Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jon D Wright"'
Publikováno v:
eLife, Vol 13 (2024)
Experimental detection of residues critical for protein–protein interactions (PPI) is a time-consuming, costly, and labor-intensive process. Hence, high-throughput PPI-hot spot prediction methods have been developed, but they have been validated us
Externí odkaz:
https://doaj.org/article/02fbed149f19420a840b80310265b0b7
Publikováno v:
Journal of Chemical Information and Modeling. 62:1052-1060
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4c7a7176ffdcaa6ba3c6afb94823412
https://doi.org/10.1021/acs.jcim.2c00025
https://doi.org/10.1021/acs.jcim.2c00025
Publikováno v:
The FASEB Journal. 33:9182-9193
Soluble klotho (sKlotho), the shed ectodomain of α-klotho, protects the heart by down-regulating transient receptor potential canonical isoform 6 (TRPC6)-mediated calcium signaling. Binding to α2-3-sialyllactose moiety of gangliosides in lipid raft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c0dddc2f6813c64987c72e1e22e7c8
https://doi.org/10.1096/fj.201900321r
https://doi.org/10.1096/fj.201900321r
Autor:
Jon D. Wright, Sheila S. David, C. Satheesan Babu, Jeremy A. Armas, Jensen M. Spear, Nicole N. Nuñez, Carmay Lim, Anisha N. Rajavel, Justin B. Siegel, Steve J. Bertolani, Cindy Khuu
Publikováno v:
Journal of the American Chemical Society. 140:13260-13271
The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8-oxoguanine (8-oxoG):A mismatches. The importance of this mutation suppression activity in tumor suppressor ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60e5e474f1d1a4f641c803c7772761e1
https://doi.org/10.1021/jacs.8b06923
https://doi.org/10.1021/jacs.8b06923
Autor:
Nicole N, Nuñez, Cindy, Khuu, C Satheesan, Babu, Steve J, Bertolani, Anisha N, Rajavel, Jensen E, Spear, Jeremy A, Armas, Jon D, Wright, Justin B, Siegel, Carmay, Lim, Sheila S, David
Publikováno v:
Journal of the American Chemical Society. 140(41)
The DNA base excision repair (BER) glycosylase MUTYH prevents DNA mutations by catalyzing adenine (A) excision from inappropriately formed 8-oxoguanine (8-oxoG):A mismatches. The importance of this mutation suppression activity in tumor suppressor ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f63442326cd9e6cba7f70fb1ef2aaaf
https://pubmed.ncbi.nlm.nih.gov/30208271
https://pubmed.ncbi.nlm.nih.gov/30208271
Autor:
Jon D. Wright, Noelynn Oliver, Nicole Nischan, Joonho Yoon, Sung Wan An, Jennifer J. Kohler, Jian Xie, Chou Long Huang, Carmay Lim
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31(8)
Soluble Klotho (sKlotho) is the shed ectodomain of antiaging membrane Klotho that contains 2 extracellular domains KL1 and KL2, each of which shares sequence homology to glycosyl hydrolases. sKlotho elicits pleiotropic cellular responses with a poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd48f373b9e06e1dc12b33a3366f281e
https://pubmed.ncbi.nlm.nih.gov/28442546
https://pubmed.ncbi.nlm.nih.gov/28442546
Publikováno v:
Nucleic Acids Research
DR_bind is a web server that automatically predicts DNA-binding residues, given the respective protein structure based on (i) electrostatics, (ii) evolution and (iii) geometry. In contrast to machine-learning methods, DR_bind does not require a train
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e81e693722c83010cf8f885a8e1e166
https://doi.org/10.1093/nar/gks481
https://doi.org/10.1093/nar/gks481
Autor:
Jon D. Wright, Carmay Lim
Publikováno v:
Journal of Biosciences. 32:827-839
Over 50% of all human cancers involve p53 mutations,which occur mostly in the sequence-specific DNA-binding central domain (p53c), yielding little/non-detectable af?nity to the DNA consensus site. Despite our current understanding of protein-DNA reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edafcaa36e91cccd766dce3276f30410
https://doi.org/10.1007/s12038-007-0083-3
https://doi.org/10.1007/s12038-007-0083-3
Publikováno v:
Scientific Reports
Omalizumab, an anti-IgE antibody, used to treat severe allergic asthma and chronic idiopathic urticaria, binds to IgE in blood or membrane-bound on B lymphocytes but not to IgE bound to its high (FcεRI) or low (CD23) affinity receptor. Mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb27bd6fb54d643d3dc1cf97c06f20e
http://europepmc.org/articles/PMC4481376
http://europepmc.org/articles/PMC4481376
Autor:
Raphael A. G. Chaleil, Carmay Lim, Tammy M. K. Cheng, Paul A. Bates, Sebastian Heeger, Aengus Stewart, Nik Matthews, Jon D. Wright, Frank Uhlmann
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395da5e08b1392954a84edbd68c82b07
https://doi.org/10.7554/elife.05565
https://doi.org/10.7554/elife.05565