Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jon A. Appel"'
Autor:
Phaedra Geer, Marc A. Giulianotti, Skye R. Doering, Travis M. Lavoi, Mark D. Ericson, Radleigh Santos, Katie T. Freeman, Carrie Haskell-Luevano, Richard A. Houghten, Jon R. Appel, Ginamarie Debevec, Clemencia Pinilla
Publikováno v:
J Med Chem
The central melanocortin-3 and melanocortin-4 receptors (MC3R, MC4R) are key regulators of body weight and energy homeostasis. Herein, the discovery and characterization of first-in-class small molecule melanocortin agonists with selectivity for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9eb1c484c45bcbe6d841d2afad5501
https://doi.org/10.1021/acs.jmedchem.0c02041
https://doi.org/10.1021/acs.jmedchem.0c02041
Autor:
Richard A. Houghten, Larry A. Sklar, Bruce S. Edwards, Marc A. Giulianotti, Jon R. Appel, Radleigh G. Santos, Clemencia Pinilla
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6408-6424 (2013)
In the past 20 years, synthetic combinatorial methods have fundamentally advanced the ability to synthesize and screen large numbers of compounds for drug discovery and basic research. Mixture-based libraries and positional scanning deconvolution com
Externí odkaz:
https://doaj.org/article/b974e2ed0f72410596a318605633433d
Autor:
Austin B Yongye, Mirella Vivoli, Iris Lindberg, Jon R Appel, Richard A Houghten, Karina Martinez-Mayorga
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56957 (2013)
The calcium-dependent serine endoproteases prohormone convertase 1/3 (PC1/3) and prohormone convertase 2 (PC2) play important roles in the homeostatic regulation of blood glucose levels, hence implicated in diabetes mellitus. Specifically, the absenc
Externí odkaz:
https://doaj.org/article/6f958fffc0a44c8babe76c149820aa7e
Autor:
Valeria Judkowski, Alcinette Bunying, Feng Ge, Jon R Appel, Kingyee Law, Atima Sharma, Claudia Raja-Gabaglia, Patricia Norori, Radleigh G Santos, Marc A Giulianotti, Mark K Slifka, Daniel C Douek, Barney S Graham, Clemencia Pinilla
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24091 (2011)
The threat of bioterrorism with smallpox and the broad use of vaccinia vectors for other vaccines have led to the resurgence in the study of vaccinia immunological memory. The importance of the role of CD4+ T cells in the control of vaccinia infectio
Externí odkaz:
https://doaj.org/article/4bf581b95ce242f4a40de4b837bcb637
Autor:
Radleigh G. Santos, Silvia Andrea Longhi, Valeria Judkowski, Gonzalo Raúl Acevedo, Jon R. Appel, Clemencia Pinilla, Karina A. Gómez, Marc A. Giulianotti
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
The prevention and treatment of infectious diseases is highly dependent on the availability of reliable diagnostic tests and protective or therapeutic vaccines. There also exists an urgent need to develop reliable biomarkers to monitor treatment succ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9b1c72f8255b0d9d7b486a6e18934f
https://doi.org/10.1016/j.provac.2015.05.013
https://doi.org/10.1016/j.provac.2015.05.013
Autor:
Skye R. Doering, Radleigh G. Santos, Erica M. Haslach, Robert C. Speth, Jon R. Appel, Sathya M. Schnell, Phaedra Geer, Ginamarie Debevec, Katie T. Freeman, Clemencia Pinilla, Carrie Haskell-Luevano, Marvin L. Dirain, Richard A. Houghten, Marc A. Giulianotti
The centrally expressed melanocortin-3 and -4 receptors (MC3R/MC4R) have been studied as possible targets for weight management therapies, with a preponderance of studies focusing on the MC4R. Herein, a novel tetrapeptide scaffold [Ac-Xaa1 -Arg-(pI)D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd53c4fbe65c709a37cb81ca858a506c
https://europepmc.org/articles/PMC5672800/
https://europepmc.org/articles/PMC5672800/
Autor:
Marc A. Giulianotti, Clemencia Pinilla, José L. Medina-Franco, Bruce S. Edwards, Jon R. Appel, Austin B. Yongye, Larry A. Sklar, Radleigh G. Santos, Richard A. Houghten
Publikováno v:
Journal of Chemical Information and Modeling. 53:1475-1485
We present a general approach to describe the structure-activity relationships (SAR) of combinatorial data sets with activity for two biological endpoints with emphasis on the rapid identification of substitutions that have a large impact on activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73db616d5679a3a239542971a39afa52
https://doi.org/10.1021/ci400192y
https://doi.org/10.1021/ci400192y
Autor:
Dorith Rotenberg, Kara D. Baker, Zhining Ou, Kaylee Hervey, Alma G. Laney, William W. Bockus, Erick D. De Wolf, Jon A. Appel, Anna E. Whitfield
Publikováno v:
Phytopathology. 106(2)
Vector-borne virus diseases of wheat are recurrent in nature and pose significant threats to crop production worldwide. In the spring of 2011 and 2012, a state-wide sampling survey of multiple commercial field sites and university-managed Kansas Agri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b1b8b084cb73aad38e67d78edb24bb
https://pubmed.ncbi.nlm.nih.gov/26799958
https://pubmed.ncbi.nlm.nih.gov/26799958
Autor:
Heidi M Christensen, Niels Fogh-Andersen, Bo Zerahn, Susanne Møller, Bent Ejlertsen, Dorte Nielsen, Jon M Appel, Peter Søgaard, Benny Vittrup Jensen
Publikováno v:
Acta Oncologica. 51:1054-1061
Newer studies raise concern that adjuvant anthracycline treatment for breast cancer (BC) causes long-term heart damage. We aimed to examine whether heart failure or impairment could be demonstrated several years after low-dose epirubicin-based adjuva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba06870b037816cdcdb587e8741195bd
https://doi.org/10.3109/0284186x.2012.702920
https://doi.org/10.3109/0284186x.2012.702920
Autor:
Jon M Appel, Peter Bo Hansen, Kåre Sander, Jacob E. Møller, Anders Krarup-Hansen, Finn Gustafsson
Publikováno v:
Congestive Heart Failure. 18:291-294
Anthracycline treatments are hampered by dose-related cardiotoxicity, frequently leading to heart failure (HF) with a very poor prognosis. The authors report a case of a 19-year-old man developing HF after anthracycline treatment for Ewing sarcoma. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14fbd2c70bbf1ddfedd9e463b9309a6c
https://doi.org/10.1111/j.1751-7133.2012.00291.x
https://doi.org/10.1111/j.1751-7133.2012.00291.x