Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jon D. Goguen"'
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Rapid growth in deep tissue is essential to the high virulence of Yersinia pestis, causative agent of plague. To better understand the mechanisms underlying this unusual ability, we used transposon mutagenesis and high-throughput sequencing
Externí odkaz:
https://doaj.org/article/669f11aa0a76439dbf5546c1a1894602
Autor:
Dmitry Ratner, M Pontus A Orning, Megan K Proulx, Donghai Wang, Mikhail A Gavrilin, Mark D Wewers, Emad S Alnemri, Peter F Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D Goguen, Egil Lien
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006035 (2016)
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS co
Externí odkaz:
https://doaj.org/article/7e19901ed97f4246a3cd738ecfdae743
Autor:
Jon D. Goguen, Milka Koupenova, Samantha G. Palace, Jane E. Freedman, Olga Vitseva, Megan K. Proulx
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 18(12)
Background Platelets are classically recognized for their role in hemostasis and thrombosis. Recent work has demonstrated that platelets can also execute a variety of immune functions. The dual prothrombotic and immunological roles of platelets sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ddee3ba7c4609880e3ee4f533dff50
https://pubmed.ncbi.nlm.nih.gov/33467844
https://pubmed.ncbi.nlm.nih.gov/33467844
Autor:
Bodduluri Haribabu, Matthew B. Lawrenz, Silvia M. Uriarte, Samantha G. Palace, Shane A. Reeves, Aruna Vashishta, Jon D. Goguen, Amanda R. Pulsifer, Megan K. Proulx, Jennifer K. Wolfe, Sobha R. Bodduluri
Publikováno v:
Infect Immun
Yersinia pestis causes a rapid, lethal disease referred to as plague. Y. pestis actively inhibits the innate immune system to generate a noninflammatory environment during early stages of infection to promote colonization. The ability of Y. pestis to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151103d20d42482b8226d568cb81cc3e
https://pubmed.ncbi.nlm.nih.gov/31871100
https://pubmed.ncbi.nlm.nih.gov/31871100
Autor:
Bettina L. Lee, Michelle A. Kelliher, Shiyu Xia, Katherine A. Fitzgerald, Peter J. Gough, Pontus Orning, Jon D. Goguen, Egil Lien, Nobuhiko Kayagaki, Alexandria Brooks, Megan K. Proulx, Dan Weng, Hao Wu, Zachary Best, Kristian K. Starheim, Scott B. Berger, Dmitry Ratner, John Bertin
Publikováno v:
Science (New York, N.Y.). 362(6418)
Limited proteolysis of gasdermin D (GSDMD) generates an N-terminal pore-forming fragment that controls pyroptosis in macrophages. GSDMD is processed via inflammasome-activated caspase-1 or -11. It is currently unknown whether macrophage GSDMD can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d211c02f073b05269712ca1cd68463b2
https://pubmed.ncbi.nlm.nih.gov/30361383
https://pubmed.ncbi.nlm.nih.gov/30361383
Publikováno v:
Infection and immunity. 86(9)
Virulence of Yersinia pestis in mammals requires the type III secretion system, which delivers seven effector proteins into the cytoplasm of host cells to undermine immune responses. All seven of these effectors are conserved across Y. pestis strains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35706b8addc0e56331f654d03ff52b44
https://pubmed.ncbi.nlm.nih.gov/29891548
https://pubmed.ncbi.nlm.nih.gov/29891548
Virulence ofYersinia pestisin mammals requires the type III secretion system, which delivers seven effector proteins into the cytoplasm of host cells to undermine immune responses. All seven of these effectors are conserved acrossY. pestisstrains, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e720f749e4d0fc19a9d5bb7c8785a862
https://doi.org/10.1101/310243
https://doi.org/10.1101/310243
Autor:
Megan K. Proulx, Egil Lien, Mikhail A. Gavrilin, Bettina L. Lee, Mark D. Wewers, Jon D. Goguen, Donghai Wang, M. Pontus A. Orning, Peter F. Johnson, Dmitry Ratner, Emad S. Alnemri, Nobuhiko Kayagaki, Joan Mecsas
Publikováno v:
PLoS Pathogens, Vol 12, Iss 12, p e1006035 (2016)
PLoS Pathogens
PLoS Pathogens
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a4d211012065f4658c7fab0ec6a9a2
http://europepmc.org/articles/PMC5135138?pdf=render
http://europepmc.org/articles/PMC5135138?pdf=render
Autor:
Robyn Marty-Roix, Egil Lien, Megan K. Proulx, Jon D. Goguen, M. Pontus A. Orning, Kristian K. Starheim, Dmitry Ratner
Publikováno v:
The Journal of biological chemistry. 291(31)
Innate immunity plays a central role in resolving infections by pathogens. Host survival during plague, caused by the Gram-negative bacterium Yersinia pestis, is favored by a robust early innate immune response initiated by IL-1β and IL-18. These cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6c13782abe4bd17ffe9104a3a75548
https://pubmed.ncbi.nlm.nih.gov/26884330
https://pubmed.ncbi.nlm.nih.gov/26884330
Publikováno v:
Vaccine
The use of a DNA immunization approach to deliver protective antigens against Yersinia pestis (Y. pestis) has been successful in previously reported studies. In the current study, the gene designs for V and F1, two well-studied virulent factors servi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de5cbb58ab3cbc3e81c4f25afa52557