is found in the extracellular matrix (ECM) of many tissues and is a major component of developing and developed lesions in atherosclerotic vascular disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f104abe50b0228da7aa37327d7c64125
https://doi.org/10.1016/j.carpath.2015.07.010

A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity

Autor: Konstantinos D. Marousis, Christos T. Chasapis, Jon M. Carthy, Detlef Bentrop, Moreno Lelli, Maria Birkou, Vasso Episkopou, Torsten Herrmann, Ariadni K. Loutsidou, Georgios A. Spyroulias

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2017, 429 (15), pp.2373-2386. ⟨10.1016/j.jmb.2017.06.012⟩
Journal of Molecular Biology, 2017, 429 (15), pp.2373-2386. ⟨10.1016/j.jmb.2017.06.012⟩

Arkadia (Rnf111) is an E3 ubiquitin ligase that plays a central role in the amplification of transforming growth factor beta (TGF-β) signaling responses by targeting for degradation the negative regulators of the pathway, Smad6 and Smad7, and the nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdedaf872021f48e5c8495ed7f8638c
https://pubmed.ncbi.nlm.nih.gov/28647409

WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication

Autor: Jon M. Carthy, Bruce M. McManus, Zongshu Luo

Publikováno v: Laboratory Investigation. 92:246-255

Evidence suggests a role for Wnt signaling in vascular wound repair and remodeling events. Despite this, very little is known about the effect of Wnt ligands on the structure and function of vascular cells. In this study, we treated vascular smooth m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c01ca1f0d0206a9b24d69f7dcc83fca
https://doi.org/10.1038/labinvest.2011.164

Minimally invasive imaging method based on second harmonic generation and multiphoton excitation fluorescence in translational respiratory research

Autor: Thomas Abraham, Dmitri V. Pechkovsky, Bruce M. McManus, Samuel J. Wadsworth, Jon M. Carthy

Publikováno v: Respirology. 16:22-33

For translational respiratory research including in the development of clinical diagnostic tools, a minimally invasive imaging method, which can provide both cellular and extracellular structural details with sufficient specificity, sensitivity and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3711baec09f3c4d97718212fc286cb3
https://doi.org/10.1111/j.1440-1843.2010.01898.x