Výsledky vyhledávání - "Jon L Ruckle"

Akademický článek

First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain

Autor: Patricia A. Walicke, Franz Hefti, Roxanne Bales, Shiao-Ping Lu, Jon L. Ruckle, Mark T. Brown, Christine R. West, David L. Shelton

Publikováno v: PAIN Reports, Vol 3, Iss 3, p e653 (2018)

Abstract. Introduction:. The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. Objectives:. Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerabi

Externí odkaz: https://doaj.org/article/a23e1a0f593f4e798fc68720c1f36903

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Pharmacokinetics and Pharmacodynamics of Anacetrapib Following Single Doses in Healthy, Young Japanese and White Male Subjects

Autor: Jon L. Ruckle, Yang Liu, Rajesh Krishna, Omar F Laterza, Andrew Denker, Josee Cote, Ferdous Gheyas, John A. Wagner

Publikováno v: Journal of clinical pharmacology. 58(2)

Anacetrapib is a cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of mixed dyslipidemia. The aim of the study was to evaluate the pharmacokinetic, pharmacodynamic, and safety characteristics of anacetrapib followi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0a741abc461307177b15b14dfb724b
https://pubmed.ncbi.nlm.nih.gov/28884824

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Phase-0/microdosing studies using PET, AMS, and LC-MS/MS: a range of study methodologies and conduct considerations. Accelerating development of novel pharmaceuticals through safe testing in humans - a practical guide

Autor: Jon L Ruckle, Le T. Vuong, Christy S. John, Tal Burt

Publikováno v: Expert opinion on drug delivery. 14(5)

Phase-0 studies, including microdosing, also called Exploratory Investigational New Drug (eIND) or exploratory clinical trials, are a regulatory framework for first-in-human (FIH) trials. Common to these approaches is the use and implied safety of li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef488635317312e0c3fdcda785352c4f
https://pubmed.ncbi.nlm.nih.gov/27564533

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Safety and Pharmacokinetics of the Anti-Orthopoxvirus Compound ST-246 following a Single Daily Oral Dose for 14 Days in Human Volunteers

Autor: Israel Lichtenstein, Dennis E. Hruby, Thomas Marbury, Shanthakumar R. Tyavanagimatt, Kevin F. Jones, Eric Ross, Jean M. Clarke, Kady M. Honeychurch, Jon L. Ruckle, Jarasvech Chinsangaram, Margaret Pickens, Janet M. Leeds, Denis Mee-Lee, Tove' C. Bolken, Robert Jordan, Michael L. Corrado, Annie M. Frimm

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:4900-4905

ST-246 is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. To this end, a phase 2, double-blind, randomized, placebo-controlled, multicenter trial was conducted to assess the safety, tolerability, and pharmacokinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a1aed11979b20e83e20f7b7f5c3b32
https://doi.org/10.1128/aac.00904-12

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Lycopene bioavailability and metabolism in humans: an accelerator mass spectrometry study

Autor: Karin Wertz, Alexandre Bourgeois, Paul L. Skipper, Myriam Richelle, Rosa G. Liberman, Inge Lise F. Nielsen, Marc Enslen, Steven R. Tannenbaum, Hans-Arno Synal, Gary Williamson, Sunil Kochhar, Tim Schulze-König, Philippe A. Guy, Laurent B. Fay, Jon L. Ruckle, Alastair B. Ross, Robert Rümbeli, Le Thuy Vuong

Publikováno v: The American Journal of Clinical Nutrition. 93:1263-1273

Background To our knowledge, there is no direct information on lycopene metabolism in humans. Objective The objective of this study was to quantify the long-term human bioavailability of lycopene in plasma and skin after a single dose of (14)C-lycope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df629cca1e7cfe9f8ca8925c55e06d1
https://doi.org/10.3945/ajcn.110.008375

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Evaluation of pharmacokinetic parameters and dipeptidyl peptidase-4 inhibition following single doses of sitagliptin in healthy, young Japanese males

Autor: Gary A. Herman, Jon L. Ruckle, Ronald B. Langdon, Amy Qiu Wang, Keith Gottesdiener, Michael J. Davies, Bingming Yi, Goutam C. Mistry, John A. Wagner, Li Chen, Karen Snyder, Patrick Larson, Arthur J. Bergman, Wei Zeng

Publikováno v: British Journal of Clinical Pharmacology. 71:429-436

AIMS Sitagliptin is a selective inhibitor of dipeptidyl peptidase-4 (DPP-4) used to treat type 2 diabetes. The present aim was to evaluate pharmacokinetic (PK), pharmacodynamic (PD) and safety characteristics of sitagliptin following single doses in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42f08666375a5220048a0b3c7fa6d792
https://doi.org/10.1111/j.1365-2125.2010.03852.x

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Contribution of a Heating Element to Topical Anesthesia Patch Efficacy Prior to Vascular Access: Results From Two Randomized, Double-Blind Studies

Autor: Salman Masud, Richard D. Wasnich, Stephen W. Halpern, John C. Campbell, Denis Mee-Lee, Jon L. Ruckle, Michael A. Ashburn, William T. Garland

Publikováno v: Journal of Pain and Symptom Management. 40:510-519

Context Pain associated with superficial procedures, including intravenous (IV) access procedures, should be prevented when possible, especially in children. Objectives To evaluate a topical local anesthetic patch containing lidocaine 70mg/tetracaine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7ba77e62ec0c9f7a5f4e089dc2045c5
https://doi.org/10.1016/j.jpainsymman.2010.01.022

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First-in-human randomized clinical trials of the safety and efficacy of tanezumab for treatment of chronic knee osteoarthritis pain or acute bunionectomy pain

Autor: David L. Shelton, Shiao-Ping Lu, Roxanne Bales, Mark T. Brown, Patricia Ann Walicke, Jon L Ruckle, Franz F. Hefti, Christine R. West

Publikováno v: PAIN Reports, Vol 3, Iss 3, p e653 (2018)

Introduction:. The neurotrophin nerve growth factor has a demonstrated role in pain transduction and pathophysiology. Objectives:. Two randomized, double-blind, placebo-controlled, phase 1 studies were conducted to evaluate safety, tolerability, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704e39a798c8c715d52aeaa0dc85dfe
https://doi.org/10.1097/pr9.0000000000000653

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Safety and Pharmacokinetics of Single Doses of (+)-Calanolide A, a Novel, Naturally Occurring Nonnucleoside Reverse Transcriptase Inhibitor, in Healthy, Human Immunodeficiency Virus-Negative Human Subjects

Autor: Dwain T. Tolbert, David A. Eiznhamer, Bipul Dutta, Jon L. Ruckle, Terri Creagh, Jeremy Giltner, Ze-Qi Xu, Michael T. Flavin

Publikováno v: Antimicrobial Agents and Chemotherapy. 45:1379-1386

(+)-Calanolide A is a novel, naturally occurring, nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase first isolated from a tropical tree (Calophyllum lanigerum) in the Malaysian rain forest. Previous studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7149811ac1ebf40fd608bb254b4b2ed3
https://doi.org/10.1128/aac.45.5.1379-1386.2001

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