Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Jon D. Robertus"'
Publikováno v:
Toxins, Vol 3, Iss 10, Pp 1233-1248 (2011)
Ricin is a potent cytotoxin easily purified in large quantities. It presents a significant public health concern due to its potential use as a bioterrorism agent. For this reason, extensive efforts have been underway to develop antidotes against this
Externí odkaz:
https://doaj.org/article/5f9e710e7cc543e88be0b89c7a42d2af
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 4, Iss 1, p 26 (2008)
Oxazolo[5,4-d]pyrimidines can be considered as 9-oxa-purine analogs of naturally occurring nucleic acid bases. Interest in this ring system has increased due to recent reports of biologically active derivatives. In particular, 5-aminooxazolo[5,4-d]py
Externí odkaz:
https://doaj.org/article/086eb1ff45314d85a7c8562e522b331b
Autor:
Jon D. Robertus, Kristen Procko, S. Reid Long, Eman Ghanem, Keith J. Stevenson, Bradley J. Holliday, Lauren J. DePue, Stacia E. Rodenbusch, Stephen F. Martin, Eric V. Anslyn, Richard A. Jones, Ruth I. Shear, Josh T. Beckham, Sarah L. Simmons
Publikováno v:
Journal of Chemical Education. 95:248-258
Innovative models of teaching through research have broken the long-held paradigm that core chemistry competencies must be taught with predictable, scripted experiments. We describe here five fundamentally different, course-based undergraduate resear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc152b115ef49fabb88a5e1bac06bf01
https://doi.org/10.1021/acs.jchemed.7b00294
https://doi.org/10.1021/acs.jchemed.7b00294
Autor:
Devinder Ubhi, Jon D. Robertus
Publikováno v:
Journal of Molecular Biology. 427(4):901-909
The cobalamin-independent methionine synthase enzyme catalyzes a challenging reaction: the direct transfer of a methyl from 5-methyl-tetrahydrofolate-glutamate3 to the l -homocysteine thiol. The enzyme has a dual (βα)8 TIM barrel structure that bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb6f4c09b41eeb5b42968b5f134c858d
Publikováno v:
Journal of Molecular Biology. 426:1839-1847
The cobalamin-independent methionine synthase from Candida albicans, known as Met6p, is a 90-kDa enzyme that consists of two (βα)8 barrels. The active site is located between the two domains and has binding sites for a zinc ion and substrates L-hom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a2341772f63fba623755db7eddffcc
https://doi.org/10.1016/j.jmb.2014.02.006
https://doi.org/10.1016/j.jmb.2014.02.006
Autor:
Grace Kago, Jon D. Robertus, Ramakrishna Edupuganti, Robert M. Krug, Eric V. Anslyn, Sanmitra Barman, Ran Chen, Lei You, Vlad Codrea
Publikováno v:
European Journal of Medicinal Chemistry. 71:81-90
A library of hydrazide derivatives was synthesized to target non-structural protein 1 of influenza A virus (NS1) as a means to develop anti-influenza drug leads. The lead compound 3-hydroxy-N-[(Z)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylideneamino]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d56cf7bea1c206c2f999babcdd8b9b3
https://doi.org/10.1016/j.ejmech.2013.10.063
https://doi.org/10.1016/j.ejmech.2013.10.063
Autor:
Lawrence A. Manzano, Paul A. Wiget, Eric V. Anslyn, Ryota Saito, Jeff M. Pruet, Jon D. Robertus, Arthur F. Monzingo, Ishan Kamat, Karl R. Jasheway
Publikováno v:
Journal of Medicinal Chemistry. 56:320-329
Several 7-peptide-substituted pterins were synthesized and tested as competitive active-site inhibitors of ricin toxin A (RTA). Focus began on dipeptide conjugates, and these results further guided the construction of several tripeptide conjugates. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22534c162a007d9aa089694017f86efd
https://doi.org/10.1021/jm3016393
https://doi.org/10.1021/jm3016393
Publikováno v:
Toxins, Vol 3, Iss 10, Pp 1233-1248 (2011)
Toxins
Toxins
Ricin is a potent cytotoxin easily purified in large quantities. It presents a significant public health concern due to its potential use as a bioterrorism agent. For this reason, extensive efforts have been underway to develop antidotes against this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214e21e35c27673686500424d8f47d63
http://www.mdpi.com/2072-6651/3/10/1233/
http://www.mdpi.com/2072-6651/3/10/1233/
Autor:
Lawrence A. Manzano, Eric V. Anslyn, Karl R. Jasheway, Jon D. Robertus, Yan Bai, Jeff M. Pruet
Publikováno v:
European Journal of Medicinal Chemistry. 46:3608-3615
Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d671daa1725f57bc23b366b5bb93c0
https://doi.org/10.1016/j.ejmech.2011.05.025
https://doi.org/10.1016/j.ejmech.2011.05.025