Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jon C Mirsalis"'
Autor:
Yu Cong, Julie Dyall, Brit J Hart, Lisa Evans DeWald, Joshua C Johnson, Elena Postnikova, Huanying Zhou, Robin Gross, Oscar Rojas, Isis Alexander, Nicole Josleyn, Tengfei Zhang, Julia Michelotti, Krisztina Janosko, Pamela J Glass, Mike Flint, Laura K McMullan, Christina F Spiropoulou, Tim Mierzwa, Rajarshi Guha, Paul Shinn, Sam Michael, Carleen Klumpp-Thomas, Crystal McKnight, Craig Thomas, Ann E Eakin, Kathleen G O'Loughlin, Carol E Green, Paul Catz, Jon C Mirsalis, Anna N Honko, Gene G Olinger, Richard S Bennett, Michael R Holbrook, Lisa E Hensley, Peter B Jahrling
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166318 (2016)
In the fall of 2014, an international news agency reported that patients suffering from Ebola virus disease (EVD) in Liberia were treated successfully with lamivudine, an antiviral drug used to treat human immunodeficiency virus-1 and hepatitis B vir
Externí odkaz:
https://doaj.org/article/46cb98f2678f4277aab2f35637509fbf
Autor:
Yizhe Chen, Fangyi Zhu, Jared Hammill, Gloria Holbrook, Lei Yang, Burgess Freeman, Karen L. White, David M. Shackleford, Kathleen G. O’Loughlin, Susan A. Charman, Jon C. Mirsalis, R. Kiplin Guy
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021)
Abstract Background The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable cl
Externí odkaz:
https://doaj.org/article/ab8cf99d57bd45dc8262fb7f25bbd884
Autor:
Courtney L. Finch, Julie Dyall, Shuang Xu, Elizabeth A. Nelson, Elena Postnikova, Janie Y. Liang, Huanying Zhou, Lisa Evans DeWald, Craig J. Thomas, Amy Wang, Xin Xu, Emma Hughes, Patrick J. Morris, Jon C. Mirsalis, Linh H. Nguyen, Maria P. Arolfo, Bryan Koci, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Connie Schmaljohn, Lisa M. Johansen, Gene G. Olinger, Joshua T. Schiffer, Judith M. White
Publikováno v:
Microorganisms, Vol 9, Iss 3, p 566 (2021)
Outbreaks of Ebola ebolavirus (EBOV) have been associated with high morbidity and mortality. Milestones have been reached recently in the management of EBOV disease (EVD) with licensure of an EBOV vaccine and two monoclonal antibody therapies. Howeve
Externí odkaz:
https://doaj.org/article/82de7543d8574e21bfe1a76eb2884bfa
Autor:
Kathleen O’Loughlin, Yizhe Chen, Lei Yang, Fangyi Zhu, Jared T. Hammill, Karen L. White, Gloria Holbrook, David M. Shackleford, Susan A. Charman, Jon C. Mirsalis, R. Kiplin Guy, Burgess B. Freeman
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-15 (2021)
Malaria Journal
Malaria Journal
Background The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable clinical ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9272764eac4761c57cf5d92db22299b
https://doaj.org/article/ab8cf99d57bd45dc8262fb7f25bbd884
https://doaj.org/article/ab8cf99d57bd45dc8262fb7f25bbd884
Autor:
Joshua T. Schiffer, Craig J. Thomas, Xin Xu, Patrick Morris, Lisa E. Hensley, Elena Postnikova, Peter B. Jahrling, Lisa M. Johansen, Judith M. White, Lisa Evans DeWald, Elizabeth A. Nelson, Maria P. Arolfo, Michael R. Holbrook, Linh H. Nguyen, Courtney L. Finch, Amy Wang, Emma Hughes, Gene G. Olinger, Julie Dyall, Huanying Zhou, Shuang Xu, Bryan Koci, Janie Y. Liang, Connie S. Schmaljohn, Jon C. Mirsalis
Publikováno v:
Microorganisms
Volume 9
Issue 3
Microorganisms, Vol 9, Iss 566, p 566 (2021)
Volume 9
Issue 3
Microorganisms, Vol 9, Iss 566, p 566 (2021)
Outbreaks of Ebola ebolavirus (EBOV) have been associated with high morbidity and mortality. Milestones have been reached recently in the management of EBOV disease (EVD) with licensure of an EBOV vaccine and two monoclonal antibody therapies. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35cac0df8ff6c807ce40232c80fc513b
Autor:
Yizhe Chen, Fangyi Zhu, Jared Hammill, Gloria Holbrook, Lei Yang, Burgess Freeman, Karen L White, David M Shackleford, Kathleen G O’Loughlin, Liang Tang, Susan A Charman, Jon C Mirsalis, R Kiplin Guy
Background: The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing chemotherapies. One critical step in drug development is selecting a suitable clinical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba5e3233c672568a3f49d3cf9baf1cc
https://doi.org/10.21203/rs.3.rs-60168/v1
https://doi.org/10.21203/rs.3.rs-60168/v1
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:2787-2787
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d5e462c5bcc4f5725dfa58d8d246931
https://doi.org/10.1007/s00216-022-03957-0
https://doi.org/10.1007/s00216-022-03957-0
Autor:
Lisa E. Hensley, Jon C. Mirsalis, William E. Dowling, Lisa Evans DeWald, Dawn M. Gerhardt, Lisa Torzewski, Liang Tang, Janet Gahagen, Julie Dyall, Elena Postnikova, Krisztina Janosko, Carol E. Green, Peter B. Jahrling, Joshua C. Johnson, Louis Huzella, Blaire L. Osborn, Ann E. Eakin, Michael R. Holbrook, Anna N. Honko
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
During the Ebola virus disease (EVD) epidemic in Western Africa (2013‒2016), antimalarial treatment was administered to EVD patients due to the high coexisting malaria burden in accordance with World Health Organization guidelines. In an Ebola trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df00547ee68ae0e8fa0dd7bd3a132b88
Autor:
Huanying Zhou, Gene G. Olinger, Kathleen O’Loughlin, Joshua C. Johnson, Richard S. Bennett, Julia Michelotti, Anna N. Honko, Carol E. Green, Lisa E. Hensley, Yu Cong, Dawn M. Gerhardt, Steven E. Kern, Brit J. Hart, Lisa Evans DeWald, Jon C. Mirsalis, Peter B. Jahrling, Elena Postnikova, Julie Dyall
Publikováno v:
The Journal of Infectious Diseases. 218:S592-S596
At the onset of the 2013-2016 epidemic of Ebola virus disease (EVD), no vaccine or antiviral medication was approved for treatment. Therefore, considerable efforts were directed towards the concept of drug repurposing or repositioning. Amiodarone, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ee92f5b100e0badb2a7fdbd09cdbbb
https://doi.org/10.1093/infdis/jiy345
https://doi.org/10.1093/infdis/jiy345
Autor:
Alexander V. Kurkin, Young Do Kwon, Dmitry S. Belov, Patricia C. Byrge, Asim K. Debnath, Anna M. Furimsky, Ranjith R. Ramesh, Andrea Altieri, Lalitha V. Iyer, Francesca Curreli, Jon C. Mirsalis, Kathleen O’Loughlin
Publikováno v:
European Journal of Medicinal Chemistry. 154:367-391
We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and ADMET properties. In this report, we present a st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611d99713a69636ddb353a6e82f6f3a6
https://doi.org/10.1016/j.ejmech.2018.04.062
https://doi.org/10.1016/j.ejmech.2018.04.062