Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jon G. Selbo"'
Autor:
Steve P. Wene, Jon G. Selbo, Robert J. Mourey, Lesley A. Albin, Po-Chang Chiang, J. Scott Daniels, Sarah A. South, David R. Anderson
Publikováno v:
Journal of Pharmaceutical Sciences. 98:248-256
A potent pyridine-containing MK2 inhibitor has recently been internally discovered. In pre-clinical dosing, the low solubility of the neutral form limited oral bioavailability and dose escalation in toxicity studies. A mesylate salt was developed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd0cfaa94b6d9838c3229faef62b376
https://doi.org/10.1002/jps.21425
https://doi.org/10.1002/jps.21425
Autor:
Na Li, Liangbiao George Hu, Jon G. Selbo, Yiding Hu, Timothy G. Brayman, Kimberly M. Shevlin, Po-Chang Chiang, Jason D. Blom, Yurong Lai
Publikováno v:
Nanoscale Research Letters
Nanoscale Research Letters, Vol 3, Iss 9, Pp 321-329 (2008)
Nanoscale Research Letters, Vol 3, Iss 9, Pp 321-329 (2008)
In present study, the potential drug delivery of nanoformulations was validated via the comparison of cellular uptake of nanoparticles in various cell lines and in vivo pulmonary cellular uptake in intratracheally (IT) dosed rat model. Nanoparticles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1e5505bf77a6bbd5ee94cbbce15185
http://europepmc.org/articles/PMC3244889
http://europepmc.org/articles/PMC3244889
Autor:
Steven L. Roberds, Steve P. Wene, Mark E. Smith, Chad J. Warren, Shuxia Zhou, Denise K. Pretzer, Jan L. Wahlstrom, Jon G. Selbo, Po-Chang Chiang, Sarbani Ghosh, L. Lena Zhang, Lesley A. Albin
Publikováno v:
Journal of Experimental Nanoscience. 2:239-250
Aqueous insolubility is recognized throughout the pharmaceutical industry as a major hurdle for pre-clinical and clinical drug delivery. Pre-clinical, early efficacy, and proof of concept studies oftentimes rely on model compounds that have less than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f38ef66e1371ae21d0841d7a053646fa
https://doi.org/10.1080/17458080601134540
https://doi.org/10.1080/17458080601134540
Autor:
Steven L. Roberds, Jon G. Selbo, Jan L. Wahlstrom, Hideji Fujiwara, Sarbani Ghosh, Po-Chang Chiang
Publikováno v:
Basicclinical pharmacologytoxicology. 102(5)
Cytochrome P450-derived epoxyeicosatrienoic acids (EET) are biologically active metabolites of arachidonic acid that have potent effects on renal vascular reactivity and tubular ion transport and have been implicated in the control of blood pressure.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25dbf578f1afdb7802fce2e8053bff9
https://pubmed.ncbi.nlm.nih.gov/18312493
https://pubmed.ncbi.nlm.nih.gov/18312493
Publikováno v:
Journal of Inclusion Phenomena & Macrocyclic Chemistry; Feb2003, Vol. 45 Issue 1/2, p73-78, 6p