Flaxseed-enriched diets change milk concentration of the antimicrobial danofloxacin in sheep

Autor: Jon Andoni Otero, Dafne García-Mateos, Indira Alvarez-Fernández, Rocío García-Villalba, Juan Carlos Espín, Ana Isabel Álvarez, Gracia Merino

Publikováno v: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-8 (2018)

Abstract Background Flaxseed is the most common and rich dietary source of lignans and is an acceptable supply of energy for livestock. Flaxseed lignans are precursors of enterolignans, mainly enterolactone and enterodiol, produced by the rumen and i

Externí odkaz: https://doaj.org/article/8158d1583f5740d28a81b0585998504e

ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release

Autor: Piet Borst, Koen van de Wetering, Jon A. Otero, Sunny Sapthu, Marcel de Haas, Asli Kucukosmanoglu, Theo G. M. F. Gorgels, Robert S. Jansen, Arthur A.B. Bergen, Ilse E. M. Hegman

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20206-20211. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 110, 20206-20211. National Academy of Sciences
Jansen, R S, Küçükosmanoǧlu, A, De Haas, M, Sapthu, S, Otero, J A, Hegman, I E M, Bergen, A A B, Gorgels, T G M F, Borst, P & Van De Wetering, K 2013, ' ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release ', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 50, pp. 20206-20211 . https://doi.org/10.1073/pnas.1319582110

Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease characterized by progressive ectopic mineralization of the skin, eyes, and arteries, for which no effective treatment exists. PXE is caused by inactivating mutations in the gene encodin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b31be1682a2a3991d0f478d83613a89
https://doi.org/10.1073/pnas.1319582110

The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system

Autor: Ana Guijarro, Ana I. Alvarez, Jon A. Otero, Gracia Merino, Tiziano Bandiera, Daniele Piomelli, Borja Barrera, Guillermo Moreno-Sanz, Ilaria d’Elia

Publikováno v: Pharmacological Research. 64:359-363

The O-arylcarbamate URB937 is a potent inhibitor of fatty-acid amide hydrolase (FAAH), an intracellular serine hydrolase responsible for the deactivation of the endocannabinoid anandamide. URB937 is unique among FAAH inhibitors in that is actively ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cb417c524a4c9551bf7794ebef2bb5
https://doi.org/10.1016/j.phrs.2011.07.001

Role of ABCG2 in transport of the mammalian lignan enterolactone and its secretion into milk in Abcg2 knockout mice

Autor: Francisco A. Tomás-Barberán, Gracia Merino, Jon A. Otero, Juan Carlos Espín, Rocío García-Villalba, Verónica Miguel, Ana I. Alvarez

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 42(5)

Lignans are phytoestrogens that are metabolized by the gut microbiota to enterodiol and enterolactone, the main biologically active enterolignans. Substantial interindividual variation in plasma concentration and urinary excretion of enterolignans ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e13569e3d4409cace6fbbe3afe0c7de
https://pubmed.ncbi.nlm.nih.gov/24568887

The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP

Autor: Julio G. Prieto, Anna Seelig, Estefanía Egido, Gracia Merino, Borja Barrera, Ana I. Alvarez, Jon A. Otero

ABCG2/BCRP is an ATP-binding cassette transporter that extrudes compounds from cells in the intestine, liver, kidney, and other organs, such as the mammary gland, affecting pharmacokinetics and milk secretion of antibiotics, anticancer drugs, and oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af50120de5500f5674d835c495d45f97
https://europepmc.org/articles/PMC3393426/