Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jon Smythe"'
Autor:
Stuart Ellison, Karen Buckland, Yuko Learmonth, Victoria Day, Spandan Kalra, Lauren Howe, Francisco José Roman-Rodriguez, Jose Bonafont, Laura Booth, Rebecca Holley, Jon Smythe, Simon Jones, Adrian Thrasher, Claire Booth, Brian W. Bigger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101271- (2024)
Hematopoietic stem cell gene therapy (HSCGT) is a promising therapeutic strategy for the treatment of neurodegenerative, metabolic disorders. The approach involves the ex vivo introduction of a missing gene into patients’ own stem cells via lentivi
Externí odkaz:
https://doaj.org/article/c6d56cc1cb214a2393e79a6e7acc9046
Autor:
Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Daniel F. McAuley, Cecilia O’Kane
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Mesenchymal stromal cells (MSCs) may be of benefit in ARDS due to immunomodulatory and reparative properties. This trial investigates a novel CD362 enriched umbilical cord derived MSC product (REALIST ORBCEL-C), produced to Good M
Externí odkaz:
https://doaj.org/article/b39f86b9bd8d43d5a0df92ee016b7c98
Autor:
Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Anna Krasnodembskaya, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Daniel F. McAuley, Cecilia M. O'Kane
Publikováno v:
EClinicalMedicine, Vol 41, Iss , Pp 101167- (2021)
Background: Mesenchymal stromal cells (MSCs) may be of benefit in acute respiratory distress syndrome (ARDS) due to immunomodulatory, reparative, and antimicrobial actions. ORBCEL-C is a population of CD362 enriched umbilical cord-derived MSCs. The R
Externí odkaz:
https://doaj.org/article/5d8040571d894196b436d7a7f05aab42
Autor:
Ellen Gorman, Manu Shankar-Hari, Phil Hopkins, William S. Tunnicliffe, Gavin D. Perkins, Jonathan Silversides, Peter McGuigan, Colette Jackson, Roisin Boyle, Jamie McFerran, Cliona McDowell, Christina Campbell, Margaret McFarland, Jon Smythe, Jacqui Thompson, Barry Williams, Gerard Curley, John G. Laffey, Mike Clarke, Cecilia O’Kane, Daniel F. McAuley
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Abstract Objectives The primary objective of the study is to assess the safety of a single intravenous infusion of Mesenchymal Stromal Cells (MSCs) in patients with Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Secondary objectives are
Externí odkaz:
https://doaj.org/article/523540fd733840fda8dfc370803163c3
Autor:
Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams, Harish Poptani, Brian K. Park, Patricia Murray, Bettina Wilm
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)
Abstract Background Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and adverse events are oft
Externí odkaz:
https://doaj.org/article/90b861852cd94ace8b91583c61cbdcce
Autor:
Robert S. Kerbel, Daniel C. Link, Francesco Bertolini, Gordon Rustin, Ian Judson, Paul Nathan, Adrian Harris, Jon Smythe, David J. Chaplin, Emile E. Voest, Jeffrey M. Arbeit, Shi-Rong Cai, Ping Xu, Shan Man, Laura G. Daenen, Jill Woloszynek, Terence Tang, Yuval Shaked
Supplementary Figures 1-2 from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d7e4fc3a049bc155c2e82336f2d7ca
https://doi.org/10.1158/0008-5472.22378397.v1
https://doi.org/10.1158/0008-5472.22378397.v1
Autor:
Robert S. Kerbel, Daniel C. Link, Francesco Bertolini, Gordon Rustin, Ian Judson, Paul Nathan, Adrian Harris, Jon Smythe, David J. Chaplin, Emile E. Voest, Jeffrey M. Arbeit, Shi-Rong Cai, Ping Xu, Shan Man, Laura G. Daenen, Jill Woloszynek, Terence Tang, Yuval Shaked
Supplementary Methods from Contribution of Granulocyte Colony-Stimulating Factor to the Acute Mobilization of Endothelial Precursor Cells by Vascular Disrupting Agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b4f09a6e6ec4a2afb856bfe53d7a1
