Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jon G. Sundelof"'
Autor:
Frank P. DiNinno, Gregory P. Rouen, Jon G. Sundelof, Joanne B. Laub, Mark L. Greenlee, Joann Huber, Gail G. Hammond, Milton L. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3225-3230
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32811c5ac5a3f04df24eaa1c565a4afa
https://doi.org/10.1016/s0960-894x(99)00567-3
https://doi.org/10.1016/s0960-894x(99)00567-3
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2973-2976
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0cba274765990296a6392c59ca6997
https://doi.org/10.1016/s0960-894x(99)00526-0
https://doi.org/10.1016/s0960-894x(99)00526-0
Autor:
James V. Heck, John W. Kozarich, Lynn L. Silver, Joyce Kohler, R Thompson, Charles Gill, Frank P. DiNinno, Joann Huber, Hugh Rosen, Robert R. Wilkening, Jeffrey H. Epstein-Toney, Jon G. Sundelof, Barbara A. Pelak, Karen Dorso, Richard Hajdu, Gail G. Hammond, Kenneth J. Wildonger, Helmut Kropp, Timothy A. Blizzard, Jesse J. Jackson, Ronald W. Ratcliffe, Milton L. Hammond, George R. Lankas
Publikováno v:
Science. 283:703-706
A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial resistance was also the structural basis for ameliorating immunopathology. Expuls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec914fb7884fd84749274c4d2abcccc
https://doi.org/10.1126/science.283.5402.703
https://doi.org/10.1126/science.283.5402.703
Publikováno v:
Antimicrobial Agents and Chemotherapy. 41:1743-1748
L-749,345 is a carbapenem antibiotic, currently in phase II clinical trials, which possesses a broad antibacterial spectrum and extended half-life. The time courses of levels of the drugs in plasma and urinary recovery were evaluated for L-749,345, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50281cb035ecf4734d6c3ebe067a09c4
https://doi.org/10.1128/aac.41.8.1743
https://doi.org/10.1128/aac.41.8.1743
Autor:
Jon G. Sundelof, Earl St. Rose, Kenneth J. Wildonger, Karen Dorso, Timothy A. Blizzard, Sandra P. Szumiloski, Ronald W. Ratcliffe, Sherman T. Waddell, Joyce Kohler, Joann Huber, Robert R. Wilkening, Gail G. Hammond
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1427-1432
A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e7c77a7ce92529b58445a9083e9a7f
https://doi.org/10.1016/0960-894x(95)00235-l
https://doi.org/10.1016/0960-894x(95)00235-l
Autor:
Sandra P. Szumiloski, Gail G. Hammond, Joyce Kohler, Earl St. Rose, Kenneth J. Wildonger, Timothy A. Blizzard, Sherman T. Waddell, Robert R. Wilkening, Jon G. Sundelof, Karen Dorso, Joann Huber, Ronald W. Ratcliffe
Publikováno v:
ChemInform. 26
A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a4837781399af25e1733bfc5e98571
https://doi.org/10.1002/chin.199544260
https://doi.org/10.1002/chin.199544260
Autor:
Frank P. DiNinno, Joann Huber, Jon G. Sundelof, Milton L. Hammond, Gail G. Hammond, Mark L. Greenlee, Joanne B. Laub, Gregory P. Rouen
Publikováno v:
ChemInform. 31
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf205825e25b28594030ec37e68736b
https://doi.org/10.1002/chin.200008261
https://doi.org/10.1002/chin.200008261
Publikováno v:
ChemInform. 31
A series of amidinium-substituted 2-dibenzofuranylcarbapenems with potent activity against MRSA has been synthesized via a Stille cross-coupling reaction. These new carbapenems show reduced serum protein binding and improved in vivo efficacy as a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e648f76be2cd1404a5e646db8f4f950f
https://doi.org/10.1002/chin.200007212
https://doi.org/10.1002/chin.200007212
Autor:
Gail G. Hammond, J.V. Heck, Dann L. Parker, Timothy A. Blizzard, Kenneth J. Wildonger, Jon G. Sundelof, Walter J. May, Ronald W. Ratcliffe, Sherman T. Waddell, Robert R. Wilkening, Milton L. Hammond, Joanne Huber, Karen Dorso, Gina M. Santorelli, Joyce Kohler, E. St. Rose, Jerry D. Morgan
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
A series of 1beta-methyl-2-(naphthosultamyl)methyl-carbapenems bearing dicationic groups on the naphthosultamyl moiety was prepared and evaluated for activity against resistant gram-positive bacteria. Based on a combination of excellent in vitro anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9353b784213659ca2ff75dda56845d1
https://pubmed.ncbi.nlm.nih.gov/10201828
https://pubmed.ncbi.nlm.nih.gov/10201828
Autor:
R Thompson, Charles Gill, Lynn S. Gerckens, Hugh Rosen, Jon G. Sundelof, Helmut Kropp, Jesse J. Jackson, Barbara A. Pelak
Publikováno v:
Antimicrobial agents and chemotherapy. 42(8)
MK-826 (formerly L-749,345), is a potent 1-β-methyl carbapenem with a long half-life and broad spectrum of activity. This compound is presently in phase-II clinical trials. Its activity against a number of gram-positive and gram-negative organisms w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1bef6103f17a74d243bb8d2284f4a4
https://pubmed.ncbi.nlm.nih.gov/9687396
https://pubmed.ncbi.nlm.nih.gov/9687396