Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jon Goerke"'
Publikováno v:
Pediatric Research. 58:206-210
Hyaluronan (HA), an ionic polymer, is normally present in the alveolar subphase and is known to decrease lung surfactant inactivation caused by serum in vitro. In this study, we examined whether HA can ameliorate the inactivating effects of meconium
Publikováno v:
Pediatric Research. 57:237-241
Hyaluronan (HA) is an anionic polymer and a constituent of alveolar fluid that can bind proteins, phospholipids, and water. Previous studies have established that nonionic polymers improve the surface activity of pulmonary surfactants by decreasing i
Autor:
Jon Goerke, Cynthia Brown, Lennell Allen, Amber Stumbaugh, Howard Clark, Francis R Poulain, Samuel Hawgood, Jess Edmondson
Publikováno v:
Journal of Virology. 78:8565-8572
Collectins are secreted collagen-like lectins that bind, agglutinate, and neutralize influenza A virus (IAV) in vitro. Surfactant proteins A and D (SP-A and SP-D) are collectins expressed in the airway and alveolar epithelium and could have a role in
Autor:
Leland G. Dobbs, Robert Ertsey, Cheryl J. Chapin, Louis M. Scavo, Jeff N. Vanderbilt, Joseph A. Kitterman, Nicolas F M Porta, Jon Goerke
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 282:L431-L439
Oligohydramnios (OH) retards fetal lung growth by producing less lung distension than normal. To examine effects of decreased distension on fetal lung development, we produced OH in rats by puncture of uterus and fetal membranes at 16 days of gestati
Publikováno v:
Journal of Applied Physiology. 91:2024-2034
Nitrogen dioxide (NO2) is a ubiquitous, pollutant gas that produces a broad range of pathological and physiological effects on the lung. Absorption of inhaled NO2 is coupled to near-interfacial reactions between the solute gas and constituents of the
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 164:1531-1536
Addition of nonionic polymers such as polyethylene glycol (PEG) and dextran ameliorates inactivation of Survanta by a variety of substances in vitro. Addition of polymers to Survanta also improves pulmonary function when used to treat rats with lung
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 162:623-628
Substances (for example, serum proteins or meconium) that interfere with the activity of pulmonary surfactant in vitro may also be important in the pathogenesis or progression of acute lung injury. Addition of polymers such as dextran or polyethylene
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 159:1391-1395
A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases. To find whether i