Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jon E, Peterson"'
Publikováno v:
Bioanalysis. 13:787-796
Biomarker assay method development is a multistep rigorous process and calibrant material selection is integral to ensuring the quality of such assays. However, the impact of selection of calibrator material may often get overlooked. In this article,
Autor:
Camelia Chiriac, Zheng Ouyang, Linna Wang, Jia Duo, Jon E. Peterson, Donata David-brown, Qin C Ji, Alexander T. Kozhich, Gerard Dalglish
Publikováno v:
SLAS technology. 25(5)
Acoustic liquid handlers deliver small volumes (nL-µL) of multiple fluid types with accuracy and dynamic viscosity profiling. They are widely used in the pharmaceutical industry with applications extending from high-throughput screening in compound
Autor:
Binodh DeSilva, Alexander T. Kozhich, Rong Liu, Jia Duo, Jon E. Peterson, Jonathan Haulenbeek, Donata David-brown, Lora Hamuro, Linlin Luo, Renuka Pillutla, Steven P. Piccoli, Rasa Santockyte, JoAnne Bruno, Yan J Zhang, Suk Kwok
Publikováno v:
Bioanalysis. 10:559-576
Ligand-binding assay (LBA) performance depends on quality reagents. Strategic reagent screening and characterization is critical to LBA development, optimization and validation. Application of advanced technologies expedites the reagent screening and
Autor:
Jim X Shen, Yue Zhao, Jon E. Peterson, Philip Joyce, Barry R Jones, Guowen Liu, Jane Liu, David Marchisin, Suk Kwok
Publikováno v:
Bioanalysis. 10:23-33
Aim: Recombinant FGF21 analogs are under wide ranging investigations as a potential therapeutic agent for Type 2 diabetes, as well as other metabolic disorders. The endogenous FGF21 is often used as a surrogate pharmacodynamic(PD) biomarker to assess
Autor:
Jon E. Peterson, Daoyu Duan, Yan G. Ni, Connie Wang, Chad Ray, John Allinson, Martha Hokom, Sara Hamon, Joel A Mathews, Xuemei Zhao, Greta Wegner
Publikováno v:
The AAPS Journal. 22
Blood-based soluble protein biomarkers provide invaluable clinical information about patients and are used as diagnostic, prognostic, and pharmacodynamic markers. The most commonly used blood sample matrices are serum and different types of plasma. I
Autor:
Jennifer Postelnek, Carol Gleason, Jon E. Peterson, Robert Neely, Steven P. Piccoli, Michael Robbins
Publikováno v:
The AAPS Journal. 18:989-999
Elotuzumab is a first in class humanized IgG1 monoclonal antibody for the treatment of multiple myeloma (MM). Elotuzumab targets the glycoprotein signaling lymphocyte activation molecule family 7 (SLAMF7, also described as CS1 or CRACC) which is expr
Publikováno v:
Analytical chemistry. 89(9)
With the development of modern instrumentation and technologies, mass spectrometry based assays have played an important role in protein bioanalysis. We have developed a novel strategy by combining the "bottom-up" and "top-down" approaches using both
Autor:
Emile Pitre, Catharine Hoffman Beyer, Nevena Lalic, Paul D. Sampson, Jon E. Peterson, Brian J. Buchwitz, Barbara T. Wakimoto
Publikováno v:
CBE Life Sciences Education
Undergraduates entering science curricula differ greatly in individual starting points and learning needs. The fast pace, high enrollment, and high stakes of introductory science courses, however, limit students’ opportunities to self-assess and mo
Autor:
Oenick Marsha Denise Bale, Susan L. Connors, Jon E. Peterson, Lea Vacca Michel, David Zurakowski, Giannoula Klement, Judah Folkman, Joseph E. Italiano, Robert J. D'Amato
Publikováno v:
Angiogenesis. 15:265-273
Platelets sequester angiogenesis regulatory proteins which suggests an avenue for developing biomarkers to monitor disease. We describe a comparison of angiogenesis regulatory proteins found in platelets of colorectal cancer patients and normal contr
Autor:
Joseph E. Italiano, Judah Folkman, Tai-Tung Yip, Abdo Abou-Slaybi, Nandita Bhattacharya, Nava Almog, George N. Naumov, Elise Bender, Jon E. Peterson, Vladimir N. Podust, Giannoula Klement, David Cervi
Publikováno v:
Blood. 111:1201-1207
Early tumor detection and intervention are important determinants of survival in patients with cancer. We have recently reported that the “platelet angiogenesis proteome” may be used to detect microscopic tumors in mice. We now present evidence t