A Novel Rabbit Model of Retained Hemothorax with Pleural Organization

Autor: Christian J. De Vera, Rebekah L. Emerine, René A. Girard, Krishna Sarva, Jincy Jacob, Ali O. Azghani, Jon M. Florence, Alan Cook, Scott Norwood, Karan P. Singh, Andrey A. Komissarov, Galina Florova, Steven Idell

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 1, p 470 (2023)

Retained hemothorax (RH) is a commonly encountered and potentially severe complication of intrapleural bleeding that can organize with lung restriction. Early surgical intervention and intrapleural fibrinolytic therapy have been advocated. However, t

Externí odkaz: https://doaj.org/article/44d1dc100fbc4ddab00420a72c56f911

Metalloproteinase-9 contributes to endothelial dysfunction in atherosclerosis via protease activated receptor-1.

Autor: Jon M Florence, Agnieszka Krupa, Laela M Booshehri, Timothy C Allen, Anna K Kurdowska

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171427 (2017)

The atherosclerotic process begins when vascular endothelial cells undergo pro-inflammatory changes such as aberrant activation to dysfunctional phenotypes and apoptosis, leading to loss of vascular integrity. Our laboratory has demonstrated that exp

Externí odkaz: https://doaj.org/article/54fbf25a89fa4ee781760eea4322d012

Inhibiting Bruton's tyrosine kinase rescues mice from lethal influenza-induced acute lung injury

Autor: Anna K. Kurdowska, Michael A. Matthay, Agnieszka Krupa, Laela M. Booshehri, Jon M. Florence, Sandra A. Davis

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 315(1)

Infection with seasonal influenza A virus (IAV) leads to lung inflammation and respiratory failure, a main cause of death in influenza-infected patients. Previous experiments in our laboratory indicate that Bruton’s tyrosine kinase (Btk) plays a su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8666e64a30bc96f1eca48077dac87ca3
https://pubmed.ncbi.nlm.nih.gov/29516781

Bruton’s Tyrosine Kinase Mediates FcγRIIa/Toll-Like Receptor–4 Receptor Crosstalk in Human Neutrophils

Autor: Zygmunt Gryczynski, Rafal Luchowski, Theodore J. Standiford, Timothy Craig Allen, Agnieszka Krupa, Jon M. Florence, Rafal Fudala, Marek Fol, Moshiur Rahman, Torry A. Tucker, Ignacy Gryczynski, Anna K. Kurdowska

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 48:240-249

Previous observations by our laboratory indicate that the presence of anti-IL-8 autoantibody:IL-8 immune complexes in lung fluids from patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) comprises an important prognostic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8490d79063b862609a0b6333b310fa4
https://doi.org/10.1165/rcmb.2012-0039oc

Disrupting the Btk Pathway Suppresses COPD-Like Lung Alterations in Atherosclerosis Prone ApoE−/− Mice Following Regular Exposure to Cigarette Smoke

Autor: Agnieszka Krupa, Jon M. Florence, Laela M. Booshehri, Adrian L Gajewski, Anna K. Kurdowska

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 2, p 343 (2018)
International Journal of Molecular Sciences; Volume 19; Issue 2; Pages: 343

Chronic obstructive pulmonary disease (COPD) is associated with severe chronic inflammation that promotes irreversible tissue destruction. Moreover, the most broadly accepted cause of COPD is exposure to cigarette smoke. There is no effective cure an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2c6107decbbdf8b055246240489401
https://doi.org/10.3390/ijms19020343