Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Jon G, Mabley"'
Publikováno v:
Cardiovascular Toxicology. 17:393-404
Highly active anti-retroviral therapy has proved successful in reducing morbidity and mortality associated with HIV infection though it has been linked to increased risk of cardiovascular disease. To date, the direct effects of the anti-retroviral dr
Publikováno v:
Thrombosis research. 176
Autor:
Paul R. Gard, Mark Yeoman, Jon G. Mabley, Marcus Allen, Tina Ghela, Bhavik Anil Patel, Stephen Robinson, Talia Walter, Prabal K. Chatterjee, Jonathan Golding, Rachel Morris, Sara Fidalgo, Lucy B. Diss, Rosemary Tucker, Sarah Dyball, Paul Young
Publikováno v:
Autonomic Neuroscience. 195:8-15
Paraquat, a common herbicide, is responsible for large numbers of deaths worldwide through both deliberate and accidental ingestion. Previous studies have eluded that the bioavailability of paraquat increases substantially with increasing dose and th
Publikováno v:
British Journal of Pharmacology. 169:1153-1165
Background and Purpose Oestrogens can interact directly with membrane receptors and channels and can activate vascular BKCa channels. We hypothesized that novel oestrogen derivatives could relax smooth muscle by an extracllular effect on the α and
Autor:
Pal Pacher, Kanneganti G.K. Murthy, Csaba Szabó, Garry J. Southan, Jon G. Mabley, Andrew L. Salzman, William Williams
Publikováno v:
Shock. 32:258-262
Endogenous purines, including inosine, have been shown to exert immunomodulatory and anti-inflammatory effects in a variety of disease models. The dosage of inosine required for these effects has been shown to be between 200 and 600 mg kg(-1) because
Publikováno v:
Molecular Medicine. 15:166-172
Exposure to ricin, either by accident through ingestion of castor oil plant seeds or intentionally through its use as a bioweapon, invariably leads to multiple organ damage and death. Currently there is only a vaccine in advanced development to ricin
Autor:
Sandor Batkai, Vivek Patel, Mohanraj Rajesh, Bani Mukhopadhyay, Pal Pacher, Lucas Liaudet, Jon G. Mabley, György Haskó, Csaba Szabó, Partha Mukhopadhyay
Publikováno v:
Journal of Cellular and Molecular Medicine
In this study, we investigated the effect of the xanthine oxidase (XO) inhibitor, allopurinol (ALP), on cardiac dysfunction, oxidative-nitrosative stress, apoptosis, poly(ADP-ribose) polymerase (PARP) activity and fibrosis associated with diabetic ca
Autor:
Csaba Szabó, Jon G. Mabley
Publikováno v:
Future Rheumatology. 3:169-181
Environmental factors have long been suspected to affect the pathogenesis and incidence of inflammatory diseases. Epidemiological research has demonstrated that sunlight, or rather ultraviolet radiation exposure, is one such environmental factor that
Autor:
David Bleich, Csaba Szabó, Zoltán Németh, György Haskó, Jon G. Mabley, Bruce N. Cronstein, Leonóra Himer, Balázs Csóka, E. Sylvester Vizi, Edwin A. Deitch, Pal Pacher
Publikováno v:
The FASEB Journal. 21:2379-2388
Growing evidence indicates that adenosine receptors could be promising therapeutic targets in autoimmune diseases. Here we studied the role of adenosine receptors in controlling the course of type 1 diabetes. Diabetes in CD-1 mice was induced by mult
Autor:
and Andrew L. Salzman, John H. Van Duzer, Hongshan Li, Jing Zhou, Prakash Jagtap, Erkan Baloglu, Garry J. Southan, Jon G. Mabley, Csaba Szabó
Publikováno v:
Journal of Medicinal Chemistry. 48:5100-5103
Novel indeno[1,2-c]isoquinolinone derivatives were synthesized and evaluated as inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1). These potent nonmutagenic PARP-1 inhibitors possess an additional five-membered ring between the