Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jon Hilden"'
Publikováno v:
Journal of Pharmaceutical Sciences. 111:710-716
The increase in solid fraction (SF) of a packed granule bed with pressure applied during the in-die compression process results in an evolution of the tablet's matrix and mechanical strength. In this case study, the tensile strength (TS) of a dry gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa25f236a5159157465de9e474794be
https://doi.org/10.1016/j.xphs.2021.09.033
https://doi.org/10.1016/j.xphs.2021.09.033
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c260fddd98f2ee2abcaa44b6ef6c7dd2
https://doi.org/10.1002/0471266949.bmc263
https://doi.org/10.1002/0471266949.bmc263
Autor:
Jon Hilden, Timothy T. Kramer, John Strong, Ilgaz Akseli, Chen Mao, Jeffrey M. Katz, Frederick Osei-Yeboah, Ron C. Kelly
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1081-1084
The bulk properties of a powder are dependent on the preparation, treatment, and storage of the sample, that is, how it was handled. The particles can be packed to have a range of bulk densities and, moreover, the slightest disturbance of the powder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4ad595e38ec36978ee02c5cb014663
https://doi.org/10.1016/j.xphs.2018.10.009
https://doi.org/10.1016/j.xphs.2018.10.009
Publikováno v:
Journal of Pharmaceutical Sciences. 108:485-493
The modern rotary pharmaceutical tablet press is capable of accepting or rejecting individual tablets based on the measured compression force of the tablet. Because during steady operation, each tablet is compressed to the same thickness, a larger co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3cd9b6ac7a8688882845186001d785
https://doi.org/10.1016/j.xphs.2018.07.004
https://doi.org/10.1016/j.xphs.2018.07.004
Publikováno v:
Powder Technology. 338:44-54
The blending of powders is a critical step in pharmaceutical drug product manufacturing as it ensures that each dosage unit will contain the same intended fraction of active pharmaceutical ingredient (API). Under-blending thus poses a significant ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb7d052cd096b0bc0f937c6b61633232
https://doi.org/10.1016/j.powtec.2018.06.004
https://doi.org/10.1016/j.powtec.2018.06.004
Publikováno v:
Powder Technology. 315:410-421
The objective of this work is to measure the adhesive force profile between a punch face and powder compact in-die during the decompression phase of a tablet compaction process. An instrumented punch was developed for use on a single station compacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d495d03aedf88a43c4483ea2f4b65a9
https://doi.org/10.1016/j.powtec.2017.04.003
https://doi.org/10.1016/j.powtec.2017.04.003
Publikováno v:
Journal of Pharmaceutical Sciences. 106:418-421
The diametrical compression (DC) test, as defined in United States Pharmacopeia1217and in American Society for Testing and Materials testing standard D 3967, has been used extensively to derive the tensile strength (TS) of pharmaceutical tablets from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506e55c9b27ec8dca9345f0b6a66bc2b
https://doi.org/10.1016/j.xphs.2016.08.004
https://doi.org/10.1016/j.xphs.2016.08.004
Autor:
Mark Schrad, Tim Pletcher, Trent Sommer, Jessica Reynolds, Carl Hartmann, Jon Hilden, Aaron Zettler
Publikováno v:
Powder Technology. 305:723-738
In recent years, more and more powder blending operations have been augmented with the addition of an intensifier bar (I-bar) in a tumble bin. While the tumble bin rotates with rotational speeds of 5–20 rpm, I-bars rotate at 1000–4000 rpm, with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d78b3c7f5e02bb8e2d37ef48097fc7
https://doi.org/10.1016/j.powtec.2016.09.064
https://doi.org/10.1016/j.powtec.2016.09.064
Autor:
Jon Hilden, Zhenqi Shi
Publikováno v:
Journal of Pharmaceutical Innovation. 12:41-48
Roller compaction is commonly used in the pharmaceutical industry to improve powder flow and compositional uniformity. The process produces ribbons which are milled into granules. The ribbon solid fraction (SF) can affect both the granule size and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcf2e810d49be912568f107d77a30a68
https://doi.org/10.1007/s12247-016-9267-4
https://doi.org/10.1007/s12247-016-9267-4
Autor:
Phenil J. Patel, Christopher Breslin, Michael Koenig, Aaron Zettler, Jon Hilden, Aktham Aburub, Allgeier Matthew Carl, Biplob Mitra
Publikováno v:
Journal of Pharmaceutical Innovation. 11:189-199
In pharmaceutical development, powder flow characteristics are notoriously difficult to predict. Although tests exist that aim to determine the flowability of powders, many have not been definitively correlated with a powder’s performance in downst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e0ccf02a2d2e9705af688c4cb9b0438
https://doi.org/10.1007/s12247-016-9258-5
https://doi.org/10.1007/s12247-016-9258-5