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Transoral laser microsurgery for oropharyngeal squamous cell carcinoma: A paradigm shift in therapeutic approach

Autor: Jackson, Navdeep S. Upile, Andrew S. Lau, Jon Sheard, Nicholas J. Roland, Terry Jones, Max Robinson, Jeffrey Lancaster, Rebecca Hanlon, Timothy R. Helliwell, David Husband, SP Williams, H. Lewis-Jones, Aditya Shenoy, Sankalap Tandon, J. Rodrigues, Wilkie, F. Bekiroglu, K Beemireddy

Publikováno v: Head & Neck. 38:1263-1270

Background The contemporary treatment of oropharyngeal squamous cell carcinoma (SCC) is an area of debate. We report outcomes of a minimally invasive approach involving transoral laser microsurgery (TLM). Methods A consecutive series of patients (n =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88c4a7827d97c0af13f1a15624918080
https://doi.org/10.1002/hed.24432

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Relative expression of vascular endothelial growth factor isoforms in squamous cell carcinoma of the head and neck

Autor: Maxine S. Emmett, Rowan Oliver Pritchard-Jones, Kathryn A Lightbody, Shilpa Santosh, Jon Sheard, Terence M. Jones, Paul W.A. Goodyear, Steven Lane, Mark D. Wilkie, Mark T. Boyd

Publikováno v: Head & Neck. 38:775-781

BackgroundAlternative splicing of the vascular endothelial growth factor (VEGF) gene results in a family of antiangiogenic isoforms (VEGF(xxx)b), not yet investigated in squamous cell carcinoma of the head and neck (SCCHN). We examined, therefore, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d9679882c6487090f0e837641599197
https://doi.org/10.1002/hed.23959

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IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer

Autor: Max Robinson, Tamara Aleksic, Jon Sheard, Navdeep S. Upile, Hisham Mehanna, Terence M. Jones, Paul W.A. Goodyear, Davy Carlos Rapozo, Ketan A. Shah, Stuart Winter, Valentine M. Macaulay, Cheng Han, Oliver T. Dale

Publikováno v: Carcinogenesis. 36:648-655

Head and neck squamous cell carcinomas (HNSCC) are treated with surgery, radiotherapy and cisplatin-based chemotherapy, but survival from locally-advanced disease remains poor, particularly in patients whose tumors are negative for Human papillomavir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5cb8d53bc1117b491cfc6350be6108a
https://doi.org/10.1093/carcin/bgv053

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Squamous cell carcinoma of the head and neck outside the oropharynx is rarely human papillomavirus related

Autor: Navdeep S. Upile, Max Robinson, Janet M. Risk, Andrew Schache, Phil Sloan, Richard Shaw, Mark T. Boyd, Jon Sheard, Triantafillos Liloglou, Terry Jones, Paul W.A. Goodyear

Publikováno v: The Laryngoscope. 124:2739-2744

Objectives/Hypothesis The incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature. Study Design Case series. Methods Two hundred twenty-one samples were strictly classified to the subsite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc8abe685a66ce1c71a3ef14490fb184
https://doi.org/10.1002/lary.24828

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Publikováno v: Cancer Res
ResearcherID
Cancer research
Schache, A G, Powell, N G, Cuschieri, K S, Leary, S D, Mehanna, H, Rapozo, D, Cubie, H, Junor, E, Monaghan, H, Harrington, K J, Nutting, C M, Schick, U, Lau, A S, Upile, N, Sheard, J, Brougham, K, West, C M L, Oguejiofor, K, Thomas, S, Ness, A R, Pring, M, King, E V, McCance, D, James, J A, Moran, M, Sloan, P, Evans, M & Jones, T M 2016, ' HPV-related oropharyngeal cancer in the United Kingdom : an evolution in understanding of disease etiology ', Cancer Research, vol. 76, no. 22, pp. 6598-6606 . https://doi.org/10.1158/0008-5472.CAN-16-0633
Schache, A G, Powell, N G, Cuschieri, K S, Robinson, M, Leary, S, Mehanna, H, Rapozo, D, Long, A, Cubie, H, Junor, E, Monaghan, H, Harrington, K J, Nutting, C M, Schick, U, Lau, A S, Upile, N, Sheard, J, Brougham, K, West, C M L, Oguejiofor, K, Thomas, S, Ness, A R, Pring, M, Thomas, G J, King, E V, McCance, D J, James, J A, Moran, M, Sloan, P, Shaw, R J, Evans, M & Jones, T M 2016, ' HPV-related oropharynx cancer in the United Kingdom : An evolution in the understanding of disease etiology ', Cancer Research, vol. 76, no. 22, pp. 6598-6606 . https://doi.org/10.1158/0008-5472.CAN-16-0633

A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca48bbe6aa03ccb7e2855b99b9cd298
https://europepmc.org/articles/PMC9158514/

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Squamous cell carcinoma of the head and neck outside the oropharynx is rarely human papillomavirus related

Autor: Navdeep S, Upile, Richard J, Shaw, Terry M, Jones, Paul, Goodyear, Triantafillos, Liloglou, Janet M, Risk, Mark T, Boyd, Jon, Sheard, Phil, Sloan, Max, Robinson, Andrew G, Schache

Publikováno v: The Laryngoscope. 124(12)

The incidence of human papillomavirus (HPV)-driven disease beyond the oropharynx varies greatly in the reported literature.Case series.Two hundred twenty-one samples were strictly classified to the subsites of oral cavity, larynx, or hypopharynx at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abc4e32e7b81503f3b6c55c011fdf3d8
https://pubmed.ncbi.nlm.nih.gov/25042603

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