Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jon M. Askham"'
Autor:
Anke Brüning-Richardson, Kelly J Langford, Peter Ruane, Tracy Lee, Jon M Askham, Ewan E Morrison
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28884 (2011)
Most information about the roles of the adenomatous polyposis coli protein (APC) and its binding partner EB1 in mitotic cells has come from siRNA studies. These suggest functions in chromosomal segregation and spindle positioning whose loss might con
Externí odkaz:
https://doaj.org/article/c349b40d2b2d47a6a781a3b479995cb3
Publikováno v:
Aging (Albany NY)
Understanding the molecular mechanisms and biological consequences of genetic changes occurring during bypass of cellular senescence spans a broad area of medical research from the cancer field to regenerative medicine. Senescence escape and immortal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6073ce3c371a7b3a66c6bb69d30127c
http://europepmc.org/articles/PMC2871244
http://europepmc.org/articles/PMC2871244
Autor:
Helmut E. Gabbert, Wendy J Parsons, Kristina Lickvers, Ewan E. Morrison, Heike I. Grabsch, Jon M. Askham, Alfred Boecking, Natalja Pomjanski, Wolfram Mueller
Publikováno v:
The Journal of Pathology. 202:208-214
During mitosis, the spindle checkpoint delays the onset of anaphase until all chromosomes have attached properly to the mitotic spindle, preventing chromosome missegregation. BUB (budding uninhibited by benzimidazole) 1 is one of the key components o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42bd422e98e44be4cfc47adfd8a1d2a6
https://doi.org/10.1002/path.1499
https://doi.org/10.1002/path.1499
Autor:
Luke R. Odell, Adam F. Odell, Monica Hollstein, Jon M. Askham, Hiba Alogheli, Sreenivasan Ponnambalam
Publikováno v:
The Journal of biological chemistry. 288(23)
Exposure to herbal remedies containing the carcinogen aristolochic acid (AA) has been widespread in some regions of the world. Rare A→T TP53 mutations were recently discovered in AA-associated urothelial cancers. The near absence of these mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29ad2bedb412220b1707d5867c0122e
https://pubmed.ncbi.nlm.nih.gov/23612969
https://pubmed.ncbi.nlm.nih.gov/23612969
Autor:
Tracy Lee, Ewan E. Morrison, Peter Ruane, Kelly J. Langford, Jon M. Askham, Anke Brüning-Richardson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 12, p e28884 (2011)
PLoS ONE, Vol 6, Iss 12, p e28884 (2011)
Most information about the roles of the adenomatous polyposis coli protein (APC) and its binding partner EB1 in mitotic cells has come from siRNA studies. These suggest functions in chromosomal segregation and spindle positioning whose loss might con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809317de53f1df5659066060e4926ad1
http://europepmc.org/articles/PMC3244432
http://europepmc.org/articles/PMC3244432
Publikováno v:
Human Molecular Genetics
More than 50% of transitional cell carcinomas of the bladder show loss of heterozygosity of a region spanning the TSC1 locus at 9q34 and mutations of TSC1 have been identified in 14.5% of tumours. These comprise nonsense mutations, splicing mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbb962becdf4a477421e2a2d69353fe
https://pubmed.ncbi.nlm.nih.gov/18397877
https://pubmed.ncbi.nlm.nih.gov/18397877
Publikováno v:
BMC Cell Biology
BMC Cell Biology, Vol 7, Iss 1, p 3 (2006)
BMC Cell Biology, Vol 7, Iss 1, p 3 (2006)
Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular junctions has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4284fca63150075566b761b1f012fa
https://pubmed.ncbi.nlm.nih.gov/16423286
https://pubmed.ncbi.nlm.nih.gov/16423286
Autor:
Heike I, Grabsch, Jon M, Askham, Ewan E, Morrison, Natalja, Pomjanski, Kristina, Lickvers, Wendy J, Parsons, Alfred, Boecking, Helmut E, Gabbert, Wolfram, Mueller
Publikováno v:
The Journal of pathology. 202(2)
During mitosis, the spindle checkpoint delays the onset of anaphase until all chromosomes have attached properly to the mitotic spindle, preventing chromosome missegregation. BUB (budding uninhibited by benzimidazole) 1 is one of the key components o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce28b70353c0ecc9dd3a9bb7f7856df8
https://pubmed.ncbi.nlm.nih.gov/14743503
https://pubmed.ncbi.nlm.nih.gov/14743503
Autor:
Ewan E. Morrison, Jon M. Askham
Publikováno v:
European journal of cell biology. 80(12)
Summary Spindle positioning in animal cells is thought to rely upon the interaction of astral microtubules with the cell cortex. Information on the dynamics of astral microtubules during this process is scarce, in part because of the difficulty in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b225e20a3f0bc55e8d86f54c11c5ee85
https://pubmed.ncbi.nlm.nih.gov/11831388
https://pubmed.ncbi.nlm.nih.gov/11831388
Publikováno v:
Cancer Research. 72:LB-152
Activating p110α mutations are frequently observed in urothelial carcinoma (UC). Their specific effects in urothelial cells and the reason for the large excess of helical domain mutations relative to kinase domain mutations have not been studied. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b87f0c928f95ef22bdc19b3ce2b1e992
https://doi.org/10.1158/1538-7445.am2012-lb-152
https://doi.org/10.1158/1538-7445.am2012-lb-152