Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jon B. Catterall"'
Autor:
Lakshminarayan R. Ranganath, Janet L. Huebner, James A. Gallagher, Virginia B. Kraus, M.-F. Hsueh, J.P. Dillon, Adam Michael Taylor, Jon B. Catterall
Publikováno v:
RHEUMATOLOGY
Objective. Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32db4e2605d866ee690fb0db66551aca
Autor:
Constance E. Brinckerhoff, B. A. Degnan, P. J. T. Koshy, W. D. Shingleton, Andrew D. Rowan, Joni L. Rutter, Jon B. Catterall, Tim E. Cawston, S. Carrère
Publikováno v:
Arthritis & Rheumatism. 44:2296-2310
Objective To investigate the mechanism of interleukin-1α (IL-1α) and oncostatin M (OSM) synergistic regulation of matrix metalloproteinase 1 (MMP-1) in human chondrocytes. Methods Using an immortalized human chondrocyte cell line (T/C28a4), we inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bdf153701c6cac9d77bbf2528138745
https://doi.org/10.1002/1529-0131(200110)44:10<2296::aid-art392>3.0.co
https://doi.org/10.1002/1529-0131(200110)44:10<2296::aid-art392>3.0.co
Autor:
Tim E. Cawston, Sarah Elliott, Andrew D. Rowan, Bill Shingleton, Severine Carrere, Richard Duggleby, Jon B. Catterall
Publikováno v:
Chronic Obstructive Pulmonary Disease: Pathogenesis to Treatment: Novartis Foundation Symposium 234
The matrix metalloproteinases (MMPs) are a unique family of metalloenzymes that, once activated, can destroy connective tissue. The active enzymes are all inhibited by tissue inhibitors of metalloproteinases (TIMPs). The relative amounts of active MM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad6fc84179191c50f0500ec5e9fce066
https://doi.org/10.1002/0470868678.ch13
https://doi.org/10.1002/0470868678.ch13
Publikováno v:
Biochemical Society symposium. (70)
We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ec700c9013d47d7f5159a8ecc54266
https://pubmed.ncbi.nlm.nih.gov/14587288
https://pubmed.ncbi.nlm.nih.gov/14587288
Autor:
Jon B, Catterall, Tim E, Cawston
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f4d7f1e6af7b32ab505fcf107829e6b
https://pubmed.ncbi.nlm.nih.gov/12769502
https://pubmed.ncbi.nlm.nih.gov/12769502
Autor:
Jon B. Catterall, Tim E. Cawston
Publikováno v:
Arthritis Research & Therapy. 5:12
The destruction of bone and cartilage is characteristic of the progression of musculoskeletal diseases. The present review discusses the developments made with two different classes of drugs, the bisphosphonates and matrix metalloproteinase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c8003d290d9aff9491cef25ca5bd3d
https://doi.org/10.1186/ar604
https://doi.org/10.1186/ar604