Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jon Blunt"'
Autor:
Karen Sutherland, Fangming Kong, Nathan D. Ide, Hahdi H. Perfect, John Draper, Kyle R. Leeman, Mark Olivier, Ke Wang, Jon Blunt, Shengquan Duan, Mark T. Maloney, David Place, Maria M. O’Sullivan, Denis Lynch, Wiglesworth Kristin, Marie McAuliffe
Publikováno v:
Organic Process Research & Development. 20:1191-1202
This is the first in a series of three papers describing commercial manufacturing process development for palbociclib (1). This manuscript focuses on the SNAr coupling between aminopyridine 3 and chloropyrimidine 7. The regioselectivity of the SNAr c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89aa559ae6d8a7d3048240fdafd6876a
https://doi.org/10.1021/acs.oprd.6b00070
https://doi.org/10.1021/acs.oprd.6b00070
Autor:
Maria M. O’Sullivan, Eric M. Cordi, Jon Blunt, Gregory W. Sluggett, Ciaran Byrne, John A. Ragan, Brian G. Conway, Corey L. Stanchina, Sandra Mullane, Esmort Chisowa, Stuart Taylor, Janice E. Sieser, Denis Lynch, Leo Joseph Letendre, Marcella Whelan, Holly Strohmeyer, Robert A. Singer, Paul Bowles, Kyle R. Leeman
Publikováno v:
Organic Process Research & Development. 18:26-35
This is the first in a series of three papers describing the identification and development of a commercial synthesis of filibuvir (1). This contribution describes development of an Evans aldol reaction to control the tertiary alcohol stereocenter, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e980e41e3c1612b4046300761480666
https://doi.org/10.1021/op4002356
https://doi.org/10.1021/op4002356
Autor:
Stuart Taylor, Gregory W. Sluggett, Brian G. Conway, Leo Joseph Letendre, Robert A. Singer, Nicola Mawby, Kevin Meldrum, Jon Blunt, Zhihui Peng, Kyle R. Leeman, John A. Ragan, Holly Strohmeyer, Eric M. Cordi, Li-Jen Ping, Janice E. Sieser, Roberto Colon-Cruz, Brian C. Vanderplas
Publikováno v:
Organic Process Research & Development. 18:36-44
This paper describes an improved sequence for the conversion of an oxazolidinone (3) to a β-keto lactone (5). The primary drivers behind this change were the modest and variable yields observed in the intramolecular cyclization to generate the β-ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::249802ea1a0efa9c951d4e02f1bee3a6
https://doi.org/10.1021/op400236r
https://doi.org/10.1021/op400236r
Autor:
Peter Robert Rose, Denis Lynch, David B. Damon, Darragh Breen, Nga M. Do, Busch Frank R, John A. Ragan, Maria M. O’Sullivan, Eric M. Cordi, Joseph A. Mongillo, Brian C. Vanderplas, Jon Blunt, Ruth E. McDermott, Dennis E. Bourassa, Alanya Engtrakul
Publikováno v:
Organic Process Research & Development. 13:186-197
Development of an efficient bond-forming sequence and optimization of reaction conditions are described for the synthesis of CP-945,598-01 (1·HCl), a CB1 antagonist in clinical studies for the treatment of obesity. Reordering of the bond-forming seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83d0f4ddf324d49a16e57d95f896a5f2
https://doi.org/10.1021/op800255j
https://doi.org/10.1021/op800255j
Autor:
John A. Ragan, Dennis E. Bourassa, Jon Blunt, Darragh Breen, Frank R. Busch, Eric M. Cordi, David B. Damon, Nga Do, Alanya Engtrakul, Denis Lynch, Ruth E. McDermott, Joseph A. Mongillo, Maria M. O’Sullivan, Peter R. Rose, Brian C. Vanderplas
Publikováno v:
Organic Process Research & Development; Mar2009, Vol. 13 Issue 2, p186-197, 12p
Autor:
Benjamin, Robert I.1,2, Blunt, Jon3
Publikováno v:
Sloan Management Review. Summer92, Vol. 33 Issue 4, p7-19. 13p. 1 Diagram.
Autor:
Bertot, John Carlo
Publikováno v:
Government Information Quarterly. 1997, Vol. 14 Issue 3, p236. 19p. 2 Diagrams, 3 Charts.
Publikováno v:
Sloan Management Review. Summer92, Vol. 33 Issue 4, p3-3. 5/6p.
Autor:
Travica, Bob
Publikováno v:
Proceedings of Conference: Organizational Computing Systems; 8/13/1995, p178-188, 11p
Publikováno v:
M@n@gement; 1999, Vol. 2 Issue 3, p233-249, 17p