Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jon Ainsley"'
Autor:
Jon Ainsley, Adrian J. Mulholland, Gary W. Black, Olivier Sparagano, Christo Z. Christov, Tatyana G. Karabencheva-Christova
Publikováno v:
ACS Omega, Vol 3, Iss 5, Pp 4847-4859 (2018)
Externí odkaz:
https://doaj.org/article/67213a5ff49f4d30bdfeb74d2a25d416
Publikováno v:
Journal of Chemical Information and Modeling
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Dipòsit Digital de la UB
Universidad de Barcelona
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Dipòsit Digital de la UB
Universidad de Barcelona
The use of broadly neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1) has been shown to be a promising therapeutic modality in the prevention of HIV infection. Understanding the b12–gp120 binding mechanism under physiologic
Autor:
Mare Cudic, Enbo Liu, Tatyana G. Karabencheva-Christova, Austin B. Yongye, Karina Martinez Mayorga, Mihael Cudic, Jon Ainsley, Predrag Cudic, Maria C. Rodriguez, Barbara M. Mueller, Christo Z. Christov
Publikováno v:
Amino Acids. 49:1867-1883
The transformation from normal to malignant phenotype in human cancers is associated with aberrant cell-surface glycosylation. Thus, targeting glycosylation changes in cancer is likely to provide not only better insight into the roles of carbohydrate
Autor:
Jon Ainsley, Tatyana G. Karabencheva-Christova, Rajeev Ramanan, Martin Evison, Shobhit S. Chaturvedi, Christopher J. Schofield, Jennifer M. Ames, Christo Z. Christov, Sodiq O. Waheed
The human KDM7 subfamily histone H3 Nɛ‐methyl lysine demethylases PHF8 (KDM7B) and KIAA1718 (KDM7A) have different substrate selectivities and are linked to genetic diseases and cancer. We describe experimentally based computational studies reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6c209cd8aa2b68a7a4acddf0307780
Autor:
Tatyana G. Karabencheva-Christova, Jon Ainsley, Martin Evison, Sodiq O. Waheed, Shobhit S. Chaturvedi, Christopher J. Schofield, Rajeev Ramanan, Jennifer M. Ames, Christo Z. Christov
N-Methylation of DNA/RNA bases can be regulatory or damaging and is linked to diseases including cancer and genetic disorders. Bacterial AlkB and human FTO are DNA/RNA demethylases belonging to the Fe(II) and 2-oxoglutarate oxygenase superfamily. Mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c1490362d6a32f25213a3f70fe733d
https://doi.org/10.1039/c9ob00162j
https://doi.org/10.1039/c9ob00162j
Autor:
Jon, Ainsley, Alessio, Lodola, Adrian J, Mulholland, Christo Z, Christov, Tatyana G, Karabencheva-Christova
Publikováno v:
Advances in protein chemistry and structural biology. 113
The combined quantum mechanics/molecular mechanics (QM/MM) methods have become a valuable tool in computational biochemistry and received versatile applications for studying the reaction mechanisms of enzymes. The approach combines the calculations o
Autor:
Christo Z. Christov, Marina Tanasova, Shobhit S. Chaturvedi, Jon Ainsley, Tatyana G. Karabencheva-Christova
Publikováno v:
Chemical communications (Cambridge, England). 54(71)
Fructose transporter GLUT5 is characterized by unusual substrate specificity and is linked to a variety of metabolic disorders. A series of high-affinity GLUT5-specific sugar-based probes – ManCous – have been very recently described and efficien
Autor:
Olivier Sparagano, Jon Ainsley, Christo Z. Christov, Gary W. Black, Tatyana G. Karabencheva-Christova, Adrian J. Mulholland
Publikováno v:
Ainsley, J, Mulholland, A J, Black, G W, Sparagano, O, Christov, C Z & Karabencheva-Christova, T G 2018, ' Structural Insights from Molecular Dynamics Simulations of Tryptophan 7-Halogenase and Tryptophan 5-Halogenase ', ACS Omega, vol. 3, no. 5, pp. 4847-4859 . https://doi.org/10.1021/acsomega.8b00385
ACS Omega, Vol 3, Iss 5, Pp 4847-4859 (2018)
ACS Omega
ACS Omega, Vol 3, Iss 5, Pp 4847-4859 (2018)
ACS Omega
Many natural organic compounds with pharmaceutical applications, including antibiotics (chlortetracycline and vancomycin), antifungal compounds (pyrrolnitrin), and chemotherapeutics (salinosporamide A and rebeccamycin) are chlorinated. Halogenating e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d367049d3d299150e3ec55f741dd9baa
https://research-information.bris.ac.uk/en/publications/0dab3f09-ca69-4ae6-a4cf-caa35fe27cf2
https://research-information.bris.ac.uk/en/publications/0dab3f09-ca69-4ae6-a4cf-caa35fe27cf2
Autor:
Mingxi Fang, Rashmi Adhikari, Haiying Liu, Nathan Conner, Ashutosh Tiwari, Jianbo Wang, Jianheng Bi, Nethaniah Dorh, Tatyana G. Karabencheva-Christova, Wafa Mazi, Fen-Tair Luo, Jon Ainsley
Publikováno v:
Journal of materials chemistry. B. 5(48)
We report five fluorescent probes based on coumarin-hybridized fluorescent dyes with spirolactam ring structures (A–E) to detect pH changes in live cells by monitoring visible and near-infrared fluorescence changes. Under physiological or basic con
Autor:
Alessio Lodola, Tatyana G. Karabencheva-Christova, Adrian J. Mulholland, Jon Ainsley, Christo Z. Christov
The combined quantum mechanics/molecular mechanics (QM/MM) methods have become a valuable tool in computational biochemistry and received versatile applications for studying the reaction mechanisms of enzymes. The approach combines the calculations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8e4f581d0bc64aada4569a51acebc3
https://doi.org/10.1016/bs.apcsb.2018.07.001
https://doi.org/10.1016/bs.apcsb.2018.07.001