Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jon A. Klover"'
Publikováno v:
Collective Bargaining by Government Workers: The Public Employee ISBN: 9781315224978
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e53289e415ef27cc65e40000b081e7da
https://doi.org/10.4324/9781315224978-12
https://doi.org/10.4324/9781315224978-12
Autor:
Jon A. Klover, Francis M. Sverdrup, Lillian E. Vickery, Lily R.-H. Song, Charles P. Anglin, Thomas P. Misko, Matthew P. Yates
Publikováno v:
Osteoarthritis and Cartilage. 18(7):948-955
Summary Objective Statins possess anti-inflammatory properties. This study was undertaken to characterize the mechanism of action of statin drugs on collagenase expression in primary human osteoarthritic cartilage tissue. Method Human articular chond
Autor:
Srinivasan Nagarajan, Ish K. Libertyville Khanna, Tiffany Duffin, Alan F. Gasiecki, Jeffery L. Keene, Mihir D. Parikh, Michael Clare, Marisa M. Westlin, Maureen A. Nickols, Christina A. Steininger, Melanie L. Williams, Hwang-Fun Lu, Thomas Rogers, Jon A. Klover, Mary Beth Finn, V. Wayne Engleman, Sandra K. Freeman, William F. Westlin, Barbara B. Chen, G. Alan Nickols, Kristen E. Shannon, Mark A. Russell, Bipinchandra N. Desai
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:3390-3412
The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small molecules that inhibit the integrin have been shown to suppress tumor growth and retinal angioge
Autor:
Tiffany Duffin, Maureen A. Nickols, Barbara B. Chen, Mary Beth Finn, Mark A. Russell, William F. Westlin, Steven L. Settle, Mark L. Boys, Randall K. Rader, Jon A. Klover, Wang Yaping, Thomas D. Penning, Jeffery L. Keene, V. Wayne Engleman, G. Allen Nickols, Christina N. Steininger, Sandra K. Freeman, Melanie L. Hanneke, Khilevich Albert, Marisa M. Westlin, Kristen E. Shannon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3156-3161
We describe a series of pyrazole and isoxazole analogs as antagonists of the α v β 3 receptor. Compounds showed low to sub-nanomolar potency against α v β 3 , as well as good selectivity against α IIb β 3 . In HT29 cells, most analogs also demo
Autor:
Mary Beth Finn, Hongwei Wu, Kristen E. Shannon, V. Wayne Engleman, Maureen A. Nickols, Jon A. Klover, Marissa Westlin, Tiffany Duffin, Christina N. Steininger, G. Allen Nickols, Thomas D. Penning, Melanie L. Hanneke, John A. Wendt, Heather Stenmark, Mark A. Russell, Jeffery L. Keene, Downs Victoria Leigh, William F. Westlin, Barbara B. Chen, Wang Yaping, Sandra K. Freeman, Mark L. Boys
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:845-849
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6. These analogs were demonstrated to
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Autor:
Srinivasan Nagarajan, G. Alan Nickols, Jon A. Klover, David W. Griggs, Sandra K. Freeman, V. Wayne Engleman, Jane M. Meyer, Julie M. Miyashiro
Publikováno v:
Chemical Biology Drug Design. 67:177-181
A peptidomimetic inhibitor of the integrin alpha(v)beta(3) has been substantially modified to produce several new nonpeptidic antagonists. These inhibitors are simpler to synthesize and belong to new classes of scaffolds. Some of the compounds served
Autor:
Jeng-Jong Shieh, Peter O. Olins, Maire Helena Caparon, William F. Hood, Kumnan Paik, Ann M. Donnelly, Bauer Christopher S, John P. McKearn, Sarah R. Braford, Polazzi Joseph O, John W. Thomas, Jon A. Klover, Alan Michael Easton, David L. Zeng, Mark Allen Abrams, Joseph K. Welply, Barbara K. Klein
Publikováno v:
Experimental Hematology. 27:1746-1756
A combinatorial mutagenesis strategy was used to create a collection of nearly 500 variants of human interleukin 3 (IL-3), each with four to nine amino acid substitutions clustered within four linear, nonoverlapping regions of the polypeptide. The va
Autor:
Jon A. Klover, Nalini Sadagopan, Yanhua Zhang, Gabriella Szekely-Klepser, Wenlin Li, Dawn Dufield, Christopher Lepsy
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(5-6)
An LC-MS/MS method was developed and validated to quantify endogenous cyclic guanosine 3',5'-monophosphate (cGMP) in human plasma. The LC-MS/MS and competitive enzyme immunoassay (EIA) assays were compared. cGMP concentrations of 20 human plasma samp
Autor:
Thomas D, Penning, Albert, Khilevich, Barbara B, Chen, Mark A, Russell, Mark L, Boys, Yaping, Wang, Tiffany, Duffin, V Wayne, Engleman, Mary Beth, Finn, Sandra K, Freeman, Melanie L, Hanneke, Jeffery L, Keene, Jon A, Klover, G Allen, Nickols, Maureen A, Nickols, Randall K, Rader, Steven L, Settle, Kristen E, Shannon, Christina N, Steininger, Marisa M, Westlin, William F, Westlin
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(12)
We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against alpha(v)beta3, as well as good selectivity against alpha(IIb)beta3. In HT29 cells, most analogs