Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Jon M Holy"'
Autor:
Chinnadurai Mani, Grady L. Nelson, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Conor T. Ronayne, Hithardha Palle, Lucas N. Solano, Jon M Holy, Jon N. Rumbley, Venkatram R. Mereddy
Publikováno v:
Biochemical and Biophysical Research Communications. 562:127-132
A novel nitrogen mustard CBISC has been synthesized and evaluated as an anticancer agent. CBISC has been shown to exhibit enhanced cell proliferation inhibition properties against mutant p53 cell lines colorectal cancer WiDr, pancreatic cancer (MIAPa
Publikováno v:
Physical Chemistry Chemical Physics. 23:12692-12705
The majority of in vitro studies of living cells are routinely conducted in a two-dimensional (2D) monolayer culture. Recent studies, however, suggest that 2D cell culture promotes specific types of aberrant cell behaviors due to the growth on non-ph
Publikováno v:
Ultrafast Nonlinear Imaging and Spectroscopy IX.
Cellular metabolism and cell behavior are believed to be significantly different in two-dimensional (2D) cultures from that in vivo. Here, we investigate the environmental effects of the metabolic state of murine breast cancer cells line (4T1) in 2D
Autor:
Anh Cong, Venkatram R. Mereddy, Rafaela M.L. Pimenta, Ahmed A. Heikal, Hong Bok Lee, Jon M Holy
Publikováno v:
Cytometry Part A. 95:80-92
Most studies using intrinsic NAD(P)H as biomarkers for energy metabolism and mitochondrial anomalies have been conducted in routine two-dimensional (2D) cell culture formats. Cellular metabolism and cell behavior, however, can be significantly differ
Autor:
Venkatram R. Mereddy, Jon N. Rumbley, Lucas N. Solano, Shirisha Jonnalagadda, Lester R. Drewes, Grady L. Nelson, Teresa A. Rose-Hellekant, Jon M Holy, Conor T. Ronayne, Sravan K. Jonnalagadda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Novel silyl cyanocinnamic acid derivatives have been synthesized and evaluated as potential anticancer agents. In vitro studies reveal that lead derivatives 2a and 2b have enhanced cancer cell proliferation inhibition properties when compared to the
Autor:
Douglas A. Hicks, Kevin W. Diebel, Lynne T. Bemis, Evan Odean, Juan E. Abrahante, Kun Zhou, Jon M Holy, Brent Schotl, Monique A. Spillman, Andrew J Skildum
Publikováno v:
Oncotarget
// Kun Zhou 1 , Kevin W. Diebel 1 , Jon Holy 1 , Andrew Skildum 1 , Evan Odean 1 , Douglas A. Hicks 2 , Brent Schotl 1 , Juan E. Abrahante 3 , Monique A. Spillman 4 and Lynne T. Bemis 1 1 Department of Biomedical Sciences, University of Minnesota, Du
Autor:
Grady L. Nelson, Erica A. Lueth, Zachary S. Gardner, Skyler L. Hubbard, Shirisha Gurrapu, Lucas N. Solano, Sravan K. Jonnalagadda, Jon M Holy, Tanner J. Schumacher, Conor T. Ronayne, Venkatram R. Mereddy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:776-780
The reaction of carboxylic acids with Baylis-Hillman reaction derived α-bromomethyl acrylic esters readily provide 2-(alkoxycarbonyl)allyl esters in good to excellent yields. These functionalized allyl esters have been evaluated for their cell proli
Autor:
Yaiza Potes, Inês Baldeiras, Ignacio Vega-Naredo, Jenna R. Erickson, Tânia Melo, Silvia Magalhães-Novais, Juan Carlos Bermejo-Millo, Ana Coto-Montes, Katia A. Mesquita, Paulo J. Oliveira, M. Rosário M. Domingues, Jon M Holy, Rute Loureiro, Elisabete Maciel
Publikováno v:
Autophagy. 16(2)
Given the relatively long life of stem cells (SCs), efficient mechanisms of quality control to balance cell survival and resistance to external and internal stress are required. Our objective was to test the relevance of cell quality control mechanis
Autor:
Jon N. Rumbley, Lucas N. Solano, Lester R. Drewes, Venkatram R. Mereddy, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Grady L. Nelson, Jon M Holy, Conor T. Ronayne
Publikováno v:
Oncotarget
Potent and dual monocarboxylate transporter (MCT) 1 and 4 inhibitors have been developed for the first time as potential anticancer agents based on α-cyanocinnamic acid structural template. Candidate inhibitors 1-9 have been evaluated for in vitro c
Autor:
Pavel A. Krasutsky, Amália S. Jurado, Dmytro Krasutsky, Jon M Holy, Teresa L. Serafim, Paulo J. Oliveira, Sergiy Yemets, Filipa Carvalho, Catarina M. Morais
Publikováno v:
Chemico-biological interactions. 296
Triterpenoids have multiple biological properties, although little information is available regarding their toxicity. The present study evaluates the toxicity of two new synthetic lupane derivatives using distinct biological models including syntheti