Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jon M Kornhauser"'
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
The recent approval of a therapeutic for a circadian disorder has increased interest in developing additional medicines for disorders characterized by circadian disruption. However, previous experience demonstrates that drug development for central n
Externí odkaz:
https://doaj.org/article/79bdf12ee3094b8a94906ead07c217ae
Autor:
Travis J. Wheeler, Peter Hornbeck, Jon M. Kornhauser, Beth L. Murray, Latham, Bin Zhang, Florian Gnad, Nandhikonda, Alexander Nord, Elzbieta Skrzypek
Publikováno v:
Nucleic Acids Research
For 15 years the mission of PhosphoSitePlus® (PSP, https://www.phosphosite.org) has been to provide comprehensive information and tools for the study of mammalian post-translational modifications (PTMs). The number of unique PTMs in PSP is now more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b514388a921d85153f16986dd69854c4
https://pubmed.ncbi.nlm.nih.gov/30445427
https://pubmed.ncbi.nlm.nih.gov/30445427
Autor:
Peter Hornbeck, Jon M. Kornhauser, Elzbieta Skrzypek, Vaughan Latham, Beth L. Murray, Bin Zhang
Publikováno v:
Nucleic Acids Research
PhosphoSitePlus(®) (PSP, http://www.phosphosite.org/), a knowledgebase dedicated to mammalian post-translational modifications (PTMs), contains over 330,000 non-redundant PTMs, including phospho, acetyl, ubiquityl and methyl groups. Over 95% of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9b4186e63e242e2fddd811c3330dee
https://doi.org/10.1093/nar/gku1267
https://doi.org/10.1093/nar/gku1267
Autor:
Bin Zhang, Sasha Tkachev, Vaughan Latham, Jon M. Kornhauser, Beth L. Murray, Peter Hornbeck, Elzbieta Skrzypek, Michael Sullivan
Publikováno v:
Nucleic Acids Research
PhosphoSitePlus (http://www.phosphosite.org) is an open, comprehensive, manually curated and interactive resource for studying experimentally observed post-translational modifications, primarily of human and mouse proteins. It encompasses 1,30,000 no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5d9763fe0764a92cb00ab8db6d4b5b
https://doi.org/10.1093/nar/gkr1122
https://doi.org/10.1093/nar/gkr1122
Autor:
Matthew P. Stokes, Anthony Possemato, Randall K. Wetzel, Jeffrey Mitchell, Michael J. Comb, Julie Nardone, Kimberly Lee, Judit Villén, Joan MacNeill, Roberto D. Polakiewicz, Jon M. Kornhauser, Gregory Innocenti, John Rush, Ailan Guo, Klarisa Rikova, Yi Wang, Steven P. Gygi
Publikováno v:
Proceedings of the National Academy of Sciences. 105:692-697
A major question regarding the sensitivity of solid tumors to targeted kinase inhibitors is why some tumors respond and others do not. The observation that many tumors express EGF receptor (EGFR), yet only a small subset with EGFR-activating mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6085f51aef25b85bb2a1eb36e7b8da74
https://doi.org/10.1073/pnas.0707270105
https://doi.org/10.1073/pnas.0707270105
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 6 (2015)
Frontiers in Pharmacology, Vol 6 (2015)
The recent approval of a therapeutic for a circadian disorder has increased interest in developing additional medicines for disorders characterized by circadian disruption. However, previous experience demonstrates that drug development for central n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960acafe3b2ce9486e14595a1ef7dbc0
Autor:
Adam J. Shaywitz, Eric C. Griffith, Christopher W. Cowan, Linda Hu, Jon M. Kornhauser, Chia A Haddad, Zhengui Xia, Michael E. Greenberg, Ricardo E. Dolmetsch
Publikováno v:
Neuron. 34:221-233
The transcription factor CREB mediates diverse responses in the nervous system. It is not known how CREB induces specific patterns of gene expression in response to different extracellular stimuli. We find that Ca2+ influx into neurons induces CREB p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bea706fc1ab0558bef7582865aa296
https://doi.org/10.1016/s0896-6273(02)00655-4
https://doi.org/10.1016/s0896-6273(02)00655-4
Autor:
Xu Tao, Mari A. Takasu, Wen G. Chen, Jon M. Kornhauser, Ricardo E. Dolmetsch, Matthew B. Dalva, Anne E. West, Adam J. Shaywitz, Michael E. Greenberg
Publikováno v:
Proceedings of the National Academy of Sciences. 98:11024-11031
Plasticity is a remarkable feature of the brain, allowing neuronal structure and function to accommodate to patterns of electrical activity. One component of these long-term changes is the activity-driven induction of new gene expression, which is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516237b0161634cd1f8a562a49c115dc
https://doi.org/10.1073/pnas.191352298
https://doi.org/10.1073/pnas.191352298
Autor:
Yaliang Zhao, Fred W. Turek, Lisa D. Wilsbacher, Martha Hotz Vitaterna, David P. King, Thomas D.L. Steeves, Minoru Tanaka, Joseph S. Takahashi, Marina P. Antoch, Phillip L. Lowrey, Jon M. Kornhauser, Ashvin M. Sangoram
Publikováno v:
Cell. 89:641-653
We used positional cloning to identify the circadian Clock gene in mice. Clock is a large transcription unit with 24 exons spanning approximately 100,000 bp of DNA from which transcript classes of 7.5 and approximately 10 kb arise. Clock encodes a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31415039c5596fddf68778c99faedce5
https://doi.org/10.1016/s0092-8674(00)80245-7
https://doi.org/10.1016/s0092-8674(00)80245-7
Autor:
Sean A. Beausoleil, Vicky Yang, Xiaoying Jia, Jon M. Kornhauser, Jeffrey C. Silva, Kimberly Lee, Jianmin Ren, Jing Zhou, Daniel Mulhern, Mike Aguiar, Hongbo Gu, Vidyasiri Vemulapalli, Mark T. Bedford, Michael J. Comb, Ailan Guo, Yi Wang
Publikováno v:
Molecular & Cellular Proteomics : MCP
Protein methylation is a common posttranslational modification that mostly occurs on arginine and lysine residues. Arginine methylation has been reported to regulate RNA processing, gene transcription, DNA damage repair, protein translocation, and si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a964e3fc2d97938479d6d31a9abf0cfc
https://pubmed.ncbi.nlm.nih.gov/24129315
https://pubmed.ncbi.nlm.nih.gov/24129315