Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jon Goldhill"'
Publikováno v:
British Journal of Pharmacology. 133:1346-1354
This in vitro study was designed to determine the potential use of the NK1 antagonist, SR140333 as an anti-diarrhoeal treatment for food allergy or inflammatory bowel disease. The effect of various immune and neuronal stimuli on human colonic substan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66fa934b421a9afb88f4bdddc1b4b6bc
https://doi.org/10.1038/sj.bjp.0704194
https://doi.org/10.1038/sj.bjp.0704194
Publikováno v:
Journal of Pharmacy and Pharmacology. 51:1041-1048
Existing models used to study the mechanism of action and antagonism of tachykinergic effects on intestinal contraction and secretion suffer from technical problems and have not been fully characterized using specific tachykinin antagonists. Contract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06aba6b7dacb2fd8244a59f9b565f1d4
https://doi.org/10.1211/0022357991773375
https://doi.org/10.1211/0022357991773375
Autor:
Iztchak Angel, Jon Goldhill
Publikováno v:
European Journal of Pharmacology. 363:161-168
The guinea pig colon was used to elucidate the mechanism of tachykinin-induced secretion. Increased short-circuit current was observed in response to natural and synthetic tachykinins with rank orders of potency of substance P > neurokinin A = neurop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd90c2c2f7bf67fa24034e3db20b1f9
https://doi.org/10.1016/s0014-2999(98)00797-3
https://doi.org/10.1016/s0014-2999(98)00797-3
Publikováno v:
European Journal of Pharmacology. 353:289-296
The present study characterized the rat colonic secretory response to 5-hydroxytryptamine (5-HT) and determined alterations in this response following stress. 5-HT stimulated rat colonic short-circuit current in a concentration-dependent fashion (pD2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a749e0b701f6ab96888826916cc4e1c
https://doi.org/10.1016/s0014-2999(98)00420-8
https://doi.org/10.1016/s0014-2999(98)00420-8
Publikováno v:
Journal of Pharmacy and Pharmacology. 48:651-656
One side-effect of the therapeutic use of antimicrobial agents is respiratory paralysis as a result of inhibition of skeletal neuromuscular transmission; cholinergic neuro-effector motor transmission in the gastrointestinal tract is inhibited by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af97aab86636374f8439e8d97c536ba2
https://doi.org/10.1111/j.2042-7158.1996.tb05990.x
https://doi.org/10.1111/j.2042-7158.1996.tb05990.x
Autor:
Jon Goldhill, W. H. Percy
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 265:G1064-G1070
A novel in vitro technique capable of simultaneously measuring distal colonic epithelial potential difference and muscle contraction is described. Under basal conditions, oscillations in both muscle tone and potential difference were observed. Pelvic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e5c861ae051b1b7c8e80ba3b41a325
https://doi.org/10.1152/ajpgi.1993.265.6.g1064
https://doi.org/10.1152/ajpgi.1993.265.6.g1064
Publikováno v:
Journal of Pharmacy and Pharmacology. 45:210-214
The ability of loperamide to influence intestinal fluid transport was assessed using a dual loop preparation. Loperamide was applied to the lumen of the oral, but not the aboral loop, yet basal and prostaglandin-stimulated fluid transport was affecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b5cf7c60fe5d07830ee4358713ce75
https://doi.org/10.1111/j.2042-7158.1993.tb05534.x
https://doi.org/10.1111/j.2042-7158.1993.tb05534.x
Publikováno v:
Journal of Pharmacy and Pharmacology. 45:919-921
Mucosal loperamide inhibited the absorption of glycine by everted sacs of rat small intestine over 10-, 30- or 60-min incubation periods, but loperamide oxide was without effect. In stripped intestinal sheets, loperamide inhibited the rise in short-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128fb9579b3fd21cd4a275e3c238e362
https://doi.org/10.1111/j.2042-7158.1993.tb05622.x
https://doi.org/10.1111/j.2042-7158.1993.tb05622.x
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
The potent neurokinin receptor 1 (NK1) antagonist SR-140333 has previously been shown to reduce castor oil-induced secretion in animal models. The importance of tachykinins in neuroimmune control of secretion and the effect of SR-140333 on key points
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062206ef2acde712da279d7177bace6f
https://pubmed.ncbi.nlm.nih.gov/11245602
https://pubmed.ncbi.nlm.nih.gov/11245602
Publikováno v:
European journal of pharmacology. 323(2-3)
Interaction between the 5-HT 4 receptor and cholinergic-dependent and -independent contraction of the rat oesophageal muscularis mucosae was determined. Substance P- (in the presence of atropine) and carbachol-precontracted tissue was relaxed by tryp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb607729e24c5ae9afbaf5a9b5daaa3
https://pubmed.ncbi.nlm.nih.gov/9128843
https://pubmed.ncbi.nlm.nih.gov/9128843