Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Jon Bordner"'
Autor:
Yves A. Chantigny, Ralph P. Robinson, Kleinman Edward F, Jon Bordner, Patricia A. McNiff, Yuriy A. Abramov, John C. Murray, Michael A. Plotkin, Leonard Buckbinder, Michele L. Millham, Matthew R. Reese, Jean Schaefer
Publikováno v:
Journal of Medicinal Chemistry. 58:2658-2677
A significant improvement in agonist activity of the previously described 2-aryloctahydrophenanthrene-2,3,7-triol series of dissociated glucocorticoid receptor agonists (DAGRs) was achieved by modifying the substitution at C3 from (S)-3-hydroxy to (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca2438a1c9e112c199c73fa8c457da0
https://doi.org/10.1021/jm501601b
https://doi.org/10.1021/jm501601b
Autor:
Steve Finegan, Jennifer L. Liras, John Schafer, Gregory G. Stone, Sarah K. Wade, Ann G. Connolly, Rhonda Monahan, Katherine E. Brighty, Joan Duignan, Steven J. Brickner, Phuong Le, Ivan J. Samardjiev, Richard P. Zaniewski, Dennis Girard, Jon Bordner, Meghan Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:276-279
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31058e211b4e5cd78b92b592ecef72f
https://doi.org/10.1016/j.bmcl.2010.11.022
https://doi.org/10.1016/j.bmcl.2010.11.022
Autor:
Yuriy A. Abramov, John C. Murray, Leonard Buckbinder, Ellen R. Laird, Matthew R. Reese, Kleinman Edward F, Yves A. Chantigny, Matthew David Wessel, E. D. Salter, Sue A. Yocum, Morgan Bradley P, Ralph P. Robinson, Jean Schaefer, Amber I. Haugeto, Jon Bordner, Patricia A. McNiff, Michele L. Millham
Publikováno v:
Journal of Medicinal Chemistry. 52:1731-1743
As exemplified by the lead compound 2, octahydrophenanthrene-2,7-diol analogues exhibit the profile of a pathway-selective or "dissociated" agonist of the glucocorticoid receptor (GR), retaining the potent activity that glucocorticoids have for trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7be2568bff2da7c37818c84b398c67
https://doi.org/10.1021/jm801512v
https://doi.org/10.1021/jm801512v
Autor:
Jon Bordner, Simon Bailey, Charlotte Reed, Doris Greiling, Paul V. Fish, Rob Webster, Andrew B. McElroy, Stephane Billotte, Kim James, James Edward John Mills
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:6562-6567
Succinyl hydroxamates 1 and 2 are disclosed as novel series of potent and selective inhibitors of procollagen C-proteinase (PCP) which may have potential as anti-fibrotic agents. Carboxamide 7 demonstrated good PCP inhibition and had excellent select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c92c914469bf49651d0ef78bb2515dd
https://doi.org/10.1016/j.bmcl.2008.10.036
https://doi.org/10.1016/j.bmcl.2008.10.036
Autor:
Makoto Kawai, Yoshinori Murata, Mio Sakai, Atsushi Omura, Kazunari Hattori, Shinichi Sakemi, Yoko Matsuoka, Ivan J. Samardjiev, Jon Bordner, Morimichi Sato, Takashi Kojima, Takashi Mano
Publikováno v:
International Journal of Pharmaceutics. 355:337-340
(−)-6-{2-[4-(3-Fluorophenyl)-4-hydroxy-piperidin-1-yl]-1-hydroxyethyl}-3,4-dihydro-quinolin-2(1H)-one (compound A) is an NR2B selective N -methyl d -aspartate (NMDA) antagonist that has shown at least two polymorphs, forms I and II. In this report,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8050a9ed33b14d0a18ce1e4c46305dd
https://doi.org/10.1016/j.ijpharm.2007.11.060
https://doi.org/10.1016/j.ijpharm.2007.11.060
Autor:
Marcus Ewing, Stephen E. Hubbs, John VanAlsten, Timothy Norris, Grace O. Jensen, Matthew L. Jorgensen, Weiling Cai, Jon Bordner
Publikováno v:
Organic Process Research & Development. 12:447-455
Many years ago anidulafungin 1 was identified as a potentially useful medicine for the treatment of fungal infections. Its chemical and physical properties as a relatively high molecular weight semisynthetic derived from echinocandin B proved to be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a00c5a59a6ae225041509349c94f92ea
https://doi.org/10.1021/op800055h
https://doi.org/10.1021/op800055h
Autor:
Herve Clavier, Ivan Samardjiev, Edwin D. Stevens, Steven P. Nolan, RA Kelly, Jon Bordner, Carl D. Hoff, Luigi Cavallo, Simona Giudice, NM Scott
Publikováno v:
Organometallics. 27:202-210
Complexes of iridium bearing NHC (NHC = N-heterocyclic carbene) ligands were synthesized and fully characterized. The series [(NHC)Ir(cod)Cl] were obtained by simple cleavage of [Ir(cod)Cl]2. The [(NHC)Ir(cod)Cl] complexes were reacted with excess ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f64e09bcb338032394bea900a9182b3b
https://doi.org/10.1021/om701001g
https://doi.org/10.1021/om701001g
Autor:
Nakao Kojima, John W. Wong, Joyce A. Sutcliffe, Jeffrey C. Sims, Debra Decosta, Taisuke Inagaki, Yoon-Jeong Kim, Kiyoshi Tachikawa, Jon Bordner, Koen A. Dekker, Hideo Hirai, Shinichi Sakemi, Nobuji Yoshikawa, Yutaka Sugie, Akemi Sugiura, Truesdell Susan Jane, Yasuhiro Kojima
Publikováno v:
The Journal of Antibiotics. 55:6-18
CJ-15,696 and 7 novel furopyridine antibiotics were isolated from the fungus Cladobotryum varium CL12284. Their structures were determined by X-ray crystallography and spectral analysis. Three biotransformed analogs were also prepared from CJ-15,696.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337399f0f0dd591f112b96b443e01647
https://doi.org/10.7164/antibiotics.55.6
https://doi.org/10.7164/antibiotics.55.6
Autor:
Peter E. Cross, Robert A. Bass, Kemp John Edward Glyn, Roger F. Gammon, Jennifer A. Price, Jon Bordner
Publikováno v:
Tetrahedron: Asymmetry. 12:975-978
Sulfoxidation of the (+)-Noe-lactol derivative of racemic 6,11-dihydrodibenzo[b,e]thiepin-11-ol broke the isosterism and converted an inseparable mixture of two compounds into a separable mixture of four. X-Ray structural determination on one of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d20bdb5480a4b1d21d7a0d226deaf87e
https://doi.org/10.1016/s0957-4166(01)00168-9
https://doi.org/10.1016/s0957-4166(01)00168-9
Publikováno v:
Bioconjugate Chemistry. 12:406-413
Careful attention to technical issues preceded successful crystallography of the ligand-binding domain of estrogen receptor alpha (ERalpha) complexed with CP-336156, a nonsteroidal estrogen agonist/antagonist. An affinity column based on immobilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15809814ce1fa684f805932959fe1a80
https://doi.org/10.1021/bc000127d
https://doi.org/10.1021/bc000127d