Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jon K. Fairweather"'
Publikováno v:
Molecules, Vol 17, Iss 8, Pp 9790-9802 (2012)
A 6-deoxy-a-L-talopyranoside acceptor was readily prepared from methyl a-L-rhamnopyranoside and glycosylated with thiogalactoside donors using NIS/TfOH as the promoter to give good yields of the desired a-linked disaccharide (69–90%). Glycosylation
Externí odkaz:
https://doaj.org/article/e42e954875c146429b36a2f2a17415a4
Autor:
Cai Ping Li, Jon K. Fairweather, Siska Cochran, Ian Bytheway, Vito Ferro, Tomislav Karoli, Ligong Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:344-349
Disaccharide mimetics of a heparin sequence that binds to fibroblast growth factors were prepared by coupling a D-galactose donor with a methyl beta-D-gluco- or xylopyranoside acceptor. When fully sulfated, the glucose or xylose moieties exist in sol
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:699-709
A stepwise synthetic route to the mannooligosaccharides from the neutral fraction of Pichia holstii phosphomannan hydrolysate, including a tetrasaccharylamine component, was developed using only two or three readily available d -mannose building bloc
Autor:
Tomislav Karoli, Ligong Liu, Jon K. Fairweather, R. S. Addison, Cai Ping Li, Edward Hammond, Kicki Bergefall, Edward Trybala, Vito Ferro, Siska Cochran
Publikováno v:
Journal of Medicinal Chemistry. 48:8229-8236
The phosphosulfomannan 1 (PI-88) is a mixture of highly sulfated oligosaccharides that is currently undergoing clinical evaluation in cancer patients. As well as its anticancer properties, 1 displays a number of other interesting biological activitie
Publikováno v:
Glycobiology. 14:775-781
A simple and sensitive method for the characterization of products synthesized in vitro by polysaccharide synthases is described. It relies on the use of 1 3 C-enriched nucleotide sugars as substrates and on the analysis of the newly synthesized poly
Publikováno v:
ChemBioChem. 3:866-873
Bacillus 1,3-1,4-beta-glucanases hydrolyze 1,3-1,4-beta-gluco-oligosaccharides with a retaining mechanism. The binding-site cleft of these endoglycosidases is composed of six subsites (-4 to +2) of which subsite -3 makes the largest contribution to t
Publikováno v:
Chemistry - A European Journal. 7:4651-4655
Glycosynthases are engineered glycosidases which are hydrolytically inactive yet efficiently catalyse transglycosylation reactions of glycosyl fluoride donors, and are thus promising tools for the enzymatic synthesis of oligosaccharides. Two endo-gly
Publikováno v:
Tetrahedron. 55:3695-3706
An endoglucanase from Humicola insolens has been used to glycosylate a range of alkenyl β- d -C- glucopyranosides with β-lactosyl fluoride. The resulting trisaccharides have been subjected to the action of a commercial β-galactosidase to form alke
Publikováno v:
Molecules
Molecules; Volume 17; Issue 8; Pages: 9790-9802
Molecules, Vol 17, Iss 8, Pp 9790-9802 (2012)
Molecules; Volume 17; Issue 8; Pages: 9790-9802
Molecules, Vol 17, Iss 8, Pp 9790-9802 (2012)
A 6-deoxy-a-L-talopyranoside acceptor was readily prepared from methyl a-L-rhamnopyranoside and glycosylated with thiogalactoside donors using NIS/TfOH as the promoter to give good yields of the desired a-linked disaccharide (69–90%). Glycosylation
Publikováno v:
ChemInform. 33
Glycosynthases are engineered glycosidases which are hydrolytically inactive yet efficiently catalyse transglycosylation reactions of glycosyl fluoride donors, and are thus promising tools for the enzymatic synthesis of oligosaccharides. Two endo-gly