https://doi.org/10.1158/0008-5472.22378394
https://doi.org/10.1158/0008-5472.22378394
Autor:
Peter McGuigan, Margaret McFarland, Cliona McDowell, Jacqui Thompson, Manu Shankar-Hari, John G. Laffey, Phil Hopkins, Cecilia O'Kane, Gerard F. Curley, Ellen Gorman, Colette Jackson, Gavin D. Perkins, Daniel F. McAuley, Mike Clarke, William Tunnicliffe, Jon Smythe, Jonathan A Silversides, Jamie McFerran, Roisin Boyle, Barry Williams, Anna Krasnodembskaya, Christina Campbell
Publikováno v:
EClinicalMedicine, Vol 41, Iss, Pp 101167-(2021)
EClinicalMedicine
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine-published by THE LANCET, vol. 41, 101167 . https://doi.org/10.1016/j.eclinm.2021.101167
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine, vol. 41 . https://doi.org/10.1016/j.eclinm.2021.101167
EClinicalMedicine
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine-published by THE LANCET, vol. 41, 101167 . https://doi.org/10.1016/j.eclinm.2021.101167
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Krasnodembskaya, A, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, McAuley, D F & O'Kane, C M 2021, ' Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial ', EClinicalMedicine, vol. 41 . https://doi.org/10.1016/j.eclinm.2021.101167
Background Mesenchymal stromal cells (MSCs) may be of benefit in acute respiratory distress syndrome (ARDS) due to immunomodulatory, reparative, and antimicrobial actions. ORBCEL-C is a population of CD362 enriched umbilical cord-derived MSCs. The RE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625418f3f74bca4d6af1f31458d3a812
http://www.sciencedirect.com/science/article/pii/S2589537021004478
http://www.sciencedirect.com/science/article/pii/S2589537021004478
Publikováno v:
Transplantation and cellular therapy. 27(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622fabfd4e21e8529579ab4592a4b7f6
https://pubmed.ncbi.nlm.nih.gov/32717431
https://pubmed.ncbi.nlm.nih.gov/32717431
Autor:
Christina Campbell, Mike Clarke, Ellen Gorman, John G. Laffey, Jacqui Thompson, Phil Hopkins, Gavin D. Perkins, Colette Jackson, Daniel F. McAuley, Jonathan A Silversides, Cliona McDowell, Peter J. McGuigan, Jon Smythe, Gerard F. Curley, Roisin Boyle, Barry Williams, William Tunnicliffe, Jamie McFerran, Margaret McFarland, Manu Shankar-Hari, Cecilia O'Kane
Publikováno v:
Gorman, E, Shankar-Hari, M, Hopkins, P, Tunnicliffe, W S, Perkins, G D, Silversides, J, McGuigan, P, Jackson, C, Boyle, R, McFerran, J, McDowell, C, Campbell, C, McFarland, M, Smythe, J, Thompson, J, Williams, B, Curley, G, Laffey, J G, Clarke, M, O'Kane, C & McAuley, D F 2020, ' Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial ', Trials, vol. 21, no. 1, pp. 462 . https://doi.org/10.1186/s13063-020-04416-w, https://doi.org/10.1186/s13063-020-04416-w
Trials
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Trials
Trials, Vol 21, Iss 1, Pp 1-3 (2020)
Objectives The primary objective of the study is to assess the safety of a single intravenous infusion of Mesenchymal Stromal Cells (MSCs) in patients with Acute Respiratory Distress Syndrome (ARDS) due to COVID-19. Secondary objectives are to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1909d111bf99c230386793115843632e
https://pure.qub.ac.uk/en/publications/repair-of-acute-respiratory-distress-syndrome-by-stromal-cell-administration-in-covid19-realistcovid19-a-structured-summary-of-a-study-protocol-for-a-randomised-controlled-trial(55ff62aa-2ee8-4509-ae9a-bc9b72c12388).html
https://pure.qub.ac.uk/en/publications/repair-of-acute-respiratory-distress-syndrome-by-stromal-cell-administration-in-covid19-realistcovid19-a-structured-summary-of-a-study-protocol-for-a-randomised-controlled-trial(55ff62aa-2ee8-4509-ae9a-bc9b72c12388).html